Search results

Filter

Filetype

Your search for "*" yielded 533048 hits

Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle : A UK Biobank study

Aims: Brisk walking and a greater muscle strength have been associated with a longer life; whether these associations are influenced by other lifestyle behaviours, however, is less well known. Methods: Information on usual walking pace (self-defined as slow, steady/average, or brisk), dynamometer-assessed handgrip strength, lifestyle behaviours (physical activity, TV viewing, diet, alcohol intake,

Strain Rate Effects on Tensile and Compression Behavior of Nano-crystalline Nanoporous Gold: A Molecular Dynamic Study

In this study the strain rate effects on the tensile and compressive properties of nano-crystalline nanoporous gold (nc-NPAu) are investigated by performing molecular dynamics simulations. In order to examine the role of strain rate,atomistic models of nc-NPAu structures with three different grain size are generated through a novel modeling technique based on the Voronoi tessellation method. AdditIn this study, strain rate effects on the tensile and compressive properties of nano-crystalline nanoporous gold (nc-NPAu) are investigated by performing molecular dynamics simulations. For this purpose, atomistic models of nc-NPAu structures with three different grain sizes are generated through a novel modeling technique based on the Voronoi tessellation method. Additionally, an adaptive common

Shear anisotropy in Si-Cu interfaces on the atomic scale

Three dimensional molecular dynamics (MD) is used to model the mechanical response at the interface between a thin Cu coating resting on a base of Si. The copper coating is subjected to a displacement controlled shear load and the atom movements at the Si-Cu interface are monitored to investigate the effects of crystallographic anisotropy. The two crystals have the same crystallographic orientatio

Molecular dynamics modelling of metric scaling effects in nanosized Cu beams holding a grain boundary

Here we investigate the influence from a centrally placed grain boundary in nano-sized beams of Cu subjected to tensile loading normal to the grain boundary. Also the influence of the cross section size of the beams are investigated. The crystallographic orientations in the grains are [100], [110] or [111], and the results are compared to those of single crystal beams. The investigation is perform

The red blood cell count and the erythrocyte sedimentation rate in the diagnosis of polycythaemia vera

BACKGROUND: Iron deficiency in polycythaemia vera (PV) may impact the validity of the haematocrit (HCT), since HCT is red blood cell count (RBC) × mean corpuscular volume (MCV).OBJECTIVES: To investigate (a) the effect of microcytosis on HCT, (b) the erythrocyte sedimentation rate (ESR) as a possible additional diagnostic marker for PV.MATERIAL AND METHODS: This study included 182 subjects: 39 wit

Biologics beyond TNF-α inhibitors and the effect of targeting the homologues TL1A-DR3 pathway in chronic inflammatory disorders

A number of anti-tumor necrosis factor alpha (TNF-α) biologics have been developed in recent years, such as adalimumab, etanercept, and infliximab for the treatment of chronic inflammatory disorders like rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis and several other novel drugs that target TNF-α signaling are still being developed. Indeed, blockade of this pathway see

ESTRO ACROP consensus guideline on the use of image guided radiation therapy for localized prostate cancer

Use of image-guided radiation therapy (IGRT) helps to account for daily prostate position changes during radiation therapy for prostate cancer. However, guidelines for the use of IGRT are scarce. An ESTRO panel consisting of leading radiation oncologists and medical physicists was assembled to review the literature and formulate a consensus guideline of methods and procedure for IGRT in prostate c

ABCB1 single-nucleotide variants and survival in patients with glioblastoma treated with radiotherapy concomitant with temozolomide

Standard treatment for glioblastoma (GBM) patients is surgery and radiochemotherapy (RCT) with temozolomide (TMZ). TMZ is a substrate for ABCB1, a transmembrane drug transporter. It has been suggested that survival for GBM patients receiving TMZ is influenced by different single-nucleotide variants (SNV) of ABCB1. We therefore examined SNV:s of ABCB1, namely 1199G>A, 1236C>T, 2677G>T/A, and 3435C>

Comparison of the Regenerative Potential for Lung Tissue of Mesenchymal Stromal Cells from Different Sources/Locations Within the Body

Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proTo date, bone marrow-derived mesenchymal stromal cells (MSCs) have been considered the golden standard among MSC cell-based therapies. However, the harvesting of bone marrow is a highly invasive procedure and the number of MSCs isolated is low, and it declines with increasing age. MSCs with immune-regulatory and regenerative properties can be isolated from many different tissues; however, bone mar

Clinical Application of Stem/Stromal Cells in COPD

Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proChronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies pro

Crisis and Public Support for the Euro, 1990–2014

This article analyses the evolution of public support for the single European currency, the euro, from 1990 to 2014 for a 12-country sample of the euro area (EA-12), focusing on the most recent period of the financial and sovereign debt crisis, starting in 2008. We find that citizens’ support for the euro on average was marginally reduced during the first six years of the crisis, and that support

Seven Senses of the City : Urban Spacetime and Sensory Memory in Contemporary Sinophone Fiction

The objective of this dissertation is to investigate the narrative mechanisms and imagery that fictional works employ to conceptualize and communicate complex human experiences of space, time and memory. Furthermore, this study shows how contemporary cities change the way we think about such basic concepts by analyzing narratives that employ and encourage multisensory, spatiotemporal understanding

Performing ambiguous policy : How innovation events simultaneously perform change and collaborative order

The aim of this article is to analyse how innovation policy is staged and legitimised through the dramatised social process of an event. The context is taken from an annual event, Skåne Innovation Week, which is arranged by the regional innovation system in Skåne, Sweden. Innovation systems often organise similar events internationally, which appear to play a key role in performing inter-organisat

Railway network design and regional labour markets in Sweden

Investment in railways, and transport infrastructure in general, are often motivated because they are believed to improve peoples’ accessibility to jobs. By linking together and increasing the size of labour markets, the matching between individuals and jobs is improved, and the productivity increases. Communities and municipalities lobby for investments that lead to higher accessibility and those

Optical band gap analysis of soot and organic carbon in premixed ethylene flames: Comparison of in-situ and ex-situ absorption measurements

The similarity of in-situ and ex-situ absorption/extinction properties was found by comparing data sets obtained in premixed flat ethylene flames (C/O = 0.77); both ex-situ absorption measurements at CNR of Naples and in-situ laser extinction/absorption measurements at Lund University. The optical band gap analysis was performed as a method to separate/evaluate the contributions to the UV–Visible