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In a series of famous experiments, Benjamin Libet claimed to have shown that there is no scientific basis for our commonsensical understanding of freedom of the will. The actions we are about to undertake register in our brains before they register in our conscious minds. And yet, all that Libet may have shown is that long-invoked notions such as “the will” and “freedom” are poor explanations of h
Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes affect human islet function and if blood-based epigenetic biomarkers reflect these changes and associate with future T2D. We analyse DNA methylation genome-wide in islets from 87 non-diabetic donors, aged 26-74 years. Aging associates with increa
The canonical Wnt signaling can be silenced either through β-catenin-mediated ubiquitination and degradation or through phosphorylation of Tcf and Lef by nemo-like kinase (NLK). In the present study, we generated NLK deficient animals and found that these mice become cyanotic shortly before death because of lung maturation defects. NLK-/- lungs exhibited smaller and compressed alveoli and the mese
This paper explores the meaning and potential impact of a number of street artworks that in different ways address and problematise how human beings relate to the biotic community – that is to say a community founded on biocentrism that includes as its members “soils, waters, plants, and animals, or collectively: the land” (Leopold, 1949/1968, p. 203.).The paper argues that while, for example, inf
INTRODUCTION: Not only repolarization, but also depolarization ECG indexes reflect the progression of ischemic injury. The aim was to assess the QRS duration and morphology dynamics during the prolonged coronary occlusion and their association with the myocardial area at risk (MaR) and final infarct size (IS).METHODS: In pigs, myocardial infarction was induced by inflation of an angioplasty balloo
Huntington's Disease (HD) is an inherited neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. The YAC128 mouse model of HD expresses the full-length human huntingtin protein with 128 CAG repeats and replicates the phenotype and neurodegeneration that occur in HD. Several studies have implicated a role for neuroinflammation in HD pathogenesis. Studies on presymp
PURPOSE: Preoperative percutaneous transabdominal wall biopsy may be considered to diagnose gastrointestinal stromal tumour (GIST) and plan preoperative treatment with tyrosine kinase inhibitors when an endoscopic biopsy is not possible. Hypothetically, a transabdominal wall biopsy might lead to cell seeding and conversion of a local GIST to a disseminated one. We investigated the influence of pre
In this work, we analyze the use of a WiFi network deployed in a large-scale technical university. To this extent, we leverage three weeks of WiFi traffic data logs and characterize the spatio-temporal correlation of the traffic at different granularities (each individual access point, groups of access points, entire network). The spatial correlation of traffic across nearby access points is also
In the field of lighting and daylighting, standard monitoring procedures to assess the overall performance of retrofit projects are scarce. Nevertheless, access to monitored data is crucial in assessing whether daylighting or electric lighting systems deliver the expected performance in terms of cost-effectiveness, energy efficiency and lighting quality. In order to bridge this gap, a lighting ret
BACKGROUND: There is need for an updated systematic review of associations between occupational exposures and ischaemic heart disease (IHD), using the GRADE system.METHODS: Inclusion criteria: (i) publication in English in peer-reviewed journal between 1985 and 2014, (ii) quantified relationship between occupational exposure (psychosocial, organizational, physical and other ergonomic job factors)
The present thesis investigated Swedish nouns differing in concreteness, specificity and emotional content using linguistic, psycholinguistic and neurolinguistic methods. The focus of Paper I was a semantic analysis of discourse produced by a person with a lesion in visual (left occipital) cortex. The results showed that the lesion site was related to with problems processing concrete nouns relateThe present thesis investigated Swedish nouns differing in concreteness, specificity and emotional content using linguistic, psycholinguistic and neurolinguistic methods. The focus of Paper I was a semantic analysis of discourse produced by a person with a lesion in visual (left occipital) cortex. The results showed that the lesion site was related to with problems processing concrete nouns relate
The human restricted pathogen Moraxella catarrhalis is an important causal agent for exacerbations in chronic obstructive lung disease (COPD) in adults. In such patients, increased numbers of granulocytes are present in the airways, which correlate with bacteria-induced exacerbations and severity of the disease. Our study investigated whether the interaction of M. catarrhalis with the human granul
BACKGROUND: It has been suggested that osteoblasts are involved in the regulation of haematopoietic stem cells. Whether osteocalcin, which is derived from osteoblasts and is metabolically active, influences blood haemoglobin (Hb) levels is not known.OBJECTIVE: To determine whether plasma osteocalcin is a determinant of Hb in elderly men.METHODS: A total of 993 men (mean age 75.3 ± 3.2 years) parti
OBJECTIVE: On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies, and human clinical
This thesis deals with the development and application of new estimation approaches based on factor analysis for estimation and inference in dynamic panel data models with fixed-effects. A new factor analytical method (FA) for the estimation of fixed-effects dynamic panel data models is proposed in Bai ("Fixed-Effects Dynamic Panel Models, A Factor Analytical Method". Econometrica 81, 285-314, 201
This paper proposes a time-frequency (t-f) image enhancement method for suppressing interference terms in the Wigner-Ville distribution. The proposed technique adapts the direction of the smoothing kernel locally at each t-f point, so that the smoothing kernel remains aligned with the ridges of the auto-terms. This local alignment of the smoothing kernel reduces cross-terms without degrading the e
This study investigated effects of surfactant sodium dodecylbenzene sulfonate (SDBS) on flow boiling heat transfer of ethylene glycol/water mixtures in a vertical minitube. Experiments were performed using solutions containing 300 ppm by weight of surfactant and the results were compared with those of pure mixture. Local heat transfer coefficient was measured and found to be dependent on the mass
