Published 27 September 2020 Alterations in the human metabolome occur years before clinical manifestation of type 2 diabetes (T2DM). By contrast, there is little knowledge of how metabolite alterations in individuals with diabetes relate to risk of diabetes complications and premature mortality. Metabolite profiling was performed using liquid chromatography-mass spectrometry in 743 participants wi

https://www.lupop.lu.se/article/plasma-metabolites-associate-all-cause-mortality-individuals-type-2-diabetes - 2025-03-13

Published 28 September 2020 Dementia disorders predispose for lethal complications and decrease life expectancy. A more profound knowledge regarding end‐stage conditions in dementia could therefore ameliorate treatment and care of these patients. Read more at https://onlinelibrary.wiley.com/doi/full/10.1111/ene.14450

https://www.lupop.lu.se/article/cause-death-autopsy-confirmed-dementia-disorders - 2025-03-13

Published 28 September 2020 The Danish National Patient Registry (DNPR) has been the source of several epidemiological studies of inflammatory bowel disease (IBD). However, the validation dates back to 1996 and lacks outpatient records and disease classification. The aim of this study was to update the validation and assess the validity and reliability of using the registry in disease classificati

https://www.lupop.lu.se/article/validation-ulcerative-colitis-and-crohns-disease-and-their-phenotypes-danish-national-patient - 2025-03-13

Published 29 September 2020 The aim was to investigate associations between the experience of parental separation/divorce in childhood and tobacco smoking in adulthood, adjusting for economic stress in childhood and adulthood and psychological health (General Health Questionnaire GHQ12). Methods: The 2012 public-health survey in Skåne, southern Sweden, is a cross-sectional postal questionnaire pop

https://www.lupop.lu.se/article/parental-separationdivorce-childhood-and-tobacco-smoking-adulthood-population-based-study - 2025-03-13

Published 29 September 2020 To compare consultations carried out via video with those performed in person for patients with painful, hard-to-heal ulcers, with a focus on ulcer pain and pain treatment. A further aim was to investigate predictors for pain and pain treatment. Read more at https://www.magonlinelibrary.com/doi/full/10.12968/jowc.2020.29.Sup8.S18

https://www.lupop.lu.se/article/pain-and-analgaesics-patients-hard-heal-ulcers-using-telemedicine-or-standard-consultations - 2025-03-13

Published 30 September 2020 Statins, commonly used to treat hypercholesterolemia, have also been proposed as anti-cancer agents. The identification of a predictive marker is essential. The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), which is inhibited by statins, might serve as such a marker. Thorough antibody validation was performed for four different HMGCR antibodies. Tumor express

https://www.lupop.lu.se/article/statin-use-hmgcr-expression-and-breast-cancer-survival-malmo-diet-and-cancer-study - 2025-03-13

Published 30 September 2020 With the increased number of cancer survivors, it is necessary to explore the effect of cancer and its treatments on pregnancy outcomes, such as preterm birth, which seriously endangers the health of offspring. We aimed to explore the risk of being born preterm among offspring of cancer survivors. Read more at https://www.frontiersin.org/articles/10.3389/fonc.2020.01352

https://www.lupop.lu.se/article/risk-being-born-preterm-offspring-cancer-survivors-national-cohort-study - 2025-03-13

Published 1 October 2020 The Swedish National Quality Registries (NQRs) contain individual-level health care data for specific patient populations, or patients receiving specific interventions. Approximately 90% of the 105 Swedish NQRs include any patient-reported outcome measure, with EQ-5D being the most common. As there has been no general overview of EQ-5D data within the NQRs, this study fill

https://www.lupop.lu.se/article/collection-and-use-eq-5d-follow-decision-making-and-quality-improvement-health-care-case-swedish - 2025-03-13

Published 1 October 2020 To determine development of new and worsening meniscal damage over 5 years after acute anterior cruciate ligament (ACL) injury comparing rehabilitation plus early ACL reconstruction (’earlyACLR’) versus rehabilitation with optional delayed ACL reconstruction (’optional-delayed-ACLR’). Read more at https://bjsm.bmj.com/content/bjsports/early/2019/10/25/bjsports-2019-101125.

https://www.lupop.lu.se/article/does-early-anterior-cruciate-ligament-reconstruction-prevent-development-meniscal-damage-results - 2025-03-13

Published 2 October 2020 Housing adaptation aims to enable clients to live independently in their own homes. Studies focusing on participation in everyday life following a housing adaptation are lacking and needed. This study aimed to explore housing adaptation clients' experiences of participation in everyday life before and after a housing adaptation, through the lens of a housing adaptation, us

https://www.lupop.lu.se/article/participation-everyday-life-and-after-housing-adaptation - 2025-03-13

Published 2 October 2020 This study explored factors associated with interest in taking PrEP among men who have sex with men (MSM) attending HIV testing venues in Sweden. Data from 658 HIV-negative respondents, surveyed by a questionnaire at six sites, were analyzed descriptively and by univariable and multivariable logistic regression. Read more at https://link.springer.com/article/10.1007/s10508

https://www.lupop.lu.se/article/interest-taking-hiv-pre-exposure-prophylaxis-associated-behavioral-risk-indicators-and-self - 2025-03-13

Published 3 October 2020 Health impact assessments of differential air pollution rely on epidemiologically established relationships between concentration levels where people are exposed and adverse health outcomes. To assess air pollution concentrations, land use regression is commonly used. However, an alternative tool is dispersion modelling, where a detailed inventory of pollution sources toge

https://www.lupop.lu.se/article/particle-concentrations-dispersion-modelling-and-evaluation-southern-sweden - 2025-03-13

Published 2 October 2020 While the relationship between hypertension and incident intracerebral haemorrhage is well established, other risk factors are less clear. This study examined risk factors for primary intracerebral haemorrhage, separately for lobar and non-lobar intracerebral haemorrhage. Read more at https://journals.sagepub.com/doi/full/10.1177/2396987320932069

https://www.lupop.lu.se/article/risk-factors-intracerebral-haemorrhage-results-prospective-population-based-study - 2025-03-13

Published 3 October 2020 It is discussed whether fetal scalp stimulation (FSS) test is a reliable complimentary tool to cardiotocography (CTG) to assess fetal wellbeing during labor. The test is based on the assumption that a well-oxygenated fetus, in contrast to the depressed fetus, will respond to a certain stimulus. The aim of this study was to investigate the effectiveness of the FSS-test. Rea

https://www.lupop.lu.se/article/effectiveness-fetal-scalp-stimulation-test-assessing-fetal-wellbeing-during-labor-retrospective - 2025-03-13

Published 3 October 2020 Reports on perioperative complications after postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for nonseminoma germ cell tumour (NSGCT) are from experienced single centres, with a lack of population-based studies. Read more at https://pubmed.ncbi.nlm.nih.gov/31506250/

https://www.lupop.lu.se/article/surgical-complications-postchemotherapy-retroperitoneal-lymph-node-dissection-nonseminoma-germ-cell - 2025-03-13

Published 5 October 2020 The EOSC-Nordic project aims to facilitate the coordination of EOSC relevant initiatives within the Nordic and Baltic countries and exploit synergies to achieve greater harmonisation at policy and service provisioning across these countries, in compliance with EOSC agreed standards and practices. The project brings together a strong consortium of 24 complementary partners

https://www.lupop.lu.se/article/d41-assessment-fair-uptake-among-regional-digital-repositories - 2025-03-13

Published 5 October 2020 The use of primary care electronic health records for research is abundant. The benefits gained from utilising such records lies in their size, longitudinal data collection and data quality. However, the use of such data to undertake high quality epidemiological studies, can lead to significant challenges particularly in dealing with misclassification, variation in coding

https://www.lupop.lu.se/article/data-extraction-epidemiological-research-dexter-novel-tool-automated-clinical-epidemiology-studies - 2025-03-13

Published 6 October 2020 Medical Education research suffers from several methodological limitations including too many single institution, small sample-sized studies, limited access to quality data, and insufficient institutional support. Increasing calls for medical education outcome data and quality improvement research have highlighted a critical need for uniformly clean and easily accessible d

https://www.lupop.lu.se/article/development-and-maintenance-medical-education-research-registry - 2025-03-13

Published 6 October 2020 In the Asian region, no international organ transplantation registry exists. Individual centers maintain their own database, or some countries developed a national registration system. To promote collaboration among Asian transplantation societies, the Asian Society of Transplantation (AST) has developed an international transplantation registry for the Asian countries tha

https://www.lupop.lu.se/article/development-asian-transplant-registry-under-asian-society-transplantation - 2025-03-13

Published 7 October 2020 Clinical trials are the standard approach for evaluating new treatments, but may lack the power to assess rare outcomes. Trial results are also necessarily restricted to the population considered in the study. The availability of routinely collected healthcare data provides a source of information on the performance of treatments beyond that offered by clinical trials, but

https://www.lupop.lu.se/article/bayesian-hierarchical-approach-multiple-outcomes-routinely-collected-healthcare-data - 2025-03-13