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Rationale: Atrial fibrillation causes one-fifth of ischemic strokes, with a high risk of early recurrence. Although long-term anticoagulation is highly effective for stroke prevention in atrial fibrillation, initiation after stroke is usually delayed by concerns over intracranial hemorrhage risk. Direct oral anticoagulants offer a significantly lower risk of intracranial hemorrhage than other anti

Objective: To summarize the published evidence in the literature on the role of ultrasound and elastography to assess skin involvement in systemic sclerosis (SSc). Methods: A systematic literature review (SLR) was performed within the “Skin Ultrasound Working Group” of the World Scleroderma Foundation, according to the Cochrane Handbook. A search was conducted in Pubmed, Cochrane Library and Embas

Objectives: This study aims to investigate the inter-rater reliability and agreement of the diagnosis of otitis media with effusion, acute otitis media, and no effusion cases based on an otoscopy image and in some cases an additional wideband tympanometry measurement of the patient. Methods: 1409 cases were examined and diagnosed by an otolaryngologist in the clinic, and otoscopy examination and w

Objective: Basal ganglia structures play an important role in the pathophysiology of absence epilepsy, known as remote control of absence seizures. We examined the role of the nigrostriatal dopaminergic pathway in absence epilepsy through behavioral and electroencephalography (EEG) parameters, immunohistochemical, and biochemical characteristics of dopamine and serotonin in the genetic absence epi

The Commentator is a small-scale computer implementation of a model oftext production. The system simulates human behavior from the perceptionof events on a screen to the utterances. It is designed to allow anyone havingsome knowledge of Basic and access to a microcomputer to study the semantics of words (e.g. localization and movement predicates such asapproach, left/right, near, in front of, turThe Commentator is a small-scale computer implementation of a model oftext production. The system simulates human behavior from the perceptionof events on a screen to the utterances. It is designed to allow anyone havingsome knowledge of Basic and access to a microcomputer to study the semantics of words (e.g. localization and movement predicates such asapproach, left/right, near, in front of, tur

Climate change is an existential threat to human survival, the social organization of society, and the stability of ecosystems. It is thereby profoundly frightening. In the face of threat, people often want to protect themselves instead of engaging in mitigating behaviors. When psychological resources are insufficient to cope, people often respond with different forms of denial. In this dissertati

Environmental changes such as extreme weather events become increasingly noticeable worldwide. Earth observation data provide information about such changes, but little is known about citizens’ perceptions of and responses to such changes. Across three studies, we assess whether people’s place attachment on different regional levels predicts interest in earth observation data, and whether perceive

While the virus SARS-CoV-2 spreads all over the world, most countries have taken severe measures to protect their citizens and slow down the further spread of the disease COVID-19. These measures affect individuals, communities, cities, countries, and the entire planet. In this paper, we propose that the tremendous consequences of the corona crisis invite environmental psychology to focus more str

This article explains how the USSR's State Security Committee (KGB) inadvertently spurred the rise of a dissident movement in the Soviet Union. Under the leadership of Vladimir Semichastnyi in 1962 and 1963, the KGB launched a new offensive against “ideological subversion,” aimed primarily at Soviet intellectuals who were skeptical but not hostile in their views of Soviet Communism. These intellec

BACKGROUND: Breast-conserving surgery followed by radiotherapy is part of standard treatment for early-stage breast cancer. Hypoxia is common in cancer and may affect the benefit of radiotherapy. Cells adapt to hypoxic stress largely via the transcriptional activity of hypoxia-inducible factor (HIF)-1α. Here, we aim to determine whether tumour HIF-1α-positivity and hypoxic gene-expression signatur

Lymphocytes from various lymphoid organs of WF and BN rats were isolated and stained for acid alpha-naphthyl acetate esterase (ANAE) activity. From all organs examined-peripheral blood, lymph nodes, and spleen-70-80% of the lymphocytes were stained for ANAE activity. After separation into B and non-B cells by affinity chromatography on anti-Ig columns, esterase-negative lymphocytes were detected i