Messenger molecules and receptors in the human trigeminovascular system
The initiation of a migraine attack involves a primary central nervous system dysfunction with subsequent activation of the trigeminovascular system. In trigeminal ganglia, the expression of calcitonin gene-related peptide (CGRP), substance P (SP) and nitric oxide synthase (NOS) have been demonstrated by immunocytochemistry. During migraine attacks, the level of released CGRP is increased. Meanwhi
