Huntington's disease (HD) is a fatal genetic neurodegenerative disorder. It has mainly been considered a movement disorder with cognitive symptoms and these features have been associated with pathology of the striatum and cerebral cortex. Importantly, individuals with the mutant huntingtin gene suffer from a spectrum of non-motor features often decades before the motor disorder manifests. These sy

This study examines the consequences of grade inflation at the upper secondary education level on enrolment in higher education and earnings for Sweden. Although grade inflation is unfair and may imply inefficient allocation of human resources, current knowledge of grade inflation effects on individual outcomes is scarce. One explanation is probably the challenge of measuring and estimating causal

The content of obsessions in obsessive–compulsive disorder (OCD) often run contrary to the actual self of the individual experiencing them. The ego-dystonic nature of obsessions has led some researchers to propose that individuals with OCD form these false beliefs about themselves due to limited introspective access. The current study therefore aimed to extend on recent findings from non-clinical

The lower Cambrian Lagerstätte of Sirius Passet, Peary Land, North Greenland, is one of the oldest of the Phanerozoic exceptionally preserved biotas. The Lagerstätte evidences the escalation of numbers of new body plans and life modes that formed the basis for a modern, functionally tiered ecosystem. The fauna is dominated by predators, infaunal, benthic and pelagic, and the presence of abundant n

The flame dynamics in a novel, ultra-lean non-premixed model gas turbine (GT) burner flame was numerically studied using large eddy simulation (LES) coupled with probability density function (PDF) based on the Euler stochastic field (ESF) method. One non-reacting case and three reacting cases with global equivalence ratio ϕglob=1.0,0.6,0.3 were simulated. Comparison of mean flow fields and OH dist

Background and purpose — Having patients self-evaluate the outcome is an important part of the follow-up after knee arthroplasty. The Forgotten Joint Score-12 (FJS-12) introduced joint awareness as a new approach, suggested to be sensitive enough to differentiate well-functioning patients. This study evaluated the Swedish translation of the FJS-12 and investigated the validity, reliability, and in

Background and Aims: Radionuclide therapy is systemic, targeted radiotherapy. As such, we can apply the basic principles of radiobiology used in everyday practice in radiation oncology, as a means of tailoring the treatment to each patient and optimizing the balance between efficacy and toxicity. The most common type of radionuclide therapy used for the treatment of neuroendocrine tumors, is 177Lu

A gardener in Småland, southeastern Sweden, tells that her father cultivated a double daylily, Hemerocallis fulva, with variegated leaves in Stockholm in the mid 20th century. When she moved to Småland, 45 years ago, she brought a piece of his plant with her, and later on she has spread the plant to others. This daylily, known as "Kwanso Variegata", was first found in Japan in 1776, and since then

Sulfite reductase (SiR) contains in the active site a unique assembly of siroheme and a [4Fe4S] cluster, linked by a cysteine residue. Siroheme is a doubly reduced variant of heme that is not used for a catalytic function in any other enzyme. We have used non-equilibrium Green's function methods coupled with density functional theory computations to explain why SiR employs siroheme rather than hem

The recent global success story of Nordic noir, that encompasses products from film and television as well as literature, is often attributed to the great popularity of its places and characters. Many of the protagonists of some of the most popular TV-shows, for instance, are described as more in depth-characters than many of their European and American counterparts. Notable examples are Kurt Wall

Background: Quinoa is a pseudocereal with relatively high content of proteins and minerals that also contains mineral inhibitors such as phytate. The aim of the present study was to evaluate lactic acid fermentation and dry roasting on the nutritional quality and sensory attributes of quinoa. Various processes were evaluated, and quinoa grains were dry-roasted, milled, and fermented, either with o

This paper aims to describe the reasons why abnormal heat transfer occurs under the condition of regenerative cooling applied in scramjet engines. Supercritical n-decane flowing in a horizontal tube under various mass flow rates (G = 0.001, 0.002, 0.003, 0.004 kg/s) and heat fluxes (qw = 100, 200, 300, 400 kW/m2) is investigated by numerical simulations. The mechanisms of the abnormal heat transfe

PURPOSE: This study explored nursing experiences using interpreters in primary healthcare settings. METHODS: Eight nurses in southern Sweden were subjected to semistructured interviews. The responses were divided into three categories using content analysis: interpreter influence, challenges, and strategies. RESULTS: Despite using an interpreter to minimize language barriers, nurses do not achieve

The 1st International Hip-related Pain Research Network meeting discussed four prioritised themes concerning hip-related pain in young to middle-aged adults: (1) diagnosis and classification of hip-related pain; (2) patient-reported outcome measures for hip-related pain; (3) measurement of physical capacity for hip-related pain; (4) physiotherapist-led treatment for hip-related pain. Thirty-eight

Cardiac thromboembolism attributed to atrial fibrillation (AF) is responsible for up to one-third of ischemic strokes. Stroke may be the first manifestation of previously undetected AF. Given the efficacy of oral anticoagulants in preventing AF-related ischemic strokes, strategies of searching for AF after a stroke using ECG monitoring followed by oral anticoagulation (OAC) treatment have been pro

Electrochemical synthesis of ammonia through the nitrogen reduction reaction (NRR) has the possibility to revolutionize our production of ammonia and to save our planet from both emissions and large energy consumption. In this study, a perovskite structured lanthanum chromite catalyst (LaCrO3) is synthesized, characterized as well as electrochemically evaluated for NRR. The highest ammonia yield i

Thermosensitive transient receptor potential (TRP) ion channels detect changes in ambient temperature to regulate body temperature and temperature-dependent cellular activity. Rodent orthologs of TRP vanilloid 2 (TRPV2) are activated by nonphysiological heat exceeding 50 °C, and human TRPV2 is heat-insensitive. TRPV2 is required for phagocytic activity of macrophages which are rarely exposed to ex

Thermodynamic uncertainty relations quantify how the signal-to-noise ratio of a given observable is constrained by dissipation. Fluctuation relations generalize the second law of thermodynamics to stochastic processes. We show that any fluctuation relation directly implies a thermodynamic uncertainty relation, considerably increasing their range of applicability. In particular, we extend thermodyn

Use of image-guided radiation therapy (IGRT) helps to account for daily prostate position changes during radiation therapy for prostate cancer. However, guidelines for the use of IGRT are scarce. An ESTRO panel consisting of leading radiation oncologists and medical physicists was assembled to review the literature and formulate a consensus guideline of methods and procedure for IGRT in prostate c