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Cervical cancer among Swedish women with drug use disorders : A nationwide epidemiological study

Background/Aim: Cervical cancer incidence and mortality has decreased after introduction of national screening in Sweden, but women with drug use disorders (DUD) are less likely to participate in screening programs. We aimed to investigate cervical cancer incidence and mortality among women with DUD compared to the general female population in Sweden. Methods: We conducted a cohort study based on

Implementing the urban food–water–energy nexus through urban laboratories : a systematic literature review

The sustainability of complex resource systems, such as the food, water, and energy (FWE) nexus, is increasingly threatened by climate change impacts, expanding populations, urbanization, and economic instability. However, while research on the topic has burgeoned, studies focused on solution development and implementation, especially at the urban level, have lagged behind. Against this background

Pleiotropic anticoagulant functions of protein S, consequences for the clinical laboratory. Communication from the SSC of the ISTH

Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter-individual variability makes it problematic to establish reliable cut-off values. PS has multiple physiological functions, with only two appearing to have significant anticoagulant properties: the acti

Pathological insight into 5-ht2b receptor activation in fibrosing interstitial lung diseases

Interstitial lung disease (ILD) encompasses a heterogeneous group of more than 200 con-ditions, of which primarily idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia, hypersensitivity pneumonitis, ILD associated with autoimmune diseases and sarcoidosis may present a progressive fibrosing (PF) phenotype. Despite different aetiology and histopathological patterns, the

Acoustic cell patterning in hydrogel for three-dimensional cell network formation

In the field of engineered organ and drug development, three-dimensional network-structured tissue has been a long-sought goal. This paper presents a direct hydrogel extrusion process exposed to an ultrasound standing wave that aligns fibroblast cells to form a network structure. The frequency-shifted (2 MHz to 4 MHz) ultrasound actuation of a 400-micrometer square-shaped glass capillary that was

Heritagelore and an Introduction to the Thematic Issue on Culture and Heritage Under Construction

Taking inspiration in Barbro Klein’s work, this article focuses on the production of a particular type of institutional lore that we call heritagelore. Heritagelore, as we are advancing the concept here, is composed of the discursive practices within the walls and the organizations of museums. It is the lore that shapes and at least partially structures the types of stories that directors, museum

INTERnational Project for the Evaluation of "activE Rehabilitation" (inter-PEER) - A protocol for a prospective cohort study of community peer-based training programmes for people with spinal cord injury

Background: Active Rehabilitation (AR) is a community peer-based concept for people with spinal cord injury (SCI) that is primarily delivered through brief residential training programmes. Despite a plethora of positive anecdotal evidence of AR programmes as life-changing experiences, the effects of AR-programmes have not been evaluated scientifically. Here, we present the protocol of the INTERnat

In-situ chemical polymerization of Cu-Polythiophenes composite film as seed layer for direct electroplating on insulating substrate

Metal particles are embedded in the polymer to form a polymer composite film as a seed layer on an insulating substrate to overcome the limitation that electrodeposited copper only occurring at the interface between the polymer and the metal electrode. In this work, we successfully developed a Cu-polythiophenes composite film (Cu-PT composite film) through a facile in-situ reduction method, obtain

Interleukin-1 beta neutralization attenuates traumatic brain injury-induced microglia activation and neuronal changes in the globus pallidus

Traumatic brain injury (TBI) increases the risk of delayed neurodegenerative processes, including Parkinson’s disease (PD). Interleukin-1beta (IL-1β), a key pro-inflammatory cytokine, may promote secondary injury development after TBI. Conversely, neutralizing IL-1β was found to improve functional recovery following experimental TBI. However, the mechanisms underlying the behavioral improvements o

Homosocial stewardship : The opposed and unpaid care work of women water stewards in West Virginia, USA

The identity of people living in Central Appalachia is tightly connected with water. Because of the threats to water resources due to coal mining, and most recently, hydraulic fracturing and oil and gas pipeline projects, citizens have formed several nonprofit organizations to preserve or restore rivers and watersheds. Notably, women head the biggest, state-wide, most active and visible of these o

Clinical phenotype and course of PDE6A-associated retinitis pigmentosa disease, characterized in preparation for a gene supplementation trial

IMPORTANCE Treatment trials require sound knowledge on the natural course of disease. OBJECTIVE To assess clinical features, genetic findings, and genotype-phenotype correlations in patients with retinitis pigmentosa (RP) associated with biallelic sequence variations in the PDE6A gene in preparation for a gene supplementation trial. DESIGN, SETTING, AND PARTICIPANTS This prospective, longitudinal,

Rapid filamentary accretion as the origin of extended thin discs

Galactic outflows driven by stellar feedback are crucial for explaining the inefficiency of star formation in galaxies. Although strong feedback can promote the formation of galactic discs by limiting star formation at early times and removing low angular momentum (AM) gas, it is not understood how the same feedback can result in diverse objects such as elliptical galaxies or razor thin spiral gal

Democracy and human development : issues of conceptualization and measurement

This study attempts to reconcile competing positions in an important debate about the relationship between regime type and human development. We contend that this empirical relationship is contingent upon issues of conceptualization and measurement in democracy. First, the relationship is more likely to be perceived when democracy is measured in a nuanced fashion, taking account of gradations of d

Non-line-of-sight based radio localization with dual-polarization antenna arrays

This work presents an approach for radio-based localization in non-line-of-sight (NLOS) environments by leveraging a dual-polarization antenna array. By estimating the polarization of the received signal, it is possible to estimate the angle of reflection of a NLOS signal. An estimate of the position of the transmitter concerning the receiver can be obtained based on a joint estimation of the refl