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Although CD4(+) memory T cells reside within secondary lymphoid tissue, the major reservoir of these cells is in the lamina propria of the intestine. In this study, we demonstrate that, in the absence of signals through both OX40 and CD30, CD4(+) T cells are comprehensively depleted from the lamina propria. Deficiency in either CD30 or OX40 alone reduced CD4(+) T cell numbers, however, in mice def
Background. Whole blood viscoelastic tests such as the fibrin-based thromboelastometry (ROTEM (R)) test FIBTEM are increasingly used in the perioperative setting to quickly identify deficits in fibrin quality, and to guide hemostatic therapy. The recently developed FibScreen2 test of the ReoRox (R) method, based on free oscillation rheometry, also provides an evaluation of fibrin clot quality. To
Retinal dystrophies (RD) constitute a group of blinding diseases that are characterized by clinical variability and pronounced genetic heterogeneity. The different nonsyndromic and syndromic forms of RD can be attributed to mutations in more than 200 genes. Consequently, next generation sequencing (NGS) technologies are among the most promising approaches to identify mutations in RD. We screened a
Energy-saving glass is becoming very popular in building design due to their effective shielding of building interior against heat entering the building with infrared (IR) waves. This is obtained by depositing a thin layer of metallic-oxide on the glass surface using special sputtering processes. This layer attenuates IR waves and hence keeps buildings cooler in summer and warmer in winter. Howeve
Objective and methods: Time-use methodologies have been proposed to be established research techniques when exploring aspects of daily occupations. In this study, two graphs illustrating the time arrangement of occupations as they appear in a continuous sequence were used in order to encourage individuals to reflect on their everyday life. The aim was to investigate the usefulness of a time-geogra
In a recent phylogenetic analysis of the family Teloschistaceae based on three molecular markers, 31 genera were newly described or resurrected. One of these genera was Parvoplaca, currently including four species in which anthraquinones may be present or absent in the apothecia. We have re-analyzed the genus and propose one new species, P. nigroblastidiata Arup, Halc & Vondrak, and one new co
Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new therapies are needed. We found that casein kinase 1 alpha (Csnk1a1), a serine-threonine kinase, is essential for AML cell survival in vivo. Normal hematopoietic stem and progenitor cells (HSPCs) were relatively less affected by shRNA-mediated knockdown of Csnk1
P-wave morphology reflects the projection of the depolarization vector on the electrocardiogram (ECG)lead axes in three-dimentional space and reflects both right and left atrial activation. The main purpose of current thesis was to explore the internal logic between the atrial conduction properties, including intra- and inter- atrial conduction, and P-wave characteristics from the level of histolo
To compare the cancer risk of cladribine and other disease-modifying drugs (DMDs) in trials of people with relapsing multiple sclerosis (pwRMS).
Two searches for supersymmetric particles in final states containing a same-flavour opposite-sign lepton pair, jets and large missing transverse momentum are presented. The proton-proton collision data used in these searches were collected at a centre-of-mass energy root s = 8TeV by the ATLAS detector at the Large Hadron Collider and corresponds to an integrated luminosity of 20.3 fb(-1). Two lept
We demonstrate experimentally and numerically that an x-ray prism made of beryllium can be used to disperse and monochromatize x-rays. A polished beryllium cuboid was employed as refractive and dispersive optics. The results of a proof-of-principle experiment and methods of performance optimization are presented. The spatial separation of undulator harmonics and their subsequent selection using a
Background: Marsupial syndactyly is a curious morphology of the foot found in all species of diprotodontian and peramelemorph marsupials. It is traditionally defined as a condition in which digits II and III of the foot are bound by skin and are reduced. Past treatments of marsupial syndactyly have not considered the implications of this unique morphology for broader issues of digit development an
This review summarises the evidence for the treatment of displaced fractures of the femoral neck in elderly patients. Results from randomised clinical trials and national register studies are presented when available. The advantages of arthroplasty compared with internal fixation are supported by several studies. A number of studies contribute to the discussions of total hip arthroplasty (THA) ver
Background. In SBRT of lung tumours no established relationship between dose-volume parameters and the incidence of lung toxicity is found. The aim of this study is to compare the LQ model and the universal survival curve (USC) to calculate biologically equivalent doses in SBRT to see if this will improve knowledge on this relationship. Material and methods. Toxicity data on radiation pneumonitis
The Soil Conservation Service Curve Number (SCS-CN) method developed by the USDA-Soil Conservation Service (SCS, 1972) is widely used for the estimation of direct runoff for a given rainfall event from small agricultural watersheds. The initial soil moisture plays an important role in re-structuring of the SCS-CN method and enables us to prevent unreasonable sudden jump in runoff estimation and th
Context. High-precision astrometric and radial-velocity observations require accurate modelling of stellar motions in order to extrapolate measurements over long time intervals, and to detect deviations from uniform motion caused, for example, by unseen companions. Aims. We aim to explore the simplest possible kinematic model of stellar motions, namely that of uniform rectilinear motion relative t
Heat transfer and flow characteristics of six ribbed channels of square cross section having different rib structure are computed with the objective of improving heat transfer in the lee-side of the ribs. Six ribs are installed on the bottom walls of each channel. The rib pitch-to-height ratio (P/e) is 10. Details of the turbulent flow structure, temperature fields, local heat transfer coefficient
We present the findings of our phenomenological interview study concerning the meaning of being an autonomous person while dependent on advanced medical technology at home. This was elucidated in the participants' narratives as befriending everyday life when bringing technology into the private sphere. We discovered four constituents of the phenomenon: befriending the lived body, depending on good
