Background: Proteolytic degradation of amyloid β (Aβ) peptides has been intensely studied due to the central role of Aβ in Alzheimer’s disease (AD) pathogenesis. While several enzymes have been shown to degrade Aβ peptides, the main pathway of Aβ degradation in vivo is unknown. Cerebrospinal fluid (CSF) Aβ42 is reduced in AD, reflecting aggregation and deposition in the brain, but low CSF Aβ42 is,

Purpose: The aim of this paper is to review the evidence of the association between energy balance and obesity. Methods: In December 2015, the International Agency for Research on Cancer (IARC), Lyon, France convened a Working Group of international experts to review the evidence regarding energy balance and obesity, with a focus on Low and Middle Income Countries (LMIC). Results: The global epide

Eutrophication is one of the most serious global threats to coastal areas. One effect of eutrophication is seasonal macroalgal blooms. As a consequence, large amounts of beach-cast algae are today reported from coastal areas worldwide. In this study, we analyze nonmarket benefits by capturing local residents' Willingness To Pay (WTP) for an environmental program to regularly remove and utilize beaEutrophication is one of the most serious global threats to coastal areas. One effect of eutrophication is seasonal macroalgal blooms. As a consequence, large amounts of beach-cast algae are today reported from coastal areas worldwide. In this study, we analyze nonmarket benefits by capturing local residents' Willingness To Pay (WTP) for an environmental program to regularly remove and utilize bea

Background and purpose — Patient-reported outcome measures (PROMs) are increasingly used to evaluate results in orthopedic surgery. To enhance good responsiveness with a PROM, the minimally important change (MIC) should be established. MIC reflects the smallest measured change in score that is perceived as being relevant by the patients. We assessed MIC for the Self-reported Foot and Ankle Score (

Purpose: A degenerative meniscus lesion is a slowly developing process typically involving a horizontal cleavage in a middle-aged or older person. When the knee is symptomatic, arthroscopic partial meniscectomy has been practised for a long time with many case series reporting improved patient outcomes. Since 2002, several randomised clinical trials demonstrated no additional benefit of arthroscop

Background: The schedule for affective disorders and schizophrenia for school-age children (K-SADS) is one of the most commonly used standardized diagnostic interviews in child and adolescent psychiatry. Validity studies are scarce, and limited to concurrent validity with other measures and clinical diagnoses. Aims: To evaluate the K-SADS interview in an outpatient child and adolescent psychiatry

Background and Purpose: Stroke is one of the dominant causes of death and adult disability in the world. There is a need for novel therapeutic approaches to improve functional recovery and outcome after stroke, and experimental studies have shown that stem cell-based therapies (SCT) hold much potential in this regard. This thesis, comprising 5 papers, aims to explore and describe clinical symptoms

Women tend to have competence doubts for masculine-stereotyped domains (e.g., math), whereas men tend to think they can handle both feminine-stereotyped and masculine-stereotyped domains equally well. We suggest that perhaps women's more frequent experience with stereotype threat can partly explain why. Our results showed that when stereotype threat was primed in high school students (n = 244), th

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Photodynamic therapy (PDT) using Photofrin IIR (PII) as a photosensitizer is currently being evaluated as a new treatment modality for superficial bladder cancer. An optimum therapeutic ratio requires uniform illumination of the whole bladder wall and accurate light dosimetry. The first clinical light dosimetry results (16 patients) are reported, obtained using a system which allows in situ measur

We give a sufficient condition for the Fourier dimension of a countable union of sets to equal the supremum of the Fourier dimensions of the sets in the union, and show by example that the Fourier dimension is not countably stable in general. A natural approach to finite stability of the Fourier dimension for sets would be to try to prove that the Fourier dimension for measures is finitely stable,

The aim of this study is to evaluate the existence of a possible relationship between global deuterium-labeled water (HDO) uptake rates and the diffusion geometry of human glioma xenografts in nude mice. HDO diffusion times in the whole extravascular tumor volume were estimated by combining quantitative (1)H-MR diffusion imaging and morphometric analysis of intercapillary distances in two tumor li