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Background: Drug repurposing provides a cost-effective approach to address the need for breast cancer prevention and therapeutics. We aimed to identify actionable druggable targets using Mendelian randomization (MR) and then validate the candidate drugs using population-based analyses. Methods: We identified genetic instruments for 1406 actionable targets of approved non-oncological drugs based on

Despite improvements in cancer survival, cancer therapy–related cardiovascular toxicity has risen to become a prominent clinical challenge. This has led to the growth of the burgeoning field of cardio-oncology, which aims to advance the cardiovascular health of cancer patients and survivors, through actionable and translatable science. In these Global Cardio-Oncology Symposium 2023 scientific symp

I Sverige överlever idag uppemot 80% av de barnen som är födda extremt för tidigt (födda innan graviditetsvecka 28). Dock medföljer en hög sjuklighet, där uppemot 20% av barnen utvecklar olika sjukdomstillstånd såsom blödning i hjärnas hålrum, även kallat intra-ventrikulär hjärnblödning (IVH). Dessutom löper de extremt för tidigt födda barnen en ökad risk att utveckla en intellektuell och neurologExtremely preterm infants (i.e., born below 28 gestational weeks), are at high risk of developing brain morbidities including intraventricular hemorrhage (IVH) and neurodevelopmental impairment. Despite over 50 years of research, there is currently no effective therapy available for preventing IVH. Insulin-like growth factor 1 (IGF-1) plays a pivotal role in perinatal development. Extremely preter

Starting from the assumption that grammaticalization is rooted in situated language use, the present study tests the connection between functional reanalysis and formal reduction with a synchronic approach. It investigates a case of potential (but not actuated) grammaticalization in Present-Day English, the use of epistemic phrases of the type it could/might be (that), which can serve an adverbial

In grammaticalization, functional reanalysis and formal reduction are often regarded as elements of a unified diachronic process, though rooted in general communicative and cognitive preferences. The present study tests these claims in synchronic language use by investigating potential cases of grammaticalization. Epistemic phrases of the type (it) could/might be (that) in English are potential ca

The 8B+64Zn reaction at 38.5 MeV has been studied at HIE-ISOLDE CERN to investigate proton halo effect on the reaction dynamics. For the first time it was used the only existing post-accelerated 8B beam. The measured elastic scattering angular distribution showed a small suppression of the Coulomb-nuclear interference peak, opposite to what observed for the one-neutron halo nucleus 11Be on the sam

There is ample psycholinguistic evidence that speakers behave efficiently, using shorter and less effortful constructions when the meaning is more predictable, and longer and more effortful ones when it is less predictable. However, the Principle of No Synonymy requires that all formally distinct variants should also be functionally different. The question is how much two related constructions sho

Fell, from the Prescription Medicines Code of Practice Authority (PMCPA), the self-regulatory body of the Association of the British Pharmaceutical Industry (ABPI), agrees with our overarching point that healthcare professionals and organisations have an important role in responding to any formal sanctions that are applied by the PMCPA and ABPI.12 For healthcare professionals and organisations to

Pretend play is usually defined as an activity wherein objects and actions (but also 7 affective expression, at times) are separated from their original meanings. Its developmental 8 appearance is set around the second year of life, and increases dramatically in duration, 9 frequency and quality when play episodes start becoming more complex, both linguistically 10 and interactionally reaching its

Inom beräkningskemi arbetar man mer med molekyler än atomer, studerar stökiometriska relationer, kinetik och geometri, interatomära eletronövergångar medan beräkningsfysik studerar mer atomer och dess kärnor, fasta tillståndet och intraatomära övergångar, oftast närmast mot atomens kärna. Interaktionerna sker på en storleksskala på nanometer eller mindre med energiövergångar som är diskontinuerligThis study presents an approach for partitioned fluid-structure interaction (FSI) applied to large structural deformations, where an incompressible turbulent solver is combined with a structural solver. The implementation is based upon two different open-source libraries by using MPI as a parallel communication protocol, the packages deal.II and OpenFOAM. FSI is achieved through a strongly-coupled

Metal halide perovskites (MHPs) have garnered significant interest as promising candidates for nanoscale optoelectronic applications due to their excellent optical properties. Axially heterostructured CsPbBr3-CsPb(Br(1-x)Clx)3 nanowires can be produced by localized anion exchange of pregrown CsPbBr3 nanowires. However, characterizing such heterostructures with sufficient strain and real space reso

Plantation forests (PF) and natural secondary forests (NSF) are the primary reforestation approaches. The establishment of PF can affect forest hydrological processes by changing soil structure. To date, few studies have focused on these changes and the effects on hydrological processes for the paleo-periglacial landform. To reveal reforestation approaches effects on water infiltration, including

Flooding is a natural but unavoidable disaster that occurs over time. Flooding threatens human life, property, and resources and affects regional and national economies. Through frequency ratio and MaxEnt modeling, flood sensitivity was determined in the Amu Darya River Basin in Badakhshan Province, Afghanistan. Slope, plan curvature, distance to river, rainfall, aspect, land use, elevation, Norma

Charles Tilly was instrumental in launching the comparative study of contentious politics through key contributions delineating and defining the subject matter. But his input is epistemological as well as theoretical and substantive. What characterizes his epistemology is a realist mechanistic explanation rendering mechanisms tools of both explanation and comparison. Employing the realist perspect

Models based on the Ornstein-Uhlenbeck process have become standard for the comparative study of adaptation. Cooper et al. (2016) have cast doubt on this practice by claiming statistical problems with fitting Ornstein-Uhlenbeck models to comparative data. Specifically, they claim that statistical tests of Brownian motion may have too high Type I error rates and that such error rates are exacerbate

Learning semantic-rich representations from raw unlabeled time series data is critical for downstream tasks such as classification and forecasting. Contrastive learning has recently shown its promising representation learning capability in the absence of expert annotations. However, existing contrastive approaches generally treat each instance independently, which leads to false negative pairs tha