Preclinical trials of cancer drugs in animal models are important for drug development. The Rip1Tag2 (RT2) transgenic mouse, a model of pancreatic neuroendocrine tumours (PNET), has provided immense knowledge about PNET biology, although tumour progression occurs in a location inaccessible for real-time monitoring. To overcome this hurdle we have developed a novel platform for intravital 3D imagin

Collective behaviour in suspensions of microswimmers is often dominated by the impact of long-ranged hydrodynamic interactions. These phenomena include active turbulence, where suspensions of pusher bacteria at sufficient densities exhibit large-scale, chaotic flows. To study this collective phenomenon, we use large-scale (up to N = 3 × 106) particle-resolved lattice Boltzmann simulations of model

Hox genes orchestrate development by patterning the embryonic axis. Vertebrate Hox genes are arranged in four compact clusters, and the spacing between genes is assumed to be crucial for their function. The genomes of squamate reptiles are unusually rich and variable in transposable elements (TEs), and it has been suggested that TE invasion is responsible for the Hox cluster expansion seen in snak

Developmental plasticity looks like a promising bridge between ecological and developmental perspectives on evolution. Yet, there is no consensus on whether plasticity is part of the explanation for adaptive evolution or an optional "add-on" to genes and natural selection. Here, we suggest that these differences in opinion are caused by differences in the simplifying assumptions, and particular id

Emotional labour has for decades been addressed and investigated in tourism studies andtourism management. Originally coined by Arlie Hochschild in the late 1970s it has increasinglybeen elaborated upon in relation to tourism service work. This take on the originally sociologicalconcept has predominatly been managerial in tourism management studies, and contextualized asa clear-cut social interact

Western society has increasingly turned to different kinds of spirituality in dealing with an accelerated tempo and demands in everyday post-modern life. Yoga, meditation, mindfulness and other forms of modalities, often connected to ancient eastern thinking, are taught and implemented in management and leadership practises (Cederström & Spicer, 2015). Although organizational theorizing has prWestern society has increasingly turned to different kinds of spirituality in dealing with an accelerated tempo and demands in everyday post-modern life. Yoga, meditation, mindfulness and other forms of modalities, often connected to ancient eastern thinking, are taught and implemented in management and leadership practises (Cederström & Spicer, 2015). Although organizational theorizing has pr

Spatial constituents of adult symbolic number representation produce effects of size-value congruity, Spatial Numerical Association of Response Codes (SNARC), and numerical distance. According to behavioral experiments, these effects belong to distinct processing stages. Yet, these effects evoke overlapping responses in both early and late Event Related Potentials (ERPs). To probe whether these ov

We investigated visual working memory encoding across saccadic eye movements, focusing our analysis on refixation behavior. Over 10-s periods, participants performed a visual search for three, four, or five targets and remembered their orientations for a subsequent change-detection task. In 50% of the trials, one of the targets had its orientation changed. From the visual search period, we scored

An unresolved problem in eye movement research is how a representation is constructed on-line from several consecutive fixations of a scene. Such a scene representation is generally understood to be sparse; yet, for meeting behavioral goals a certain level of detail is needed. We propose that this is achieved through the buildup of latent representations acquired at fixation. Latent representation

This study investigated the influence of target probability on the neural response to target detection in free viewing visual search. Participants were asked to indicate the number of targets (one or two) among distractors in a visual search task while EEG and eye movements were co-registered. Target probability was manipulated by varying the set size of the displays between 10, 22, and 30 items.

In free viewing, the eyes return to previously visited locations rather frequently, even though the attentional and memory-related processes controlling eye-movement show a strong antirefixation bias. To overcome this bias, a special refixation triggering mechanism may have to be recruited. We probed the neural evidence for such a mechanism by combining eye tracking with EEG recording. A distincti

While viewing a scene, the eyes are attracted to salient stimuli. We set out to identify the brain signals controlling this process. In a contour integration task, in which participants searched for a collinear contour in a field of randomly oriented Gabor elements, a previously established model was applied to calculate a visual saliency value for each fixation location. We studied brain activity

Transcranial alternating-current stimulation (tACS) for entraining alpha activity holds potential for influencing mental function, both in laboratory and clinical settings. While initial results of alpha entrainment are promising, questions remain regarding its translational potential-namely if tACS alpha entrainment is sufficiently robust to context and to what extent it can be upscaled to multi-

Shape perception is intrinsically holistic: combinations of features give rise to configurations with emergent properties that are different from the sum of the parts. The current study investigated neural markers of holistic shape representations learned by means of categorization training. We used the EEG frequency tagging technique, where two parts of a shape stimulus were 'tagged' by modifying

In spontaneous, stimulus-evoked, and eye-movement evoked EEG, the oscillatory signal shows large scale, dynamically organized patterns of phase. We investigated eye-movement evoked patterns in free-viewing conditions. Participants viewed photographs of natural scenes in anticipation of a memory test. From 200 ms intervals following saccades, we estimated the EEG phase gradient over the entire scal

In free visual exploration, eye-movement is immediately followed by dynamic reconfiguration of brain functional connectivity. We studied the task-dependency of this process in a combined visual search-change detection experiment. Participants viewed two (nearly) same displays in succession. First time they had to find and remember multiple targets among distractors, so the ongoing task involved me

Do we perceive a group of dancers moving in synchrony differently from a group of drones flying in-sync? The brain has dedicated networks for perception of coherent motion and interacting human bodies. However, it is unclear to what extent the underlying neural mechanisms overlap. Here we delineate these mechanisms by independently manipulating the degree of motion synchrony and the humanoid quali

Perceptual learning improves visual performance. Among the plausible mechanisms of learning, reduction of perceptual bias has been studied the least. Perceptual bias may compensate for lack of stimulus information, but excessive reliance on bias diminishes visual discriminability. We investigated the time course of bias in a perceptual grouping task and studied the associated cortical dynamics in

Co-registration of EEG and eye movement has promise for investigating perceptual processes in free viewing conditions, provided certain methodological challenges can be addressed. Most of these arise from the self-paced character of eye movements in free viewing conditions. Successive eye movements occur within short time intervals. Their evoked activity is likely to distort the EEG signal during