Controlling the saturation of bound magnetization in variable flip angle (VFA) experiments improves the derived parameter maps. Instead of using special CSMT RF pulses, we kept the rmsB1 constant simply by increasing the RF pulse duration with the square of the flip angle. At 3T, VFA T1 mapping of human brain thus showed better compliance to the Ernst equation than at constant pulse duration or B1

Platelets have recently emerged as important immune modulators in systemic lupus erythematosus (SLE), in addition to their role in thrombosis and cardiovascular disease. However, studies investigating mean platelet volume (MPV) in SLE are often scarce, conflicting and cross-sectional. In this study, MPV was measured in clinical routine throughout a defined time-period to quantify both individual M

Virtual Reality (VR) experiments are used to study human behavior in fire because they allow simulation of fire events with relatively low risks to the participants, while maintaining high levels of experimental control. Manystudies have used VR experiments to explore aspects of the human response to fire threats, but VR experiments as a research method are yet to be subjected to a systematic proc

AbstractBackground: New risk areas for tick-borne encephalitis (TBE) are emerging and the spread of disease and vaccine coverage is unclear in Sweden. We wanted to study the prevalence and levels of TBE-virus (TBEV) antibodies in southern Sweden, and to investigate whether there were individuals with undiagnosed TBE.Materials and Methods: Two cohorts of sera were collected: One group of anonymous

Aims: A diabetic foot ulcer (DFU) is associated with increased cardiovascular risk and mortality, independently of ulcer etiology (ischemic, neuro-ischemic or neuropathic). Ankle–brachial index (ABI) is the most commonly used test when diagnosing peripheral macrovascular disease and is a well-known marker for increased cardiovascular risk. Transcutaneous oxygen pressure (TcPO2) is considered to be

Background: Therapeutic activation of tumor-infiltrating lymphocytes using monoclonal antibodies targeting PD1 or PD-L1 (immune checkpoint inhibitors—ICIs) has revolutionized treatment of specific solid tumors in adult cancer patients, and much hope has been placed on a similar effect in relapsed or refractory solid pediatric tumors. Recent clinical trials have disappointingly shown an almost none

Objectives Most indices of disease activity in SLE combine physicians' assessments and laboratory tests. However, there is also a need to capture patients' perspectives of disease activity. Consequently, we need new, preferably quick and easy instruments to collect this information, which can be very useful for online consultations and registry purposes. We compared patients' assessments of SLE di

Background: Glioblastoma is the most common primary malignant brain tumor in adults. Previous studies have suggested that CRP (C-reactive protein) could serve as a biomarker candidate as well as a prognostic factor in glioblastoma patients, and we here further investigate its potential role. Materials and methods: Publicly available datasets were used to compare gene expression between brain sampl

The problem of finding maximum (or minimum) witnesses of the Boolean product of two Boolean matrices (MW for short) has a number of important applications, in particular the all-pairs lowest common ancestor (LCA) problem in directed acyclic graphs (dags). The best known upper time-bound on the MW problem for n× n Boolean matrices of the form O(n2.575) has not been substantially improved since 2006

Recension av Sam Wineburg, Why Learn History? (When It's Already on Your Phone), University of Chicago Press, 2018

2011 är ett viktigt år för den svenska gymnasieutbildningen. Genom en omfattande gymnasiereform, förkortad GY11, sjösattes den nya gymnasieskolan. Genom GY11 skulle yrkesutbildningarna lägga större betoning på yrkesämnena, ha karaktären av färdigutbildning, avslutas med en yrkesexamen samt bli mer avnämarstyrda och präglade av arbetslivets behov. Förhoppningen var att yrkesutbildningarna skulle bl