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Method Development for PKM2 Activity Analysis in Cancer-Associated Signaling Pathways

Introduction: PARP14 belongs to the superfamily of PARPs that perform ADP-ribosylation of target proteins. The enzyme is involved in many cellular processes, including regulation of glycolysis, protein degradation, and genomic reparation. Background: PKM2 has been shown to be regulated indirectly by PARP14 to promote the Warburg effect. This describes an alternative glycolysis that cancer cells a

Attityder till ADHD i socialt arbete: en kvalitativ analys

This study focuses on attitudes towards ADHD in social work amongst social workers diagnosed with ADHD, their managers, and their colleagues. The study consists of six semi-structured interviews, done mostly over video calls. Two of the participants are social workers diagnosed with ADHD and four of the participants are managers who have co-workers that have been diagnosed with ADHD. The result ha

Motstridigheter i handlingsutrymmet - Yrkesverksamma socialarbetares upplevelser i arbetet med papperslösa klienter

This study aims to gain knowledge about social workers' experience of their work with undocumented clients and their perception of their room of action about their experiences with this client group. The study is of qualitative orientation and it’s been carried out through semi-structured interviews. The interviews were carried out with five social workers in different workplaces including non

Design and synthesis of 1,3-functionalized 2-propanol derivatives towards small blood-brain barrier permeable galectin-3 inhibitors

De senaste 50 åren har antalet äldre i det svenska samhället mer än fördubblats. Trenden är densamma runtom i världen - människor lever generellt längre nu än förr. Samtidigt som vi får glädjas över att få spendera mer tid med våra älskade innebär denna högre ålder samtidigt en ökad risk för vissa sjukdomar. En av dessa åldersrelaterade sjukdomar är demens, vilket idag ca 140 000 personer i SverigIn 2022, approximately 32 million patients worldwide suffered from Alzheimer’s disease dementia. In addition to this, about 380 million people carried the biomarkers indicating Alzheimer’s, while displaying little to no symptoms. These people, however, always live with the risk of the disease progressing - making the development of a drug that can slow down or stop progression an endeavour of glob

Kyrkan som "försvann"

I ett av världens mest sekulariserade länder, Sverige, har kyrkans historia och närvaro lämnat tydliga spår i våra städer och på vår landsbygd. Det kollektiva samhället och den kyrkliga gemenskapen har i stor utsträckning ersatts av individualism, vilket har bidragit till att förändra kyrkans roll och funktion. Kyrkan, och dess förutsättningar att bedriva verksamhet, står idag inför vissa utmaning

"Jag skulle bara vilja ta med dig hem och bara ta hand om dig" - En kvalitativ studie om känslomässiga utmaningar och hanteringsstrategier på kvinnojourer i Sverige

There are numerous women’s shelters in Sweden that offer protection and support to female victims of domestic violence. The purpose of this study was to investigate the emotional challenges faced by professionals working in these shelters, which may affect their performance and well-being. The study aimed to identify methods of promoting effective professional work and preventing emotional burnout

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This thesis begins by briefly discussing translation in general, identifying some of the problems involved in the linguistic activity. Then it seeks to explain what is involved in translation relating to film and television, i.e. subtitling. Finally, a comparison will be made between the Spanish speech in the Mexican film, Como agua para chocolate - directed by Alfonso Arau in 1992 and based on hi

Incestens påverkan på kvinnors relationer och självkänsla

Incest against children is a widespread social problem as it causes extensive psychological and physical harm to the child. Previous research has shown that the most harmful form of incest is the one that occurs between fathers and daughters. Therefore, this study aimed to investigate women's experiences of being subjected to incest and how it has affected their relationships and self-esteem.

Probing very close to antennas for manufacturing defect detection in a miniature shielded enclosure

This thesis investigates probing antennas within a small shielded test enclosure for IoT, Internet of Things, products for the detection of manufacturing deviations. The small enclosure forces the transmitter and receiver to be in the near-field. Shielding of the enclosure additionally generates a multipath environment, which becomes sensitive to displacements of objects such as wires or metallic

"Normer och diskurser i musikens värld" – En diskursanalys om hur populärmusik speglar och formar normer kring genus och sexuellt samtycke

This study examines how popular music reflects and shapes norms surrounding sexual consent through a discourse analysis of song lyrics from the Swedish Top 100 list of 2023. The research aims to critically analyze depictions of sexual interactions and consent in music, focusing on how these portrayals influence cultural perceptions of consent and gender roles. The methodology involves a qualitativ

Network as Sensor

The thesis introduces a concept of leveraging advanced 5G, or even future 6G networks, as powerful sensing systems. By utilizing communication network infrastructure, it explores the potential of deploying transmitter and receiver nodes at different locations, thus enabling the detection of Non-Line-of-Sight (NLOS), passive, dynamic objects transforming the network into dual-purpose communication

How Attitudes Towards People Shape Our Memories

This study investigated whether the emotional attitudes a person experiences toward another individual influence episodic memory for items associated with that individual. To examine this, we measured recognition memory for word pairs that had been previously presented overlaid on images of celebrities, with multiple images per celebrity. The participants were afterwards asked to report experience

In Search of the Monolayer - Utilizing Deep Learning to efficiently locate the Monolayer on Peripheral Blood Films

A Peripheral Blood Film (PBF) examination with differential count (DIFF) is a common blood test, yielding quantitative and qualitative information about the blood cells of the patient important for diagnostics. The test relies on locating the monolayer, an area on the PBF slide where the cells are located in one layer. This masters thesis explores the possibilities of adopting Machine Learning (ML

People-centred urban transformations with focus on the circadian potential of daylight in dense urban environments

This study used the urban context of Brunnshög, Sweden as a real case study to assess non-visual daylight conditions in urban environments. More precisely, the work was focusing on how the light spectrum – through surrounding façade colour and window type – can have an impact on the circadian potential. A one-bedroom apartment opening onto a courtyard on the ground floor and the same apartment on

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This dissertation will analyse three books. They are, in chronological order, La Colmena, by Camilio José Cela (1951), Historias de Kronen, by José Ángel Mañas (1994), and Amor, curiosidad, prozac, y dudas, by Lucía Etxebarría (1997). Etxebarría's book will be discussed before Mañas', since there are so many parallels between Amor... and La Colmena. Even though more than 40 years have pass