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Baseline Prostate-specific Antigen Level in Midlife and Aggressive Prostate Cancer in Black Men

Background: Prostate-specific antigen (PSA) measurement in midlife predicts long-term prostate cancer (PCa) mortality among white men. Objective: To determine whether baseline PSA level during midlife predicts risk of aggressive PCa in black men. Design, setting, and participants: Nested case-control study among black men in the Southern Community Cohort Study recruited between 2002 and 2009. A pr

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Cardiac arrest is rarely seen in children and teenagers. We present a 12-year old girl with cardiac arrest following myocardial infarction, that required prolonged cardiac massage and extracorporeal-membranous-oxygenation (ECMO). At coronary angiography the left main coronary artery (LMCA) was stented for a suspected coronary dissection. The contraction of the heart improved and the ECMO-treatment

Recycling of MSWI-bottom ash in paved constructions in Sweden – A risk assessment

This paper presents results from a risk assessment of recycling pre-treated bottom ash from municipal solid waste incineration as a subbase layer in certain asphalt paved constructions in Sweden. Based on a model for assessing environmental and health risks at contaminated areas, previously developed by the Swedish EPA and by the Swedish Geotechnical Institute, target values for total content and

Medicinsk etik i fokus

Vem avgör vad som är etiskt rätt att göra inom medicin och forskning? Och hur angriper en medicinetiker ett etiskt dilemma? I det här avsnittet möter vi Nils-Eric Sahlin, professor i medicinsk etik vid Lunds universitet och medlem i Statens medicinetiska råd (SMER). Vi pratar bland annat om artificiell intelligens i vården, hur de medicinetiska frågorna sett ut genom historien – och varför majorit

Improved cytogenetic characterization and risk stratification of pediatric acute lymphoblastic leukemia using single nucleotide polymorphism array analysis : A single center experience of 296 cases

Single nucleotide polymorphism array (SNP-A) analyses are increasingly being introduced in routine genetic diagnostics of acute lymphoblastic leukemia (ALL). Despite this, only few studies that have compared the diagnostic value of SNP-A with conventional chromosome banding have been published. We here report such a comparison of 296 ALL cases, the largest series to date. Only genomic imbalances >

Melatonin receptor 1B gene rs10830963 polymorphism, depressive symptoms and glycaemic traits

Background: The association between depression and type 2 diabetes is bidirectional. Underlying biological determinants remain elusive. We examined whether a common melatonin receptor 1B gene diabetes risk variant rs10830963 influenced the associations between depressive symptoms and glycaemic traits. Materials: The Prevalence, Prediction and Prevention of Diabetes-Botnia Study participants (n = 4

Nonstoichiometric triazolium protic ionic liquids for all-organic batteries

Non stoichiometric protic ionic liquids (NSPILs) are efficient electrolytes for protic electrochemical devices such as the all-organic proton battery, which has been suggested as a sustainable approach to energy storage. NSPILs contain a mixture of proton donors and acceptors and are ideal for this purpose due to their high proton conductivity, high electrochemical stability, low cost and ease of

Disappearing Investment-Cash Flow Sensitivities: Earnings Have Not Become a Worse Proxy for Cash Flow

According to a recent conjecture in the literature, earnings have become a poorer proxy for cash flow from operations over time. We find that since 1988, when cash flow statements started to be consistently reported in Compustat, the cash effectiveness of earnings has actually increased for a large sample of US manufacturing firms. This occurs despite the introduction of fair value accounting and According to a recent conjecture in the literature, earnings have become a poorer proxy for cash flow from operations over time. We find that since 1988, when cash flow statements started to be consistently reported in Compustat, the cash effectiveness of earnings has actually increased for a large sample of US manufacturing firms. This occurs despite the introduction of fair value accounting and

EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations

A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time–activity curve derived

Prevalence and Clinical Relevance of Extracardiac Findings in Cardiovascular Magnetic Resonance Imaging

Purpose: To assess the prevalence of extracardiac findings (ECF) during cardiovascular magnetic resonance (CMR) examinations and their downstream effect on clinical management. Materials and Methods: We retrospectively identified 500 consecutive patients. Trans-axial balanced steady-state free precession nongated images acquired from the upper thorax to the upper abdomen were evaluated independent

Missbruk av heroin och andra opioider

Denna bok bygger på aktuell forskning om opioidmissbruk i dess olika former och om lösningar för personer som fastnat i ett opioidmissbruk. Utifrån forskningen besvarar vi frågor som: Varför börjar unga människor använda dessa preparat? Varför är det så svårt att sluta när man har blivit beroende av opioider? Hur ser framgångsrik behandling ut?Under de senaste tjugo åren har olika opioidpreparat s

Cognitive deficits and psychopathological symptoms among children with medulloblastoma

Children with medulloblastoma (MB) are predisposed for negative cognitive sequela, which has been widely identified in this population. The purpose of the present study was to explore cognitive deficits and psychopathological symptoms and analyse their relation among MB survivors. The Wechsler Intelligence Scale for Children and the Mini International Neuropsychiatric Interview (MINI-KID) was admi

Ischemic QRS prolongation as a predictor of ventricular fibrillation in a canine model

Objectives. An acute coronary occlusion and its possible subsequent complications is one of the most common causes of death. One such complication is ventricular fibrillation (VF) due to myocardial ischemia. The severity of ischemia is related to the amount of coronary arterial collateral flow. In dog studies collateral flow has also been shown to be associated with QRS prolongation. The aim of th

LED and Life Cycles : Life Cycle Environmental Concerns in Procurement of LED Light

The development of LED light has been rapid in the last decade and it has become the most attractive lighting solution for many buyers. The reasons have to do with the high energy efficiency of these lamps as compared to the traditional incandescent lamps. As society is trying to cope with climate change threats and all the connected issues related to nature and life of people, all opportunities t

LED och livscykler : Livscykelbaserade miljöhänsyn vid inköp av LED-ljus

LED-ljusen har utvecklats i snabb takt under de senaste tio åren och de är idag de ljus som är mest attraktiva för många köpare. Det som gör dem så attraktiva är främst deras höga energieffektivitet jämfört med traditionella glödlampor. I linje med hur vi försöker handskas med klimatförändringarna och alla de hotbilder för människor och natur som denna utveckling förknippas med, så behöver vi ta t