Background: Chronic prurigo (CPG) is a distinct disease characterized by chronic pruritus, history and/or signs of prolonged scratching and multiple pruriginous lesions. It may present with various clinical manifestations, including papules, nodules, plaques or umbilicated lesions. Some patients with chronic pruritus show pruriginous linear and scaring scratch lesions (LSSL) and it is unclear whet

Hox genes are a remarkable example of conservation in animal development and their nested expression along the head-to-tail axis orchestrates embryonic patterning. Early in vertebrate history, two duplications led to the emergence of four Hox clusters (A-D) and redundancy within paralog groups has been partially accommodated with gene losses. Here we conduct an inventory of squamate Hox genes usin

The incidence of stroke and dementia are diverging across the world, rising for those in low- and middle-income countries and falling in those in high-income countries. This suggests that whatever factors cause these trends are potentially modifiable. At the population level, neurological disorders as a group account for the largest proportion of disability-adjusted life years globally (10%). Amon

The number of publications in the field of chemical cross-linking combined with mass spectrometry (XL-MS) to derive constraints for protein three-dimensional structure modeling and to probe protein-protein interactions has increased during the last years. As the technique is now becoming routine for in vitro and in vivo applications in proteomics and structural biology there is a pressing need to

Carbon Fiber Reinforced Polymer (CFRP) has highly abrasive microstructure due to carbon fiber reinforcement and requires the use of tool materials with good resistance to abrasive wear. The paper presents a study of tool wear in drilling operation. Drill bits with uncoated and diamond coated cemented carbide and polycrystalline diamond were tested in drilling PAN-based CFRP samples. Registered thr

Widespread increases in iron (Fe) concentrations are contributing to ongoing browning of northern freshwaters, but the driver/s behind the trends are not known. Fe mobilization in soils is known to be controlled by redox conditions, pH, and DOC availability for complexation. Moreover, high sulfate concentrations have been suggested to constrain Fe in transition from soil to water, and declining su

Current trends in diffusion NMR and MRI methods development are reviewed. While great efforts are still directed towards further improving the spectral, spatial, and relaxation rate resolution of basic diffusion measurements, recent improvements in magnetic field gradient technology on whole-body scanners have enabled an exciting line of research involving MRI implementations of advanced diffusion

In a rapidly digitalizing world, the increasing importance of online information channels is repeatedly stated. But little is known about the procedure of online information search. This study examines the process of booking a journey via digital devices. It is based on a multi-method approach including interview and experiment. Results show that tourists’ online searching behaviour is less ration

In order to provide a reliable evacuation design assessment, data showing the variation in pre-movement time is of vital importance. The pre-movement time is in many cases regarded as the main time period during an evacuation assessment. Therefore, forty unannounced evacuation experiments for six different occupancies were analysed to quantify pre-movement time during building evacuation, i.e., th

The aim of this work is to develop a novel green solvent based sustainable process to refine lignin into low molecular weight (LMW) and high molecular weight (HMW) fractions. Lignin dispersity reduction were experimentally determined using four solvent mixtures, and benchmarked against eight pure solvents. Data outputs were used for modelling the integrated fractionation process. Dispersity reduct

Background: In recent years, there has been growing awareness of the distinct characteristics of adolescents and young adults (AYA) diagnosed with cancer. Soft-tissue sarcoma (STS) accounts for approximately 1% of all cancers diagnosed in adults and 8% of cancers diagnosed in AYA. To the best of our knowledge, only a few sarcoma registers include data regarding histological subtype, age at diagnos

Purpose: Epidemiologic evidence supports an association between high mammographic density and increased breast cancer risk yet etiologic mechanisms remain largely unknown. Mixed evidence exists as to whether circulating lipid levels influence mammographic density and breast cancer risk. Therefore, we examined these associations in the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHSII),

Under the Sign of Regret focuses on aesthetically mediated responses to regret. It interrogates the qualities of the feeling of regret as well as what is produced under its influence (as objects and as experiences). These two aims—considering regret as a mode and as a tool—hinge between two complementary definitions of aesthetics: on the one hand, the quality of feelings or the “distribution of th

Background: Genome-wide association studies (GWAS) have identified >50 single nucleotide polymorphisms (SNP) in association with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) but little is known about whether the combination of these SNPs may aid in prediction of future incidence of CKD in the population. Methods: We included 2301 participants with baseline eGFR ≥60

Motivation: Comparisons of microbiome communities across populations are often based on pairwise distance measures (beta-diversity). Standard analyses (principal coordinate plots, permutation tests, kernel methods) require access to primary data if another investigator wants to add or compare independent data. We propose using standard reference measurements to simplify microbiome beta-diversity a

Background: Although free fatty acids have been positively associated with risk factors for stroke, the role of plasma free fatty acids in the development of stroke has not been elucidated in older adults. Aims: We sought to examine the association between plasma free fatty acids and incident stroke. Methods: Prospective cohort of 4369 men and women ≥65 years of age in the Cardiovascular Health St