Long-term right ventricular pacing is associated with left ventricular dysfunction and cardiomyopathy, particularly in pediatric patients and those with congenital heart disease (CHD). Research has shown that pacing-induced cardiomyopathy can be reversed with nonselective or selective His bundle pacing in adults, however, the information available about the use of this type of therapy in pediatric

The composition of serum proteins is reflecting the current health status and can, with the right tools, be used to detect early signs of disease, such as an emerging cancer. An earlier diagnosis of cancer would greatly increase the chance of an improved outcome for the patients. However, there is still an unmet need for proficient tools to decipher the information in the blood proteome, which cal

Biofuels are still too costly to compete in the energy market and it has been suggested that low-value feedstocks could provide an opportunity for the production of low-cost biofuels; however, the lower quality of these feedstocks requires the introduction of a conditioning step in the biorefinery process. The aim of this study was to evaluate whether feedstock savings cover the cost of conditioni

Background: Poor health and unmet healthcare needs is common among people with substance use disorder (SUD) including patients in opioid substitution treatment (OST). Low health literacy (HL) is associated with poverty, low education and physical limitations, but is unexplored in an OST context. Methods: Mixed-methods were used. Participants were consecutively recruited by clinic staff or research

BACKGROUND: Maldescended testes or cryptorchidism is a genital birth defect that affects 2-9% of all male new-borns. Over the last 40 years there have been reports of increased prevalence in countries like the US, the UK and the Scandinavian countries. This possible increase has in some studies been linked to a foetal exposure to chemical pollutants. In this matched case-control study, we analysed

Great social challenges of today no longer come one by one. What makes them great is their ever-greater entanglement in one other and across multiple levels, including landscapes, regimes and niches. To this background, a major challenge facing many countries today is how to successfully address issues of interlocking problems of unsustainability caused by cultural contingents. We argue that while

Objectives: Distal cholangiocarcinoma (dCCA) is a malignancy with a dismal prognosis. One of the hallmarks is the presence of a rich desmoplastic stroma believed to contribute to tumor progression and treatment resistance. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein implicated in tumor-stroma interaction with prognostic correlation across several malignanci

Purpose: In this study, numerical simulations are performed to compare the adiabatic film cooling effectiveness and reveal the difference of film cooling mechanisms of two models with the same geometries and cross-section areas of film holes’ exits at three typical blowing ratios (M = 0.5, 1 and 1.5). The two models are an elliptical model and a cylindrical model with 90° compound angle, respectiv

2020’s spring term was dramatic. Don’t get me wrong, I do enjoy some drama, and our U-turn from classroom to online teaching had some dramatic flair. There was a definite sparkle of ‘Yes we can’ (over more damp notes of panic in the online teaching novice – ‘how does that work? Why does everything take so long?’).While I learned to handle the basics of preparing a video lecture, other forms of dra

BACKGROUND: Arteriosclerosis is prevalent in patients with chronic kidney disease (CKD). Our aims were to investigate (1) the effects of 12 months of either balance- or strength- both in combination with endurance training on abdominal aortic calcification (AAC); on some lipids and calcific- and inflammatory markers; and (2) the relationships between the change in AAC score and these markers in no

Policy (or political) entrepreneurship (PE) is an actor-based framework to examine and understand policy change. Rooted in Kingdon’s (1984/2003) Multiple Streams approach (MSA), the policy entrepreneur is defined as “a special kind of actor, embedded in the sociopolitical fabric, who is alert to opportunities and acts upon them; he or she amasses coalitions for the purpose of effecting change in a

Different host species often differ considerably in susceptibility to a given pathogen, but the causes of such differences are rarely known. The natural hosts of the tick-transmitted bacterium Borrelia afzelii, which is one of causative agents of Lyme borreliosis in humans, include a variety of small mammals like voles and mice. Previous studies have shown that B. afzelii-infected bank voles (Myod

Objectives: Parkinson's disease (PD) features both motor and non-motor symptoms that substantially impact quality of life (QoL). Levodopa-carbidopa intestinal gel (LCIG) reduces motor complications and improves some non-motor symptoms in advanced PD (APD). Change in patients' health-related quality of life (hrQoL) is a common endpoint in PD trials and has become an important factor in judging over