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Mobility and earnings in an urban labor market: Gothenburg 1915-1943
Floskelvärdet av värdegrundsarbete är ofta högt
Hawking Radiation (e98, 2016)
Forty-two years ago, Stephen Hawking made predictions that radiation does escape from black holes. Known as “Hawking radiation” this phenomenon is too weak to observe with current techniques, and remained the “Holy Grail” for astrophysics. It has remained as such until recently when researchers led by Professor Steinhauer at the Israel Institute of Technology observed radiation emanating from an a
Historien bakom von Trapps flykt
En bakgrundsskildring av Österrike på 1930-talet, i form av ett förord till programbladet till Stockholms stadsteaters uppförande av The Sound of Music (hösten 2021).
High levels of autoantibodies against apoB100 p210 are associated with lower incidence of atrial fibrillation in women
BACKGROUND AND OBJECTIVES: Atrial fibrillation (AF) is associated with inflammation systemically and in the atrial tissue. Oxidized low-density lipoprotein (LDL) is increased in patients with AF and is suggested to be one of the molecules that drives inflammation. Autoantibodies against oxidized LDL and apolipoprotein B100, the protein component of LDL, are linked to atherosclerotic disease. Howev
Autoantibodies against methylglyoxal-modified apolipoprotein B100 and apob100 peptide are associated with less coronary artery atherosclerosis and retinopathy in long-term type 1 diabetes
OBJECTIVE Methylglyoxal (MGO), a reactive aldehyde forming advanced glycation end products (AGEs), is increased in diabetes and recognized by the immune system, resulting in anti-AGE-specific autoantibodies. The association of these immune responses with macro- and microvascular complications in type 1 diabetes remains unclarified. We investigated associations between MGO-modified apolipoprotein B
Studies on Transverse Resonance Island Buckets in third and fourth generation synchrotron light sources
A Transverse Resonance Island Bucket optics has a betatron tune close to a resonance, such that the particle motion is governed by non-linear terms in the equation of motion. This results in additional stable fixed points in transverse phase-space, which can be populated with a single RF-bunch filling pattern. Thus, these optics have the potential of providing pseudo single-bunch operation, i.e. a
Rapid extraction of short-lived isotopes from a buffer gas cell for use in gas-phase chemistry experiments, Part II : On-line studies with short-lived accelerator-produced radionuclides
A novel combination of advanced gas-chromatography and detection systems coupled to a buffer-gas cell was characterized on-line to allow gas-phase chemical studies of accelerator-produced short-lived α-decaying mercury, francium, and astatine isotopes. These were produced in 40Ar- and 48Ca-induced nuclear fusion–evaporation reactions, subsequently isolated in the recoil separators MARS at Texas A&
Early-stage symptomatic osteoarthritis of the knee — time for action
Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of disease and no available disease-modifying treatments. Symptomatic early-stage OA of the knee (the focus of this Review) urgently needs to be identified and defined, as efficient early-stage case finding and diagnosis in primary care would enable health-care providers to proactively and substantially reduce
The Long-Term Effects of Forced Migration : An Early-Life Approach with Evidence from Yugoslavian Refugees in Sweden
This paper analyzes the effect of being exposed to forced migration during childhood (ages 0-5) on educational achievement at age 15 (grade 9). Using register data from the Swedish Interdisciplinary Panel, I identify children who migrated to Sweden as a consequence of the rising conflict during the disintegration of the former Yugoslavia, and follow them until age 15, when they received their grades
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold : SAR of the Biphenyl Moiety
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compound 1, a potent hDHODH inhibitor (IC50 = 1.2 nM), able to induce myeloid differentiation in AML cell lines (THP1) in the low nM range (EC50 = 32.8 nM)
On the Use of Interaction Entropy and Related Methods to Estimate Binding Entropies
Molecular mechanics combined with Poisson-Boltzmann or generalized Born and solvent-accessible area solvation energies (MM/PBSA and MM/GBSA) are popular methods to estimate the free energy for the binding of small molecules to biomacromolecules. However, the estimation of the entropy has been problematic and time-consuming. Traditionally, normal-mode analysis has been used to estimate the entropy,
Zero-Dimensional Hybrid Organic-Inorganic Indium Bromide with Blue Emission
Low-dimensional hybrid organic-inorganic metal halides have received increased attention because of their outstanding optical and electronic properties. However, the most studied hybrid compounds contain lead and have long-term stability issues, which must be addressed for their use in practical applications. Here, we report a new zero-dimensional hybrid organic-inorganic halide, RInBr4, featuring
Simple plant and microbial exudates destabilize mineral-Associated organic matter via multiple pathways
Most mineral-Associated organic matter (MAOM) is protected against microbial attack, thereby contributing to longterm carbon storage in soils. However, the extent to which reactive compounds released by plants and microbes may destabilize MAOM and so enhance microbial access, as well as the underlying mechanisms, remain unclear. Here, we tested the ability of functionally distinct model exudates-l
Structure and laminar flame speed of an ammonia/methane/air premixed flame under varying pressure and equivalence ratio
This paper presents a joint experimental and numerical study on premixed laminar ammonia/methane/air flames, aiming to characterize the flame structures and NO formation and determine the laminar flame speed under different pressure, equivalence ratio, and ammonia fraction in the fuel. The experiments were carried out in a lab-scale pressurized vessel with a Bunsen burner installed with a concentr
Online-2D NanoLC-MS for Crude Serum Proteome Profiling : Assessing Sample Preparation Impact on Proteome Composition
Although current LC-MS technology permits scientists to efficiently screen clinical samples in translational research, e.g., steroids, biogenic amines, and even plasma or serum proteomes, in a daily routine, maintaining the balance between throughput and analytical depth is still a limiting factor. A typical approach to enhance the proteome depth is employing offline two-dimensional (2D) fractiona
Despite reductions in muscle mass and muscle strength in adults with CHD, the muscle strength per muscle mass relationship does not differ from controls
Background: Patients with CHD exhibit reduced isometric muscle strength and muscle mass; however, little is known how these parameters relate. Therefore, the aim was to investigate the relation between isometric limb muscle strength and muscle mass for patients in comparison to age- and sex-matched control subjects. Methods: Seventy-four patients (35.6 ± 14.3 years, women n = 22) and 74 matched co
Three new species of crustose Teloschistaceae in Siberia and the Far East
Three species of the family Teloschistaceae (lichenized Ascomycota) are described as new to science from Southern and Eastern Siberia and the Far East. Corticolous Caloplaca saviczii belongs to the genus Caloplaca s. str.; it has C. cerina-like apothecia and green to grey-green, crateriform soralia with a white rim. Lendemeriella aureopruinosa is a saxicolous taxon with a thin grey thallus and sma
Batch processing of tree-ring samples for radiocarbon analysis
We here present a comparison of methods for the pretreatment of a batch of tree rings for high-precision measurement of radiocarbon at the Aarhus AMS Centre (AARAMS), Aarhus University, Denmark. The aim was to develop an efficient and high-Throughput method able to pretreat ca. 50 samples at a time. We tested two methods for extracting α-cellulose from wood to find the most optimal for our use. On