Non-convulsive status epilepticus (NCSE) is a prolonged epileptic seizure with subtle symptoms that may delay clinical diagnosis. Emerging experimental evidence shows brain pathology and epilepsy development following NCSE. New diagnostic/prognostic tools are therefore needed for earlier and better stratification of treatment. Here we examined whether NCSE initiates a peripheral immune response in

Background: Evidence-based recommendations are lacking for prosthetic and orthotic services in low- and lower-middle-income countries. Objectives: The aim of this study was to compare and synthesise findings related to experiences of prosthetic and orthotic service delivery in Tanzania, Malawi, Sierra Leone and Pakistan from the perspective of local professionals. Study design: This is a qualitati

Växtätare kan påverka ekosystemprocesser, dels genom långsiktiga förändringar av växtsamhällets sammansättning, men också på kortare sikt genom derasmatspjälkning av organiskt material som cyklas genom markens nedbryderorganismer och tillbaka till de primära producenterna. Särskilt störreväxtätare har studerats i stor utsträckning, men i vissa ekosystem som skogar kan de mindre ryggradslösa växtätHerbivory can influence ecosystem processes, partly through long-term changes of the plant community compositions, but also more rapidly through the herbivores’ digestive alteration of the organic matter that is cycled through the soil and back to the primary producers. In the Subarctic mountain birch (Betula pubescens ssp. czerepanovii) forest (SMBF) in Northern Fennoscandia, outbreaks by the geo

Nonstoichiometric protic ionic liquids have recently gained interest because proton acceptors are crucial in the electrolyte of many electrochemical applications such as fuel cells, proton batteries and supercapacitors. In the present work we have prepared and studied several protic poly(ionic liquid)s doped with acid in nonstoichiometric amounts. The poly(ionic liquid)s were based on polydimethyl

Gadolinium-based contrast agents (GBCAs) increase lesion detection and improve disease characterization for many cerebral pathologies investigated with MRI. These agents, introduced in the late 1980s, are in wide use today. However, some non-ionic linear GBCAs have been associated with the development of nephrogenic systemic fibrosis in patients with kidney failure. Gadolinium deposition has also

While migration has become an all-important topic of discussion around the globe, mainstream literature on migrants' legal adaptation and integration has focused on case studies of immigrant communities in Western-style democracies. We know relatively little about how migrants adapt to a new legal environment in the ever-growing hybrid political regimes that are neither clearly democratic nor conv

Nanostructure and mechanical properties of bulk nanocristalline cubic boron nitride have been studied by transmission electron microscopy and micro- and nanoindentation. The obtained data on hardness, elastic properties, and fracture toughness clearly indicate that nano-cubic (F 4 3 m) boron nitride belongs to a family of advanced ultrahard materials.

Beskrivning av framväxten av ekonomexamen, finansanalytiker som "profession" och finansialiseringen av Sverige

In 1975, Sweden extended voting rights in local elections toimmigrants without Swedish citizenship (resident aliens). In thisarticle, I show that the arguments behind the reform were based on a wish to speed up the integration of immigrants ratherthan normative ideas about the nature of democracy. The reform was in fact seen as part of the emerging Swedishintegration policy. Almost a decade later,

Background: Calcitonin gene-related peptide (CGRP) is a neuronal transmitter present in intracranial sensory nerves, where it is involved in migraine pathophysiology as well as other biological functions. Recently, the fully human monoclonal antibody erenumab (AMG 334), which targets the canonical calcitonin gene-related peptide receptor, showed significant prophylactic efficacy and favourable saf

This paper is devoted to studying the long-term behaviour of a continuous-time Markov chain that can be interpreted as a pair of linear birth processes which evolve with a competitive interaction; as a special case, they include the famous Lotka-Volterra interaction. Another example of our process is related to urn models with ball removal. We show that, with probability one, the process eventuall

Ledare: Det behövs alternativ till bilen som görs tillgängliga för så många som möjligt så att trafiken kan minska och klimatmålen uppnås. Det skriver Alfred Andersson i denna klimatkrönika. På torsdag den 19 september håller han en föreläsning om transporterna och klimatmålen på Stadsbiblioteket i Halmstad i serien Klimatet & vi som går under hösten.

A series of novel isochromanone based urotensin II receptor agonists have been synthesized and evaluated for their activity using a functional cell based assay (R-SAT). Several potent and efficacious derivatives were identified with 3-(3,4-dichlorophenyl)-6,7-dimethyl-3-(2-dimethylaminoethyl)isochroman-1-one (28) being the most potent compound showing an EC50-value of 51 nM, thereby being the most

We report the first small-molecule protease-activated receptor (PAR) 2 agonists, AC-55541 [N-[[1-(3-bromo-phenyl)-eth-(E)-ylidene-hydrazinocarbonyl]- (4-oxo-3,4-dihydro-phthalazin-1-yl)-methyl]-benzamide] and AC-264613 [2-oxo-4-phenylpyrrolidine-3-carboxylic acid [1-(3-bromo-phenyl)-(E/Z)- ethylidene]-hydrazide], each representing a distinct chemical series. AC-55541 and AC-264613 each activated P

To understand the contribution of the estrogen receptor beta, the potent and selective agonist ERb-131 was evaluated in animal models of inflammatory pain. In paradigms of acute and persistent inflammatory pain, ERb-131 did not alleviate the nociception induced by either carrageenan or formalin. However, in the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hypera

Export of warm and salty waters from the Caribbean to the North Atlantic is an essential component of the Atlantic Meridional Overturning Circulation (AMOC). However, there was also an active AMOC during the Miocene, despite evidence for an open Central American Seaway (CAS) that would have allowed low-salinity Pacific waters to enter the Caribbean. To address this apparent contradiction and to co

Antisera against a variety of substances have been found to produce an identical immunoreaction in the developing olfactory system of a teleost, the three-spined stickleback (Gasterosteus aculeatus). The label is localized in the olfactory placode, the olfactory nerve and those parts of the secondary olfactory tracts which constitute the dorsal descending fascicles and the ventral descending fiber