Published 16 September 2020 Adult-onset growth hormone deficiency (AGHD) is usually the last deficiency to be substituted in hypopituitarism. In children with documented GH deficiency, treatment without delay is crucial for achieving optimal effects on growth and development. In adults, it is not known whether a delay in treatment initiation influences biochemical response and the favourable physi

https://www.lupop.lu.se/article/early-versus-late-initiation-gh-replacement-adult-onset-hypopituitarism - 2025-07-05

Published 16 September 2020 Rates of knee replacement (KR) are increasing worldwide. Based on population and practice changes, there are forecasts of a further exponential increase in primary knee replacement through to 2030, and a corresponding increase in revision knee replacement. We used registry data to document changes in KR over the past 15 years, comparing practice changes across Sweden, A

https://www.lupop.lu.se/article/increases-rates-primary-and-revision-knee-replacement-are-reducing-15-year-registry-study-across-3 - 2025-07-05

Published 10 March 2018 In the annual open call Formas welcomes applications within its three areas of responsibility - Environment, Agricultural Sciences and Spatial Planning. The purpose of the call is to enable researchers to address self-identified research needs and is divided into three sub-calls:Research and development projectsResearch and development projects for future research leadersMo

https://www.lupop.lu.se/article/formas-annual-open-call-2018-now-open - 2025-07-05

Published 17 September 2020 Influenza may precipitate cardiovascular disease, but influenza typically peaks in winter, coinciding with other triggers of myocardial infarction (MI) such as low air temperature, high wind velocity, low atmospheric pressure, and short sunshine duration. Read more at https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236866

https://www.lupop.lu.se/article/association-acute-myocardial-infarction-influenza-nationwide-observational-study - 2025-07-05

Published 17 September 2020 Increased urinary excretion of IgM and low-grade albuminuria are associated with increased risk of cardiovascular morbidity and mortality. The objective of this study was to investigate the association between urinary IgM, albuminuria, and vascular parameters reflecting arterial structure and function. Read more at https://bmccardiovascdisord.biomedcentral.com/articles/

https://www.lupop.lu.se/article/patterns-urinary-albumin-and-igm-associate-markers-vascular-ageing-young-middle-aged-individuals - 2025-07-05

Published 18 September 2020 An inverse relationship between mental health and academic achievement is a well-known phenomenon in the scientific literature. However, how and when this association develops is not fully understood and there is a lack of longitudinal, population-based studies on young children. Early intervention is important if associations are to be found already during childhood. T

https://www.lupop.lu.se/article/mental-health-and-academic-performance-study-selection-and-causation-effects-childhood-early - 2025-07-05

Published 18 September 2020 Intracerebral hemorrhage (ICH) is the most serious adverse effect of oral anticoagulant (OAC) treatment. The effect of OAC reversal therapy on outcome is uncertain. We compared 90-day survival and functional outcome in patients with OAC-ICH who received OAC reversal therapy with those who did not. Read more at https://www.frontiersin.org/articles/10.3389/fneur.2020.0076

https://www.lupop.lu.se/article/reversal-treatment-oral-anticoagulant-related-intracerebral-hemorrhage-observational-study-based - 2025-07-05

Published 16 June 2020 Sport‐related concussions are an increasingly recognized health problem. Soccer is the most popular sport in the world although recent studies on concussion incidence are scarce. Here, a nationwide prospective study on concussion incidence, symptom severity, risk factors, gender differences, and return‐to‐play after concussion was performed in 51 Swedish elite soccer teams d

https://www.lupop.lu.se/article/concussion-incidence-and-recovery-swedish-elite-soccer-prolonged-recovery-female-players - 2025-07-05

Published 16 June 2020 The study population included adults (n = 434,542) aged 30 years or older with DM followed from 2005 to 2015 in Sweden for incident HF. The association between neighborhood deprivation and the outcome was explored using Cox regression analysis, with hazard ratios (HRs) and 95% confidence intervals (95% CIs). All models were conducted in both men and women and adjusted for ag

https://www.lupop.lu.se/article/association-between-neighborhood-deprivation-and-heart-failure-among-patients-diabetes-mellitus-10 - 2025-07-05

Published 15 February 2018 Theme: "The future of Swedish register-based research" By the end of 2018 the Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM), funded by the Swedish Research Council, has been active for 10 years. This will be acknowledged by a free open national one-day symposium in Stockholm 16 May reflecting on how the achievements and experien

https://www.lupop.lu.se/article/10-year-symposium-simsam - 2025-07-05

Published 17 June 2020 Consecutive patients with early RA (symptom duration <12 months) were followed according to a structured programme and examined with dual-energy X-ray absorptiometry (DXA) at inclusion and after 2, 5 and 10 years. Mean Z-scores over the study period were estimated using mixed linear effect models. Changes in Z-scores between follow-up visits were analysed using paired T-test

https://www.lupop.lu.se/article/changes-bone-mineral-density-over-10-years-patients-early-rheumatoid-arthritis - 2025-07-05

Published 17 June 2020 It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. New publication in JAHA

https://www.lupop.lu.se/article/risk-stroke-patients-atrial-fibrillation-associated-stroke-siblings-nationwide-study - 2025-07-05

Published 18 June 2020 We performed whole-exome sequencing in 22 probands, under 56 years at their first ischemic stroke episode, from multi-incident stroke families. With the use of a comprehensive stroke-gene panel, we searched for variants in stroke-related genes. The probands’ clinical stroke subtype was related to clinical characteristics previously associated with pathogenic variants in thes

https://www.lupop.lu.se/article/whole-exome-sequencing-22-young-ischemic-stroke-patients-familial-clustering-stroke - 2025-07-05

Published 18 June 2020 Chills and vomiting have traditionally been associated with severe bacterial infections and bacteremia. However, few modern studies have in a prospective way evaluated the association of these signs with bacteremia, which is the aim of this prospective, multicenter study. Patients presenting to the emergency department with at least one affected vital sign (increased respira

https://www.lupop.lu.se/article/risk-bacteremia-patients-presenting-shaking-chills-and-vomiting-prospective-cohort-study - 2025-07-05

Published 19 June 2020 Disease prevalence proportions were generally underestimated in the absence of IPPW but became markedly closer to population values after IPPW using sociodemographic variables. We found limited evidence of selective participation bias in association estimates, but IPPW improved external validity when bias was present. New publication in Journal of Clinical Epidemiology

https://www.lupop.lu.se/article/participation-weighting-based-sociodemographic-register-data-improved-external-validity-population - 2025-07-05

Published 19 June 2020 Polypharmacy and excessive polypharmacy were evaluated using data extracted from the Swedish Prescribed Drug Register between 2006 and 2014. Polypharmacy was defined as being exposed to five or more drugs and excessive polypharmacy was defined as being exposed to 10 or more drugs during 1 month respectively. Average annual percent change (AAPC) was calculated using Joinpoint

https://www.lupop.lu.se/article/increasing-trend-prevalence-polypharmacy-sweden-nationwide-register-based-study - 2025-07-05

Published 20 June 2020 Obesity among children and adolescents is a worldwide public health concern. Type 1 diabetes (T1D) and type 2 diabetes (T2D) incidence are increasing, with heredity and socioeconomic status as possible risk factors. How these factors affect the risk of childhood obesity remains unclear. The aim of this study was to investigate the association between obesity and parental dia

https://www.lupop.lu.se/article/impact-parental-diabetes-prevalence-childhood-obesity - 2025-07-05

Published 20 June 2020 The world of sports has a complex association to problem gambling, and the sparse research examining problem gambling in athletes has suggested an increased prevalence and particularly high male predominance. The present study aimed to study frequency and correlates of problem gambling in populations with moderate to high involvement in fitness or physical exercise. New publ

https://www.lupop.lu.se/article/problem-gambling-fitness-world-general-population-web-survey - 2025-07-05

Published 21 June 2020 The aim of this study was to investigate the risk of developing preeclampsia (PE) associated with gestational exposure to ambient air pollutants in southern Sweden, a low-exposure area. We used a cohort of 43,688 singleton pregnancies and monthly mean exposure levels of black carbon (BC), local and total particulate matter (PM2.5 and PM10), and NOX at the maternal residentia

https://www.lupop.lu.se/article/maternal-exposure-ambient-air-pollution-and-risk-preeclampsia-population-based-cohort-study-scania - 2025-07-05

Published 21 June 2020 Due to the demographic challenge in most countries it is important to consider making work life sustainable. A sustainable work life is of importance in all age groups when working life will be extended to a higher age. New publication in Applied Ergonomics

https://www.lupop.lu.se/article/sustainable-working-life-all-ages-swage-model - 2025-07-05