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Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (6
Many hand-held or mixed reality devices are used with a single sensor for 3D reconstruction, although they often comprise multiple sensors. Multi-sensor depth fusion is able to substantially improve the robustness and accuracy of 3D reconstruction methods, but existing techniques are not robust enough to handle sensors which operate with diverse value ranges as well as noise and outlier statistics
The Petit Larousse illustré is a French dictionary first published in 1905. Its division in two main parts on language and on history and geography corresponds to a major milestone in French lexicography as well as a repository of general knowledge from this period. Although the value of many entries from 1905 remains intact, some descriptions now have a dimension that is more historical than cont
Background: Somatostatin receptor 68Ga PET imaging is standard for evaluation of a patient’s suitability for 177Lu peptide receptor radionuclide therapy of neuroendocrine tumours (NETs). The 68Ga PET serves to ensure sufficient somatostatin receptor expression, commonly evaluated qualitatively. The aim of this study is to investigate the quantitative relationships between uptake in 68Ga PET and ab
Background: Traditional risk factors for atherosclerotic disease (AD) are well-known, of which some are relevant also for abdominal aortic aneurysms (AAA). The present study compares the importance of plasma biomarkers and traditional risk factor profiles for incident AD without concomitant AAA (isolated AD) and AAA without concomitant AD (isolated AAA) during long-term follow-up. Methods: In the
Avoidance maneuvers at normal driving speed or higher are demanding driving situations that force the vehicle to the limit of tire–road friction in critical situations. To study and develop control for these situations, dynamic optimization has been in growing use in research. One idea to handle such optimization computations effectively is to divide the total maneuver into a sequence of sub-maneu
Background: Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are imputed is fundamental. Several accuracy measures have been proposed and some are implemented in imputation software, unfortunately diversely across platforms. In the present paper,
Through a historization of the Swedish public sector together with vignettes grounded in interviews, this paper questions managerialism in the public sector. The chapter argues for leaderless management as a shift of attention from managerialism toward worker control. The chapter explores what nurses identify as central areas of conflict shaping their work, and what forms of change they view as ne
The study investigates the effect of Portland cement and ground granulated blast furnace slag (GGBFS) added in changed proportions as stabilising agents on soil parameters: uniaxial compressive strength (UCS), Proctor compactness and permeability. The material included dredged clayey silts collected from the coasts of Timrå, Östrand. Soil samples were treated by different ratio of the stabilising
The HIBEAM/NNBAR experiment is a free-neutron search for n → sterile n and n → n¯ oscillations planned to be installed at the European Spallation Source under construction in Lund, Sweden. A key component in the experiment is the detector to identify n - n¯ annihilation events, which will produce on average four pions with a final state invariant mass of two nucleons, around 1.9 GeV. The beamline
In coherent control schemes, pathways connecting an initial and a final state can be independently controlled by manipulating the complex amplitudes of their transition matrix elements. For paths characterized by the absorption of multiple photons, these quantities depend on the magnitude and phase between the intermediate steps, and are expected to be strongly affected by the presence of resonanc
Cholesterol is a lipid molecule of great biological importance to animal cells. Dysregulation of cholesterol metabolism leads to raised blood total cholesterol levels, a clinical condition called hypercholesterolemia. Evidence has shown that hypercholesterolemia is associated with the development of liver and heart disease. One of the mechanisms underlying heart and liver alterations induced by hy
Robust feature correspondences between 2D sonar imagery are important for perception tasks in the underwater domain such as 3D reconstruction but involve open challenges, in particular, low-resolution as well as the fact that object appearance is view-dependent. Although sonars in the MHz range would allow for higher resolution imagery, in this paper we focus on scenarios with a lower frequency kH
Background: The number of people with a migration background and dementia is increasing in Europe. All patients with suspected dementia have the right to an appropriate cognitive assessment and correct diagnosis for optimal treatment and support. Rowland Universal Dementia Assessment Scale (RUDAS) cognitive screening instrument is less affected by language, culture, and educational background, and
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci. Cross-ancestry meta-analysis with a
John-Paul Himka’s new book, Ukrainian Nationalists and the Holocaust: OUN and UPA’s Participation in the Destruction of Ukrainian Jewry, 1941-1944, represents a milestone in research on the complicity of the OUN-UPA in the Holocaust. Based on decades worth of research in dozens of archives around the world, Himka makes a well-documented and indisputable case for Ukrainian nationalist involvement i
Quantum control is implemented in a 2-beam fs/ns rotational CARS setup via a second control pulse with variable delay. The potential of the concept for improved diagnostics is demonstrated by species-selective enhancement/annihilation via field-free alignment.
Jet impingement cooling is an effective way for thermal management in electronics, prevailed over many other single heat transfer modes. In general, jet arrays are better than a single jet, enhancing jet cooling performance. However, the performance of jet arrays is strongly dependent on the jet configurations, e.g., adjacent jet interval and hole-to-surface distance. Thus, in this study, jet impi
INTRODUCTION Women and their families are often excluded from reproductive decisionmaking processes in postnatal care, and do not know which choices they have. Shared decision-making is a critical but challenging component of maternity care quality. The aim was to explore women's experience of the decision-making process about early return from hospital with home-based postnatal midwifery care. ME
