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Third world list of cetrarioid lichens: A databased tool for documentation of nomenclatural data - lessons learned
The third version of the world list of cetrarioid lichens contains 572 names representing 149 accepted species. It is presented in a new, electronical form, based on a FileMaker-powered database, allowing users to view data in different sets and to perform searches. Type information is added for most of the names, and new information regarding the phylogenetic status of accepted taxa is introduced
Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases
Class II ribonucleotide reductases (RNR) catalyze the formation of an essential thiyl radical by homolytic cleavage of the Co-C bond in their adenosylcobalamin (AdoCbl) cofactor. Several mechanisms for the dramatic acceleration of Co-C bond cleavage in AdoCbl-dependent enzymes have been advanced, but no consensus yet exists. We present the structure of the class II RNR from Thermo toga maritima in
Environmental exposure to POPs and heavy metals in urban children from Dhaka, Bangladesh
Persistent organic pollutants (POPs) and heavy metals are well known environmental pollutants. Even though numerous studies have been carried out to assess human exposures to these compounds, there is still a lack of data on humans from developing countries, especially in underprivileged children. The objective of this study was to assess the exposure to POPs and heavy metals in children from Dhak
How Humans Have Shaped European Nature
Women pioneers in basal ganglia surgery
Background: Stereotactic functional neurosurgery on basal ganglia has a long history and the pioneers are mostly men. We aimed at finding out if there were women who have contributed pioneering work in this field. Methods: The literature was searched to identify women who have been first to publish innovative papers related to human basal ganglia surgery. Results: Six women fulfilling our criteria
Twilight ascents by common swifts, Apus apus, at dawn and dusk: acquisition of orientation cues?
Common swifts are specialist flyers spending most of their life aloft, including night-time periods when this species roosts on the wing. Nocturnal roosting is preceded by a vertical ascent in twilight conditions towards altitudes of up to 2.5 km, behaviour previously explained as flight altitude selection for sleeping. We examined the nocturnal flight behaviour of swifts, as uniquely identified b
beta-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia
Mice deficient in the zinc-sensor GPR39, which has been demonstrated to protect cells against endoplasmatic stress and cell death in vitro, display moderate glucose intolerance and impaired glucose-induced insulin secretion. Here, we use the Tet-On system under the control of the proinsulin promoter to selectively overexpress GPR39 in the beta cells in a double transgenic mouse strain and challeng
2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: a randomised, multicentre trial
Background Optimum surgical resection margins for patients with clinical stage IIA-C cutaneous melanoma thicker than 2 mm are controversial. The aim of the study was to test whether survival was different for a wide local excision margin of 2 cm compared with a 4-cm excision margin. Methods We undertook a randomised controlled trial in nine European centres. Patients with cutaneous melanoma thicke
Functional Mannose-Binding Lectin Haplotype Variants are Associated with Alzheimer's Disease
Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimer's disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymo
Model based iterative reconstruction IMR gives possibility to evaluate thinner slice thicknesses than conventional iterative reconstruction iDose(4) - a phantom study
Computed tomography (CT) is one of the most important modalities in a radiological department, which produces images with high diagnostic confidence, but in some cases contributes to a high radiation dose to the patient. The radiation dose can be reduced by the use of advanced image reconstruction algorithms. This study was done on a Philips Brilliance iCT with iterative reconstruction iDose(4) an
A randomized DBPC trial to determine the optimal effective and safe dose of a SLIT-birch pollen extract for the treatment of allergic rhinitis: results of a phase II study.
Sublingual Immunotherapy (SLIT) is a potential efficacious and safe treatment option for patients with respiratory, IgE-mediated allergic diseases. A combined tolerability, dose finding study with a sublingual liquid birch pollen preparation (SB) was conducted.
What is wrong with the world?
Independent Fine-Tuning of the Intrawall Porosity and Primary Mesoporosity of SBA-15
We present a study in which the intrawall porosity and primary mesoporosity. of SBA-15 are independently controlled by modifying the strength of the molecular interaction that governs the formation of the material. The interactions are targeted at specific times during the process of formation, which results in selective tuning of the porosity, while other characteristics of the SBA-15 material ar
Recombinant activated factor VII: 30 years of research and innovation.
Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital haemophilia and inhibitors. The story of its development began in the 1970s, when FVIIa was identified as one of the activated coagulation factors that has minimal potential for inducing thromboembolic side-effects. Extensive research over the last 30 years has greatly increased
Reliability of beams according to Eurocodes in serviceability limit state
To achieve a relatively consistent probability of failure for structural elements, most design codes apply reliability based code calibration process. Such approaches commonly focus on the strength of the structural members, which is related to the ultimate limit state (ULS). However in the design of beams the performance of the structural elements is often limited by the serviceability requiremen
Copper doped TiO2 nanoparticles characterized by X-ray absorption spectroscopy, total scattering, and powder diffraction - a benchmark structure-property study
Metal functionalized nanoparticles potentially have improved properties e. g. in catalytic applications, but their precise structures are often very challenging to determine. Here we report a structural benchmark study based on tetragonal anatase TiO2 nanoparticles containing 0-2 wt% copper. The particles were synthesized by continuous flow synthesis under supercritical water-isopropanol condition
Balancing Life with an Increased Risk of Cancer: Lived Experiences in Healthy Individuals with Lynch Syndrome
Possibilities to undergo predictive genetic testing for cancer have expanded, which implies that an increasing number of healthy individuals will learn about cancer predisposition. Knowledge about how an increased risk of disease influences life in a long-term perspective is largely unknown, which led us to explore lived experiences in healthy mutation carriers with Lynch syndrome. Individual inte
Target Temperature Management after Out-of-Hospital Cardiac Arrest, an International, Multi-Centre, Randomised, Parallel Groups, Assessor Blinded Clinical Trial-Rationale and Design of the Ttm-Trial
Swedish clinical guidelines-Prevention and management of metabolic risk in patients with severe psychiatric disorders
Individuals with severe psychiatric disorders are more likely than the population at large to develop metabolic derangements such as overweight and diabetes. Cardiovascular disease is also more frequently seen in this group. Contributing factors may include inappropriate diet or lack of physical activity, but antipsychotic medication may also play a role. Seven Swedish specialist medical societies