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Over the last decade, the family of galectin proteins has been identified as key regulators of important biological processes. They bind β-D-galactopyranoside residues in glycoconjugates, and by presenting multiple binding sites, within one galectin or by forming dimers or multimers, they can cross-link glycoproteins and form galectin-glycoprotein lattices. Such lattices formed on the cell surface
Automotive interior components are produced by injection moulding due to its cost effectiveness in mass production. The surfaces of these components are textured to control the appearance and other surface functional properties such as wear and scratch resistance. Key challenges lie in replicating the features of mould tool with high aspect ratio which are influenced by the polymer and large numbe
Purpose: To investigate the possibility to be able to offer left sided breast cancer patients, not suitable for DIBH, an organ at risk saving treatment. Materials and Methods: Twenty patients receiving radiotherapy for left breast cancer in DIBH were enrolled in the study. Planning CT scans were acquired in the same supine treatment position in FB and DIBH. 3DCRT_DIBH plans were designed and optim
Lignin is the second most abundant natural polymer after cellulose, and valorisation of lignin-rich streams has attracted increasing attention recently. This paper presents a novel and sustainable method to recover lignin from Cocoa Bean Shells (CBS) using Deep Eutectic Solvents (DES) and microwaves. A DES containing p-toluenesulfonic acid, choline chloride and glycerol (2:1:1 M ratio) was selecte
Second-hand consumption of clothing can support the transition to circular economies by prolonging the lifespan of products through reuse. Historically, not-for-profit businesses have been dominant actors in second-hand markets across Western Europe and North America. However, with the growing interest in second-hand consumption, for-profit firms have increasingly entered this market over the last
Soil microbial growth and activity are generally assumed to recover rapidly after dissipation of organic toxicants. We studied the effects of four readily degradable isothiazolinone biocides (benzisothiazolinone, BIT; methylisothiazolinone, MIT; octylisothiazolinone, OIT; 4,5-dichloro-2-octyl-isothiazolinone, DCOIT) on bacterial growth, fungal growth, basal respiration, and substrate-induced respi
Chinese culinary culture has a long history of development and has unique characteristics, attracting people from all over the world. As a world-renowned restaurant award, the Michelin Guide in China plays an influential role in introducing Chinese culinary culture to the world and destination branding, while few studies have investigated Michelin-starred restaurants (MSRs) in China. This study th
This paper investigates the evolution of inequality in China (1978–2015) through the lens of a dynamic spatial general equilibrium model with migration and capital formation. Due to an urban-rural income gap there is domestic migration from the rural to the urban areas which tends to reduce inequality. The resulting increase in urban house prices can, however, constitute an endogenous barrier to f
Magnetic fields play a key role in driving a broad range of dynamic phenomena in the atmospheres of the Sun and other stars. Routine and accurate measurements of the magnetic fields at all the atmospheric layers are of critical importance to understand these magnetic activities, but in the solar and stellar coronae such a measurement is still a challenge due to the weak field strength and the high
Chronic kidney disease of non-traditional origin (CKDnt) and acute kidney injury (AKI) often affect heat-stressed Mesoamerican manual workers. Inflammation occurs concurrently with AKI in this population, but its role remains unknown. To explore links between inflammation and kidney injury in heat stress, we compared levels of inflammation-related proteins in cutters with and without increasing se
Globally, biodiversity offsetting is used to balance negative impacts on biodiversity and ecosystem services caused by exploitation. In Sweden, there is an increasing interest in biodiversity offsetting in urban planning. However, there is limited understanding about the use of the concept in a municipal context. This study aims to examine and critically reflect on the uptake and use of biodiversi
Tissue clearing is commonly used for whole-brain imaging but seldom used for brain slices. Here, we present a simple protocol to slice, immunostain, and clear sections of adult rat brains for subsequent high-resolution confocal imaging. The protocol does not require toxic reagents or specialized equipment. We also provide instructions for culturing of rat brain slices free floating on permeable cu
SPATA2 mediates the recruitment of CYLD to immune receptor complexes by bridging the interaction of CYLD with the linear ubiquitylation assembly complex (LUBAC) component HOIP. Whether SPATA2 exhibits functions independently of CYLD is unclear. Here, we show that, while Cyld−/− and Spata2−/− mice are viable, double mutants exhibit highly penetrant perinatal lethality, indicating independent functi
Induced pluripotent stem cell (iPSC) reprogramming is inefficient and understanding the molecular mechanisms underlying this inefficiency holds the key to successfully control cellular identity. Here, we report 24 reprogramming roadblock genes identified by CRISPR/Cas9-mediated genome-wide knockout (KO) screening. Of these, depletion of the predicted KRAB zinc finger protein (KRAB-ZFP) Zfp266 stro
Introduction: Plasma-measured tau phosphorylated at threonine 217 (p-tau217) is a potential non-invasive biomarker of Alzheimer's disease (AD). We investigated whether plasma p-tau217 predicts subsequent cognition and positron emission tomography (PET) markers of pathology in autosomal dominant AD. Methods: We analyzed baseline levels of plasma p-tau217 and its associations with amyloid PET, tau P
Type 2 diabetes (T2D) is a polygenic disease and studies to understand the etiology of the disease have required selectively bred animal models with polygenic background. In this review, we present two models; the Goto-Kakizaki (GK) rat and the Oikawa-Nagao Diabetes-Prone (ON-DP) and Diabetes-Resistant (ON-DR) mouse. The GK rat was developed by continuous selective breeding for glucose tolerance f
This paper investigates the impact of public policies aimed to foster entrepreneurship on the national entrepreneurial culture of a country. While most of the existing studies focus on the direct impact of policies on entrepreneurship outcomes, we propose that the impact of policies on entrepreneurial culture may be even more important for the development of economies in the long term. Using data
Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue disease. Once considered an untreatable and unpredictable condition, research advancements have improved our understanding of its disease pathogenesis and clinical phenotypes and expanded our treatment armamentarium. Early and accurate diagnosis is essential, while ongoing efforts to risk stratify pat
Ultra-scaled ferroelectrics are desirable for high-density nonvolatile memories and neuromorphic computing; however, for advanced applications, single domain dynamics and defect behavior need to be understood at scaled geometries. Here, we demonstrate the integration of a ferroelectric gate stack on a heterostructure tunnel field-effect transistor (TFET) with subthermionic operation. On the basis
