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Genomewide association study on monoclonal gammopathy of unknown significance (MGUS)

OBJECTIVES: To identify germ line variants contributing to the development of monoclonal gammopathy of undetermined significance (MGUS), an asymptomatic premalignant precursor for multiple myeloma (MM).METHODS: We conducted the first genomewide association study (GWAS) on MGUS on 243 German cases with a replication on 294 Czech cases. Identified loci were further analyzed in 1508 German MM patient

Cellulase cross-linked enzyme aggregates (CLEA) activities can be modulated and enhanced by precipitant selection

BACKGROUND: Crosslinked enzyme aggregates (CLEA) technology is a rapid and versatile method to produce immobilized enzymes via precipitation and cross-linking. A direct relationship between CLEA final activity and process parameters is however yet to be clarified. To address the issue, we have used a factorial design to test the formation and optimization of CLEA made from technical grade cellulas

Impact of the Swedish National Stroke Campaign on stroke awareness

Background: Time delay from stroke onset to arrival in hospital is an important obstacle to widespread reperfusion therapy. To increase knowledge about stroke, and potentially decrease this delay, a 27-month national public information campaign was carried out in Sweden. Aims: To assess the effects of a national stroke campaign in Sweden. Methods: The variables used to measure campaign effects wer

Search for new phenomena in final states with large jet multiplicities and missing transverse momentum with ATLAS using √s=13 TeV proton-proton collisions

Results are reported of a search for new phenomena, such as supersymmetric particle production, that could be observed in high-energy proton-proton collisions. Events with large numbers of jets, together with missing transverse momentum from unobserved particles, are selected. The data analysed were recorded by the ATLAS experiment during 2015 using the 13 TeV centre-of-mass proton-proton collisio

Perceptions of Volunteerism by Young People of Macau and How this has influenced the Market Performance of the Non-Profits

This study investigated the perceptions of the young citizens of Macau about volunteerism, and how this perception affected volunteer reruitment and retention, and the market strategies of the non-profits. The study covered implicitly the question of competition and substitution of volutneerism as perceived by the young people in Macau; how the non-profits competed with each other in recruiting vo

Direct numerical simulation study of statistically stationary propagation of a reaction wave in homogeneous turbulence

A three-dimensional (3D) direct numerical simulation (DNS) study of the propagation of a reaction wave in forced, constant-density, statistically stationary, homogeneous, isotropic turbulence is performed by solving Navier-Stokes and reaction-diffusion equations at various (from 0.5 to 10) ratios of the rms turbulent velocity U′ to the laminar wave speed, various (from 2.1 to 12.5) ratios of an in

Different organization of collagen fibrils in stress-incontinent women of fertile age

OBJECTIVE: The objective was to test the hypothesis that stress urinary incontinence in women is correlated to changes in the paraurethral connective tissue ultrastructure and metabolism.METHODS: Transvaginal biopsies were obtained from the paraurethral connective tissue in women of fertile age with stress urinary incontinence and in matched continent controls. All the stress-incontinent women wer

5G : A tutorial overview of standards, trials, challenges, deployment, and practice

There is considerable pressure to define the key requirements of 5G, develop 5G standards, and perform technology trials as quickly as possible. Normally, these activities are best done in series but there is a desire to complete these tasks in parallel so that commercial deployments of 5G can begin by 2020. 5G will not be an incremental improvement over its predecessors; it aims to be a revolutio

Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer

Tamoxifen therapy resistance constitutes a major cause of death in patients with recurrent estrogen receptor (ER) positive breast cancer. Through high resolution mass spectrometry (MS), we previously generated a 4-protein predictive signature for tamoxifen therapy outcome in recurrent breast cancer. ANXA1 and CALD1, which were not included in the classifier, were however the most differentially ex

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This study aims to examine the effectiveness of the narrative tools in the modern Arabic poetry and take Al-baradony poetry as a model because it is a fertile field for academic studies and is as diverse as the curriculum to be studied by way of applications It has been studied in some respects and is still under taken for reasons. This study tries to examine the phenomenon of narrative style Al-b

Applications of optical DNA mapping in microbiology

Optical mapping (OM) has been used in microbiology for the past 20 years, initially as a technique to facilitate DNA sequence-based studies; however, with decreases in DNA sequencing costs and increases in sequence output from automated sequencing platforms, OM has grown into an important auxiliary tool for genome assembly and comparison. Currently, there are a number of new and exciting applicati

On Motion Control and Machine Learning for Robotic Assembly

Industrial robots typically require very structured and predictable working environments, and explicit programming, in order to perform well. Therefore, expensive and time-consuming engineering work is a major obstruction when mediating tasks to robots. This thesis presents methods that decrease the amount of engineering work required for robot programming, and increase the ability of robots to ha

Measurement of W+W-production in association with one jet in proton-proton collisions at √s = 8 TeV with the ATLAS detector

The production of Wboson pairs in association with one jet in pp collisions at √s = 8 TeV is studied using data corresponding to an integrated luminosity of 20.3 fb-1collected by the ATLAS detector during 2012 at the CERN Large Hadron Collider. The cross section is measured in a fiducial phase-space region defined by the presence of exactly one electron and one muon, missing transverse momentum an

An advanced modeling study on the impacts and atmospheric implications of multiphase dimethyl sulfide chemistry

Oceans dominate emissions of dimethyl sulfide (DMS), the major natural sulfur source. DMS is important for the formation of non-sea salt sulfate (nss-SO42−) aerosols and secondary particulate matter over oceans and thus, significantly influence global climate. The mechanism of DMS oxidation has accordingly been investigated in several different model studies in the past. However, these studies had

Comprehensive assessment of meteorological conditions and airflow connectivity during HCCT-2010

Abstract. This study presents a comprehensive assessment of the meteorological conditions and atmospheric flow during the Lagrangian-type "Hill Cap Cloud Thuringia 2010" experiment (HCCT-2010), which was performed in September and October 2010 at Mt. Schmücke in the Thuringian Forest, Germany and which used observations at three measurement sites (upwind, in-cloud, and downwind) to study physical

Effect of Volatile Reactions on the Thermochemical Conversion of Biomass Particles

A numerical and experimental study on the conversion of a biomass particle is carried out to quantify the effect of homogeneous volatile combustion on the biomass pyrolysis. The numerical domain consists of a particle and its surrounding and the model considers detailed chemical kinetic mechanism for reaction of pyrolysis products. A detailed pyrolysis model is employed which provides the composit

A tunnel evacuation experiment on movement speed and exit choice in smoke

In order to increase the knowledge on human behaviour in smoke, an evacuation experiment was performed in a road tunnel in Stockholm in July 2014. Sixty-six participants, who were instructed to individually evacuate the tunnel, took part. Participants' walking speeds were measured in a smoke-filled section, as well as in a smoke-free section, of the tunnel. The walking speeds in non-irritant smoke