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The heme and radical scavenger α1-microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage

Background: Germinal matrix intraventricular hemorrhage (GM-IVH) is associated with cerebro-cerebellar damage in very preterm infants, leading to neurodevelopmental impairment. Penetration, from the intraventricular space, of extravasated red blood cells and extracellular hemoglobin (Hb), to the periventricular parenchyma and the cerebellum has been shown to be causal in the development of brain i

Stronger activation of spatial representations of words by presentation of gestures in absence of spatial task

Speech and gestures express meaning together, connecting lexical and visuo-spatial representations in the speaker’s mind. Several studies have demonstrated uptake of spatial information from gestures however usually following explicit instructions to recreate or recall spatial features, deviating from typical listening situations. It remains unclear whether exposure to gestures activates spatial r

Isolation of plaice (Pleuronectes platessa) α1-microglobulin : Conservation of structure and chromophore

A cDNA coding for plaice (Pleuronectes platessa) α1-microglobulin (Leaver et al., 1994, Comp. Biochem. Physiol. 108B, 275-281) was expressed and purified from baculovirus-infected insect cells. Specific monoclonal antibodies were then prepared and used to isolate the protein from plaice liver and serum. Mature 28.5 kDa α1-microglobulin was found in both liver and serum. The protein consisted of an

Nominal and Real Effective Exchange Rates for Europe, 1870-2016 : Some methodological issues

This paper presents and discusses a new database on nominal and real effective exchange rates for an extensive range of European countries spanning 1870-2016. Indeed, with the exception of a few countries, such long run historical series have not been previously constructed. To gage the validity of these series, comparisons with the BIS and IMF indices are conducted. In addition to stretching furt

Implications of a shrinking Great Salt Lake for dust on snow deposition in the Wasatch Mountains, UT, as informed by a source to sink case study from the 13-14 April 2017 dust event

The deposition of dust on snow accelerates melt by perturbing snow albedo, directly by darkening the snow surface and indirectly by enhancing snow grain growth. The snow darkening process impacts hydrology by shifting runoff timing and magnitude. Dust on snow deposition has been documented in the Wasatch Mountains, snowmelt from which accounts for up to 80% of surface water supply for Salt Lake C

Impacts of increasing aridity and wildfires on aerosol loading in the intermountain Western US

Feedbacks between climate warming, land surface aridity, and wildfire-derived aerosols represent a large source of uncertainty in future climate predictions. Here, long-term observations of aerosol optical depth, surface level aerosol loading, fire-area burned, and hydrologic simulations are used to show that regional-scale increases in aridity and resulting wildfires have significantly increased

Climatology of new particle formation and corresponding precursors at storm peak laboratory

Thirteen years of measurements of ultrafine (3-10 nm diameter) aerosols are presented from a remote high elevation (3210 m a.s.l.) site in Colorado, Storm Peak Laboratory. Previous work has shown that frequent new particle formation (NPF) occurs regularly at the site (52% of days). This long-term climatology of ultrafine aerosols clearly shows a seasonal dependence on new particle formation at Sto

Contributions of dust and biomass burning to aerosols at a Colorado mountain-top site

Visible Multifilter Rotating Shadowband Radiometer (vis-MFRSR) data were collected at Storm Peak Laboratory (SPL), a mountain-top facility in northwest Colorado, from 1999 to 2011 and in 2013. From 2011 to 2014, in situ measurements of aerosol light scattering were also obtained. Using these data sets together, the seasonal impact of dust and biomass burning is considered for the western USA. Anal