Cardiovascular disease (CVD) is the leading cause of death globally. Inflammatory cardiomyopathies can be life-threatening, and the underlying mechanisms are not fully understood. This thesis aimed to investigate the underlying mechanisms driving the pathogenesis of myocarditis and septic cardiomyopathy, and to explore potential treatment strategies. In particular, we focused on the pro-inflammato

Background: Autistic persons exhibit poorer body awareness than neurotypical persons. Movement quality may be regarded as an expression of body awareness. Therefore, sound assessments of movement quality are essential to make reliable decisions about body awareness interventions.Purpose: To assess measurement properties of the Body Awareness Scale Movement Quality (BAS MQ) in persons on the autism

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by the accumulation of β-amyloid (Aβ) peptides and phosphorylated tau (P-tau) proteins in the brain, leading to cognitive decline and memory impairment. Despite extensive research, the exact mechanisms of AD pathogenesis remain elusive, and reliable biomarkers for early diagnosis and disease monitoring are still ne

Vägskyltar används i stor utsträckning på trafikerade vägar för att vägleda trafikanter i rätt riktning. För att optimera materialåtgången och minska kostnaderna krävs effektiva dimensioneringsverktyg som kan effektivisera arbetet med att dimensionera de bärande konstruktionerna. Detta arbete syftar till att utveckla ett beräkningsverktyg för den bärande konstruktionen till vägskyltar. Den bärand

The last twenty years have seen 3D documentation and modelling emerge as an important vector for methodological innovation in cutting-edge research in archeology. Adopting techniques such as photogrammetric modelling and laser scanning, archeologists are experimenting with new ways of producing and communicating knowledge; and they do so by innovating and developing new ways to record, report, and

Background: Accurate characterization of newly diagnosed a solid adnexal lesion is a key step in defining the most appropriate therapeutic approach. Despite guidance from the International Ovarian Tumor Analyzes Panel, the evaluation of these lesions can be challenging. Recent studies have demonstrated how machine learning techniques can be applied to clinical data to solve this diagnostic problem

Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). The PEXIVAS (Plasma Exchange and Glucocorticoids in Severe Antineutrophil Cytoplasmic Antibody-Associated Vasculitis) (NCT00987389) trial was the largest in AAV and the first to enroll participants with DAH requiring mechanical ventilation. Objectives

Affärsrättsligt Centrum vid Lunds universitet (ACLU) bedriver forsknings- och seminarieverksamhet på centrala förmögenhetsrättsliga områden. En viktig del av den verksamhet som bedrivs inom ACLU är att regelbundet publicera böcker som består av originalbidrag från forskare och praktiker som har anknytning till ACLU. Målsättningen för ACLU:s publikationer är att de ska belysa aktuella och praktiskt

Compared to its urban counterpart, the rural often lacks access to public services. In the global north, this rural-urban divide is said to result in rural areas being perceived as neglected. The concept of geography of discontent investigates this feeling of being left behind, saying it leads to a lower level of trust in political institutions. Similarly, the OECD concludes in their research that

The paper examines how the increasing datafication of society and advancements in artificial intelligence (AI) offer new empirical opportunities to better understand the Minimum Content of Nationality (MCN). Despite the critical importance of the MCN in statelessness, it has largely been ignored in academic and policy circles. The ambiguity that results from this lack of engagement greatly complic

BACKGROUND: Despite pain control being a top priority in end-of-life care, pain continues to be a troublesome symptom and comprehensive data on pain prevalence and pain relief in patients with different diagnoses are scarce.METHODS: The Swedish Register of Palliative Care (SRPC) was used to retrieve data from 2011 to 2022 about pain during the last week of life. Data were collected regarding occur

BACKGROUND AND AIM: In many places worldwide there is an ongoing urbanization, often achieved through densification. An increased number of inhabitants in an area often leads to both increased traffic and placement of new buildings closer to roads, and thus increased population exposure to road traffic noise. The aim of the study was to estimate and compare the health impacts of road traffic noise

Searches for exclusive decays of the Higgs boson into D⁎γ and of the Z boson into D0γ and Ks0γ can probe flavour-violating Higgs boson and Z boson couplings to light quarks. Searches for these decays are performed with a pp collision data sample corresponding to an integrated luminosity of 136.3 fb−1 collected at s=13TeV between 2016–2018 with the ATLAS detector at the CERN Large Hadron Collider.

Obstructive sleep apnea (OSA) is characterized by repeated episodes of upper airway obstruction during sleep, and it is closely linked to several cardiovascular issues due to intermittent hypoxia, nocturnal hypoxemia, and disrupted sleep patterns. Pulmonary hypertension (PH), identified by elevated pulmonary arterial pressure, shares a complex interplay with OSA, contributing to cardiovascular com

BACKGROUND: Obesity rates have nearly tripled in the past 50 years, and by 2030 more than 1 billion individuals worldwide are projected to be obese. This creates a significant economic strain due to the associated non-communicable diseases. The root cause is an energy expenditure imbalance, owing to an interplay of lifestyle, environmental, and genetic factors. Obesity has a polygenic genetic arch

Measurements of the pT-dependent flow vector fluctuations in Pb-Pb collisions at sNN=5.02TeV using azimuthal correlations with the ALICE experiment at the Large Hadron Collider are presented. A four-particle correlation approach [ALICE Collaboration, Phys. Rev. C 107, L051901 (2023)2469-998510.1103/PhysRevC.107.L051901] is used to quantify the effects of flow angle and magnitude fluctuations separ

This paper presents a search for pair production of higgsinos, the supersymmetric partners of the Higgs bosons, in scenarios with gauge-mediated supersymmetry breaking. Each higgsino is assumed to decay into a Higgs boson and a nearly massless gravitino. The search targets events where each Higgs boson decays into Formula Presented, leading to a reconstructed final state with at least three energe

Background The adverse health effects associated with long commutes provides additional evidence of the commuting paradox. Better job opportunities and higher incomes in larger local labour markets are offset by the negative consequences of longer commutes including lower levels of life satisfaction. Long commutes extend the work day and time spent commuting is time lost for health beneficial actiThe adverse health effects associated with long commutes provides additional evidence of the commuting paradox. Better job opportunities and higher incomes in larger local labour markets are offset by the negative consequences of longer commutes including lower levels of life satisfaction. Long commutes extend the work day and time spent commuting is time lost for health beneficial activities such