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INTRODUCTION: Breast cancer, a leading female cancer worldwide, can be influenced by mitochondrial dysfunction. Dysregulation of mitochondria by the nuclear genome may cause breast cancer initiation and progression. However, the comprehensive investigation of mitochondrial-related genes as prognostic marker for the overall survival of early-stage breast cancer patients is still limited.METHODS: To

BACKGROUND: Leukocytes have been reported to have tumor stimulating effects in colorectal cancer, among other malignancies. In line with this, earlier research has shown improved disease-free survival in patients with postoperative neutropenia compared to non-neutropenic patients following cytoreductive surgery (CRS) and hypertherm intraperitoneal chemotherapy (HIPEC).AIM: To evaluate the impact o

Understanding and quantifying the global methane (CH4) budget is important for assessing realistic pathways to mitigate climate change. CH4 is the second most important human-influenced greenhouse gas in terms of climate forcing after carbon dioxide (CO2), and both emissions and atmospheric concentrations of CH4 have continued to increase since 2007 after a temporary pause. The relative importance

A comprehensive treatise for methods for fatigue estimation and fatigue life prediction in randomly excited structural systems using th rainflow cycle counting method

We present a newly funded research program, DESCRYPT, aimed at deciphering and analyzing historical texts with rare or unknown scripts. The project leverages advancements in computational linguistics, artificial intelligence (AI), and image processing, alongside traditional philological methods, to develop innovative tools for transcription, recognition, and interpretation of historical writings w

Research on parapsychological (psi) phenomena is very relevant in the discussion of whether mental processes might go beyond the known limits of brain capacities. Nonetheless, most scientific and philosophical discussions of mind-brain relations do not even mention such research, despite showing similar empirical robustness to that of acknowledged mainstream research in psychology, medicine, and t

BACKGROUNDRecanalization sometimes fails during endovascular thrombectomy due to target vessel access failure. Two‐dimensional/3‐dimensional fusion imaging in the Siemens ARTIS Icono biplane platform may facilitate access by fusing the preoperative computed tomography angiography with procedural imaging. This observational study aimed to evaluate vascular access, success rates, and procedure times

BACKGROUND: Medium vessel occlusions (MeVO) can be either isolated events (primary), or secondary to thrombus migration from a large vessel occlusion to a medium-sized vessel. Outcomes following endovascular thrombectomy (EVT) in the middle cerebral artery (MCA) may differ between primary and secondary MeVOs. This study aimed to assess the association between primary/secondary MeVOs and clinical o

Intracerebral hemorrhage (ICH) carries the highest mortality and morbidity of all stroke types. Although small vessel disease accounts for the majority of ICH, there is a broad spectrum of other etiologies. Modern imaging techniques are a cornerstone of the work-up process. The goals of acute management are to prevent hematoma expansion, stabilize and prevent failure of vital functions, and establ

Introduction: Patients with substantial comorbidity burden are underrepresented in clinical trials on endovascular thrombectomy (EVT), despite being common in clinical routine care. Therefore, analysis of observational data is needed to evaluate how increasing comorbidity burden affects procedural success rate, complication rate, and clinical outcome following EVT. Patients and methods: We conduct

AIMS: Patients with heart failure (HF) and iron deficiency experience poor health-related quality of life (HRQoL). We evaluated the impact of intravenous (IV) ferric carboxymaltose (FCM) vs. placebo on HRQoL for the AFFIRM-AHF population.METHODS AND RESULTS: The baseline 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ-12), which was completed for 1058 (535 and 523) patients in the FCM and p

BACKGROUND: Long-term outcomes of percutaneous coronary intervention (PCI) for bifurcation lesions are underexplored. We investigated long-term PCI outcomes for proximal LAD bifurcation lesions involving D1.METHODS: Using Swedish registries, we included all patients undergoing LAD-D1 bifurcation PCI with drug-eluting stents between 2010 and 2020. Patients were stratified into two groups: simple PC

AIMS: Comparisons of international practice patterns and their impact on percutaneous coronary intervention (PCI) outcomes are lacking. We compared temporal PCI trends between Sweden and a large university hospital system in the US.METHODS AND RESULTS: Data within the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) and the University of California San Diego Health internal National C

Pre-and postoperative photos to assess results are widely used in plastic and reconstructive surgery, for instance, in patients with cleft lip and palate (CL/P). Evaluations are often performed by assessment panels by viewing the photos. However, these are prone to be subjective. Measurements of soft tissues in photos could be an alternative method but have not been widely used so far. Some patien

In this study, we report on reactive large-eddy simulations (LESs) of flow and combustion in the U.S. Air Force Research Laboratory Research Cell 19 cavity-based scramjet combustor. This case involves the combustion of ethylene that is injected into a cavity. It has previously been studied experimentally with multiple techniques, including particle image velocimetry, hyperspectral imagining, and l

We have investigated the adsorption of the amyloid-forming protein a-Synuclein (aSyn) onto small unilamellar vesicles composed of a mixture of zwitterionic POPC and anionic POPS lipids. aSyn monomers adsorb onto the anionic lipid vesicles where they adopt an a-helical secondary structure. The degree of adsorption depends on the fraction of anionic lipid in the mixed lipid membrane, but one needs t