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Background: Postinfectious autoimmune processes have been proposed as potential causal risk factors for obsessive-compulsive disorder (OCD). In this large population-based study, we aimed to clarify the familial coaggregation pattern between severe infections and OCD across clusters of relatives with varying degrees of relatedness. Methods: We identified 4,916,898 individuals born in Sweden betwee

Time-frequency reassignment, commonly used to analyze time-varying signals, is a post-processing method that sharpens time-frequency representations. However, the reassignment method is sensitive to noise, making it unsuitable for time-frequency analysis when the signal-to-noise ratio is low. To increase the robustness of the reassignment technique, we develop a novel reassigned multitaper spectro

Refugee entrepreneurship emerged as a distinct area of inquiry, delving into the complex relationship between experiences of conflict, forced displacement, and entrepreneurial behaviour. However, an inconsistent and fragmented literature that lacks a unified understanding hinders this emerging stream. To tackle this issue, this chapter engages in a scholarly endeavour to conceptualise refugee entr

Introduction: Health-promotion approaches to address stress-related exhaustion disorders, reduce personal suffering, improve coping and participation in everyday life are needed in primary care. The aim of this study was to investigate self-reported health and well-being before and after an intervention focusing on well-being with photo-supported conversations (BeWellTM). Material and methods: Eig

• Purpose: To assess whether distal radius fracture (DRF) malunion is associated with greater patient-reported disability. • Methods: We searched PubMed, EMBASE, and Cochrane databases up to 21 May 2023. Two reviewers independently screened retrieved titles/abstracts and assessed the full text of potentially eligible articles to identify cohort studies and randomized controlled trials reporting ou

Jes Wienberg gick i pension våren 2025 efter att under många år ha varit knuten till institutionen för arkeologi och antikens historia vid Lunds universitet. I den här boken adresserar trettionio författare lika många ämnen och forskningsproblem, varav många anknyter till de område som alltid varit i fokus för Jes intresse, det kyrkliga kulturarvet i vid mening. Men här finns även artiklar om kast

Developments in ambulatory electrocardiogram (ECG) technology have led to vast amounts of ECG data that currently need to be interpreted by human technicians. Here we tested an artificial intelligence (AI) algorithm for direct-to-physician reporting of ambulatory ECGs. Beat-by-beat annotation of 14,606 individual ambulatory ECG recordings (mean duration = 14 ± 10 days) was performed by certified E

Misfolding, self-assembly, and subsequent deposition of amyloid β plaques and tau tangles are closely associated with Alzheimer’s disease (AD) and its neurodegenerative processes, driving healthy neurons into a diseased state. At present, AD is the most widespread form of dementia, causing profound personal and familial hardship as well as imposing a substantial societal economic burden.Currently,The purpose of the work that forms the basis of this thesis has been to investigate fundamental properties of amyloid β and tau self-assembly and their solubility. The results of this research are presented as five research articles. In Paper I, a solubility assay for determining the solubility of amyloid proteins is developed and its use demonstrated for the Aβ40 peptide. Paper II finds that tau

The Collisional Orogeny in the Scandinavian Caledonides (COSC) project focuses on processes related to the closure of the Iapetus Ocean, causing the Ordovician–Silurian continent– continent collision between Baltica and Laurentia. The rock succession in the second drill core (COSC-2) from the Jämtland County, central Sweden, provides the base for detailed sedimentological, stratigraphic, geophysic

Cities typically treat migration and sustainability as separate policy domains. When migration is highlighted in the context of sustainability in urban destination areas, it is typically understood to have no, or at worst, negative impacts on sustainability. As a result, migration and migrants are commonly left out of sustainability policy and planning. Here, we present emerging evidence to refram

Antibodies and avidity maturation contribute to long-lasting immunity, and previous COVID-19 seems to enhance the immune response after vaccination. The aim of this study was to compare the immune response after vaccination between COVID-19 convalescents and naïve patients. Blood samples from COVID-19 convalescents and naïve patients, taken 1, 3 and 6 months after the second dose of vaccine (mRNA-

Psychedelic-assisted therapy is becoming increasingly acknowledged as an effective therapeutic intervention for various psychiatric illnesses. However, the evaluation of masking success is rarely reported in trials. The objective of the present systematic review was to evaluate placebo-control and masking in studies exploring psychedelic-assisted therapy. Nine (k = 9) studies dating between Januar

Trafficking in human organs, cells, and tissues has long been a source of concern for health authorities and professionals, and several international ethical guidance documents and national laws have affirmed the prohibition of trade in these substances of human origin (SoHOs). However, despite considerable attention to the issue of organ trafficking, this remains a substantial and widespread prob

Recension av Karin Westin Tikkanens bok Latin: handbok i odödlighet

In this article, square-root formulations of the statistical linear regression filter and smoother are developed. Crucially, the method uses QR decompositions rather than Cholesky downdates. This makes the method inherently more numerically robust than the downdate based methods, which may fail in the face of rounding errors. This increased robustness is demonstrated in an ill-conditioned problem,

Effective preprocessing of electroencephalography (EEG) data is fundamental for deriving meaningful insights. Independent component analysis (ICA) serves as an important step in this process by aiming to eliminate undesirable artifacts from EEG data. However, the decision on which and how many components to be removed remains somewhat arbitrary, despite the availability of both automatic and manua

Background: When a potential stem cell donor to a seriously ill child is a healthy sibling below 18 years, Swedish parents have the legal right and obligation to decide on behalf of the donor child. However, there are potentially conflicting loyalties when parents have one severely ill child in need for a cure and one healthy child who will be subjected to medical procedures. This study explored p