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The Lund Stem Cell Center at Lund University has relaunched its Professional Development Program (PDP), which provides PhD students support beyond research, equipping them with the personal and professional skills essential for long-term career success. While most doctoral programs focus on scientific expertise, the PDP broadens that approach by equipping students with skills for career growth, se
Jenny Hansson, associate professor at Lund University, has been awarded an 11 million SEK grant from the Swedish Society for Medical Research (SSMF). This five-year SSMF Consolidator Grant will support her research into acute leukemia, focusing on uncovering the biological differences between childhood and adult forms of the disease. Why does childhood leukemia behave so differently from adult leu
https://www.stemcellcenter.lu.se/article/jenny-hansson-awarded-11-million-sek-swedish-society-medical-research - 2025-12-25
After 20 years of research on gene therapy and the rare blood disease, Diamond–Blackfan Anemia, DBA, researcher Johan Flygare had reached a point where he and his colleagues had done everything they could in the lab. Even though they had proof of concept their gene therapy would work, engaging companies had been difficult. Then, in 2021, he received an e-mail. The message came from American entrep
https://www.stemcellcenter.lu.se/article/science-start-developing-gene-therapy-rare-blood-disorder - 2025-12-25
Outside the different examining rooms at paediatric oncology unit 64 hang laminated name signs with rainbows, unicorns and tractors that the young patients have made themselves. Each year, the unit receives around 60 new paediatric cancer patients from southern Sweden requiring examination or treatment. Of these, 85 per cent survive. Kees-Jan Pronk shares his time between being a doctor in paediat
https://www.stemcellcenter.lu.se/article/all-energies-fighting-pediatric-cancer - 2025-12-25
Researcher Emma Hammarlund realized that geological measurement methods can also be used for medical purposes. With a simple hair sample, she hopes to find cancer at an early stage. First in the study are prostate cancer and breast cancer. Now her project has been selected for the Royal Swedish Academy of Engineering Sciences' (IVA) 100 list. The list also includes eight other research projects fr
https://www.stemcellcenter.lu.se/article/ivas-100-list-hair-analysis-find-cancer-early-stage - 2025-12-25
By presenting cancer research as a battle between good and evil – and himself as a hacker attacking cells to make them kind, PhD student Luís Oliveira took home the win in the Researchers' Grand Prix. His win is the fifth in a row for Lund University and the second in a row for Lund Stem Cell Center - in the competition where researchers from all over the country challenge each other in presentati
https://www.stemcellcenter.lu.se/article/win-fifth-time-row-luis-oliveira-wins-researchers-grand-prix - 2025-12-25
A team of international researchers led by Professor Johan Jakobsson at Lund University has secured a 52 million SEK grant from the Aligning Science Across Parkinson’s (ASAP) initiative, in partnership with the Michael J Fox Foundation to investigate how mobile genetic elements —commonly referred to as "jumping genes"—contribute to neuroinflammation and the progression of Parkinson’s disease. Jump
https://www.stemcellcenter.lu.se/article/52-million-sek-goes-uncovering-genetic-drivers-parkinsons-disease - 2025-12-25
– I have red cells in my dish! When the phone call from PhD student Fábio Rosa came through, Professor Filipe Pereira knew that this was the start of something big. All their work had been leading to this moment. The red cells in the dish were from a mouse, and Filipe and his colleagues had been trying to reprogramme them into dendritic cells, specfically type 1 conventional dendritic cells, (cDC1
https://www.stemcellcenter.lu.se/article/tracing-academic-startups-journey-lab-discovery-cancer-therapy - 2025-12-25
Registries are one way to provide longitudinal, observational data, giving rise to a range of possibilities in terms of audit and research. They allow examining approaches to management, which would not be feasible by a trial or where there was no trial data (currently or likely ever) available. In this Perspective, we will discuss aspects of their design, analysis, and use in the field of pain. R
https://www.lupop.lu.se/article/perspectives-pain-registries - 2025-12-25
Epidemiologists commonly use an adjusted hazard ratio or incidence density ratio, or a standardized mortality ratio, to measure a difference in all-cause mortality rates. They seldom translate it into an age-, time-, or probability-based measure that would be easier to communicate and to relate to. Several articles have shown how to translate from a standardized mortality ratio or hazard ratio to
Results of randomized trials and observational studies can be difficult to communicate. Results are often presented as risk or survival functions stratified by the treatment or exposure (1, 2). However, a contrast between the stratified risk functions is often of primary interest. Here we propose a “twister” plot to visualize contrasts in risk over the duration of a study. The twister plot is a −9
https://www.lupop.lu.se/article/twister-plots-time-event-studies - 2025-12-25
Psychosocial constructs can only be assessed indirectly, and measures are typically formed by a combination of indicators that are thought to relate to the construct. Reflective and formative measurement models offer different conceptualizations of the relation between the indicators and what is sometimes conceived of as a univariate latent variable supposed to correspond in some way to the constr
Mendelian randomization (MR) is often used to estimate effects of time-varying exposures on health outcomes using observational data. However, MR studies typically use a single measurement of exposure and apply conventional instrumental variable (IV) methods designed to handle time-fixed exposures. As such, MR effect estimates for time-varying exposures are often biased, and interpretations are un
https://www.lupop.lu.se/article/mendelian-randomization-repeated-measures-time-varying-exposure - 2025-12-25
Lifetime risk measures the cumulative risk for developing a disease over one’s lifespan. Modeling the lifetime risk must account for left truncation, the competing risk of death, and inference at a fixed age. In addition, statistical methods to predict the lifetime risk should account for covariate-outcome associations that change with age. In this paper, we review and compare statistical methods
https://www.lupop.lu.se/article/comparison-statistical-methods-predict-residual-lifetime-risk - 2025-12-25
The Diet, Cancer and Health—Next Generations (DCH-NG) study is a large population-based cohort study that was established as a resource for transgenerational research. The cohort is an extension of the Diet, Cancer and Health (DCH) cohort. The aim of this paper was to describe the study design and methods and to investigate the representativeness of participants by comparing participants with non-
Karin Larsson's presentation from the GIS seminar is now available Read more here.
https://www.lupop.lu.se/article/what-gis-and-what-can-it-be-used - 2025-12-25
Recruiting participants to a clinical study is a resource-intensive process with a high failure rate. The Scottish Health Research Register (SHARE) provides recruitment support service which helps researchers recruit participants by searching patients’ Electronic Health Records (EHRs). The current study aims to evaluate the performance of SHARE in participant recruitment. Read the paper at https:/
Modern artificial intelligence techniques have solved some previously intractable problems and produced impressive results in selected medical domains. One of their drawbacks is that they often need very large amounts of data. Pre-existing datasets in the form of national cancer registries, image/genetic depositories and clinical datasets already exist and have been used for research. In theory, t
https://www.lupop.lu.se/article/registries-databases-and-repositories-developing-artificial-intelligence-cancer-care - 2025-12-25
Background: The Danish National Patient Registry is a major resource for Danish epidemiology. Only a few studies have been conducted to check the validity of the reporting of systemic anticancer treatments. In this study, we assessed this validity for a range of cancer types over a long period of time. Patients and Methods: We extracted systemic anticancer treatment procedures from the Danish Nati
The DMSKW is a valuable structure in providing safety data on drug exposure during pregnancy and lactation in combination with information on disease activity up to 6 years postpartum. This article will be the reference for describing the methods of future publications from the DMSKW. Read the paper at https://journals.sagepub.com/doi/10.1177/17562864211054956
