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Simulation of nanometric cutting using molecular dynamics

The aim of this work is to perform molecular dynamic simulations of nanometric cutting on single crystal copper with a diamond tool in orderto investigate the dependence of crystallographic orientation and cutting speeds on the cutting forces, machined surface and temperature. It wasfound that the temperature in the substrate, locally and globally, increased for increasing velocity. A higher degre

Improved Tribotesting for Sheet Metal Forming

A new tribotester has been developed to characterize the friction conditions in sheet metal forming applications. The basic principle for the tribotester is parallel strip drawing. This apparatus is an improvement on conventional test setups in that it offers controllable speed and normal load during experimenting, a tool size that is variable over a wide range, and direct force measurement to all

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival

Fell-Muir Lecture : Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour

In the 25 years, as the first of the syndecan family was cloned, interest in these transmembrane proteoglycans has steadily increased. While four distinct members are present in mammals, one is present in invertebrates, including C. elegans that is such a powerful genetic model. The syndecans, therefore, have a long evolutionary history, indicative of important roles. However, these roles have bee

Quantification of the value of structural health monitoring information for fatigue deteriorating structural systems

This paper addresses the quantification of the value of structural health monitoring (SHM) before its implementation for structural systems on the basis of its Value of Information (VoI). The value of SHM is calculated utilizing the Bayesian pre-posterior decision analysis modelling the structural life cycle performance, the integrity management and the structural risks. The relevance and precisio

Presence of Maximal Characteristic Time in Photoluminescence Blinking of MAPbI3 Perovskite

Photoluminescence (PL) blinking is a common phenomenon in nanostructured semiconductors associated with charge trapping and defect dynamics. PL blinking kinetics exhibit very broadly distributed timescales. The traditionally employed analysis of probability distribution of ON and OFF events suffers from ambiguities in their determination in complex PL traces making its suitability questionable. He

On an Integral Identity

We give three elementary proofs of a nice equality of definite integrals, recently proven by Ekhad, Zeilberger, and Zudilin. The equality arises in the theory of bivariate hypergeometric functions, and has connections with irrationality proofs in number theory. We furthermore provide a generalization together with an equally elementary proof and discuss some consequences.

Translation and initial validation of the occupational balance questionnaire to Arabic—Occupational Balance Questionnaire-A

Introduction: Occupational balance (OB) is related to many health indicators, including quality of life. The Occupational Balance Questionnaire (OBQ11) was developed to measure OB, and to date, no Arabic translations of the questionnaire exist. The aim of the study was to describe the translation process of OBQ11 to Arabic and to evaluate its content validity, internal consistency, construct valid

Physical activity spectrum discriminant analysis—A method to compare detailed patterns between groups

Investigating physical activity (PA) patterns as a detailed intensity spectrum instead of crude intensity categories have improved the ability to analyze the relationship between measured PA and health variables. The aim of this methodological study was to introduce and investigate the utility of using detailed PA intensity spectrum compared to crude PA intensity categories for comparison of PA be

Plasma calprotectin in the emergency department : a potential clinical biomarker for patients with infectious diseases

Increased levels of plasma calprotectin are reported in patients with infectious diseases. However, the clinical usefulness of calprotectin as a biomarker to identify patients with infectious diseases in the emergency department (ED) setting has not been investigated. To study the ability of calprotectin to discriminate patients with acute infectious diseases and dyspnea from patients with other c

Distribution of cystatin C (gamma-trace), an inhibitor of lysosomal cysteine proteinases, in the anterior lobe of simian and human pituitary glands

Cystatin C, a protein inhibitor of lysosomal cysteine proteinases, was demonstrated by immunohistochemical techniques to be present in most luteinizing hormone- (LH-)containing cells in simian and human adenohypophyses. Immunoreactivity of cystatin C was also found in simian adrenocorticotrophic hormone- (ACTH-)containing cells localized to an area corresponding to the pars intermedia but not in t

Ensemble of Deep Convolutional Neural Networks with Monte Carlo Dropout Sampling for Automated Image Segmentation Quality Control and Robust Deep Learning Using Small Datasets

Recent progress on deep learning (DL)-based medical image segmentation can enable fast extraction of clinical parameters for efficient clinical workflows. However, current DL methods can still fail and require manual visual inspection of outputs, which is time-consuming and diminishes the advantages of automation. For clinical applications, it is essential to develop DL approaches that can not onl

Persistent current noise in narrow Josephson junctions

Josephson junctions have broad applications in metrology, quantum information processing, and remote sensing. For these applications, the electronic noise is a limiting factor. In this work we study the thermal noise in narrow Josephson junctions using a tight-binding Hamiltonian. For a junction longer than the superconducting coherence length, several self-consistent gap profiles appear close to