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Live-cell super-resolution microscopy enables the imaging of biological structure dynamics below the diffraction limit. Here we present enhanced super-resolution radial fluctuations (eSRRF), substantially improving image fidelity and resolution compared to the original SRRF method. eSRRF incorporates automated parameter optimization based on the data itself, giving insight into the trade-off betwe

Optical microscopy is an indispensable tool in life sciences research, but conventional techniques require compromises between imaging parameters like speed, resolution, field of view and phototoxicity. To overcome these limitations, data-driven microscopes incorporate feedback loops between data acquisition and analysis. This review overviews how machine learning enables automated image analysis

The node of Ranvier is the key element in saltatory conduction along myelinated axons, but its specific protein organization remains elusive in the human species. To shed light on nanoscale anatomy of the human node of Ranvier in health and disease, we assessed human nerve biopsies of patients with polyneuropathy by super-resolution fluorescence microscopy. We applied direct stochastic optical rec

Regionalekonomiska skillnader och varierad befolkningsutvecklinghar under lång tid präglat Sveriges samhällsdynamik. Genom enhistoriskanalys från 1860-talet och framåt visar denna rapport hurregional ojämlikhet i Sverige tidvis har ökat och tidvis har minskat.Den ekonomiska tillväxten har sedan 1980 främst gynnat större regioneri ekonomisk- och befolkningsbemärkelse, medan mindre områdenhalkat eft

Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hyperglycaemia. In spite of vigorous efforts to elucidate the pathogenetic origins and natural course of the disease, there is still a lack of biomarkers and tools for prevention, disease stratification and t

BACKGROUND AND PURPOSE: Periprosthetic joint infection (PJI) after elbow arthroplasty is a serious complication. Evidence of the best antibiotic prophylaxis for elbow arthroplasty is lacking. We aimed to investigate the regimens presently used in Sweden, incidence of PJI, and the bacteria most frequently found in elbow PJI.METHODS: A questionnaire was sent out to all Swedish units performing elbow

Postgraduate education has been recognised as a key to bring about societal change. While further capacity building is imperative in this regard in East Africa (Wao et al., 2022), we will in this study focus on how supervisors function as important role models to their students (Brodin et al., 2020). We assume that supervisors’ own approaches to societal change affect their supervisor relationship

Kroppen har relevans för psykologi. Den är basen, alltid i bakgrunden av våra upplevelser, våra sinnestillstånd, och den är därmed alltid med i bakgrunden av psykopatologiska tillstånd. En bättre förståelse för kroppens betydelse för vår tillvaro och vårt varande är en första utgångspunkt. Ett huvudargument som förs i avhandlingen är att om psykopatologiska tillstånd som berör ens kroppslighet skaThe body holds relevance for psychology. The body is the basis, always in the background of our experiences, our states of mind, and therefore always in the background of psychopathological conditions.A better understanding of the body's significance is a first starting point. A main argument made in the thesis is that if we sincerely want to understand psychopathological states we need some basic

AIMS/HYPOTHESIS: Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance from one parent or parental bias. Most studies of these phenomena have focused on adult populations. We aimed to investigate the heritability and parent-of-origin effects on cardiometabolic traits in a birth cohort with serial measurements to determine whether

BACKGROUND: Few studies have explored the association between DNA methylation and physical activity. The aim of this study was to evaluate the association of objectively measured hours of sedentary behavior (SB) and moderate physical activity (MPA) with DNA methylation. We further aimed to explore the association between SB or MPA related CpG sites and cardiometabolic traits, gene expression, and

BACKGROUND: Mitigation measures implemented in response to the COVID-19 pandemic led to significant changes in maternity care across Europe, including restrictions on companions during labor and birth. This cross-sectional study explores the association between the presence of a companion of choice and a positive perception of the birth experience. Additionally, it explores the association between

Overview: Prostate cancer (PC)is the most common cancer in Sweden, and the leading cause of cancer death. Positronemission tomography with x-ray computed tomography (PET/CT) is an important imagingmethod for many cancers. A group of PET radiopharmaceuticals known as PSMA(prostate specific membrane antigen) ligands has been introduced for imaging ofPC. This thesis investigates aspects of the ligand

The legal form dictates the contours of law’s appearance. Texts are neatly divided into (often) numbered paragraphs. Pages must conform to specified layouts. Conventions regulate the use of fonts, punctuation and colours. Legal terms of art replace colloquial expressions. Human experiences enter legal texts only in mediated, sanitized forms. The dictats of legal form are all but incidental. They c

The current linear economic system is based on the extraction of natural resources, the transformation of raw materials and the disposal of waste, leading to the environmental and economic depletion of resources and society. The circular economy proposes the circularity of materials, evaluating post-consumption waste and proposing a waste hierarchy called preparation for reuse (PfR), as set out in

When applied to vertebrate vocalizations, source-filter theory, initially developed for human speech, has revolutionized our understanding of animal communication, resulting in major insights into the form and function of animal sounds. However, animal calls and human nonverbal vocalizations can differ qualitatively from human speech, often having more chaotic and higher-frequency sources, making