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Prognostic value of HER3 and HER2 alterations in colorectal cancer: Relationship with sidedness, KRAS and BRAF mutation status

Background Human epidermal growth factors 2 and 3 (HER2 and HER3) are members of the EGFR family that drives oncogenesis mainly through activation of the RAS-RAF-MEK-ERK pathway. While the prognostic value of HER2 and HER3 alterations in colorectal cancer (CRC) remains uncertain, KRAS and BRAF mutations confer resistance to targeted therapies and poor prognosis. Sidedness of the primary tumour has

Predictive outcome factors in the young patient treated with lumbar disc herniation surgery

OBJECTIVE: The aim of this study was to evaluate predictive factors for outcome after lumbar disc herniation surgery in young patients. METHODS: In the national Swedish spine register, the authors identified 180 patients age 20 years or younger, in whom preoperative and 1-year postoperative data were available. The cohort was treated with primary open surgery due to lumbar disc herniation between

Plasma protein profiling in a stage defined pancreatic cancer cohort – Implications for early diagnosis

Pancreatic ductal adenocarcinoma (PDAC) is a disease where detection preceding clinical symptoms significantly increases the life expectancy of patients. In this study, a recombinant antibody microarray platform was used to analyze 213 Chinese plasma samples from PDAC patients and normal control (NC) individuals. The cohort was stratified according to disease stage, i.e. resectable disease (stage

Informality currencies: a tale of Misha, his brigada and informal practices among Uzbek labour migrants in Russia

This article explores the role of informality among Uzbek construction workers in Russia. We start from a relationship that is based on economic reward and common interests and go on to explore the non-economic components of this relationship. Economically, the workers entrust their supervisor and agree to work for him for a given amount of money. However, this decision is also embedded in a non-e

Promotion of nitrifiers through side-stream bioaugmentation : A full-scale study

Bioaugmentation of nitrifiers from a side-stream treatment is an efficient method for boosting the mainstream process at a wastewater treatment plant (WWTP). Although this technology has been known for several years, the number of full-scale applications for it is limited. For a WWTP approaching its critical nitrogen load capacity, the benefits are doubled if the introduced side-stream treatment f

Criminal offending and the family environment : Swedish national high-risk home-reared and adopted-away co-sibling control study

Background: Criminal offending is strongly transmitted across generations. Aims: To clarify the contribution of rearing environment to crossgenerational transmission of crime. Method: Using Swedish national registries, we identified 1176 fullsibling and 3085 half-sibling sets from high-risk families where at least one sibling was adopted and the other raised by the biological parents. Results: Ris

Higher prevalence of type 2 diabetes in men than in women is associated with differences in visceral fat mass

Context: We have previously found that visceral fat is a stronger predictor for cardiovascular risk factors than body mass index (BMI). Objective: This study sought to investigate the prevalence of diabetes in elderly men and women in relation to objectively assessed visceral fat volume. Design and Setting: The cohort consisted of a population-based sample of 705 men and 688 women, all age 70 y at

Diatom blooms and associated vegetation shifts in a subarctic peatland : responses to distant volcanic eruptions?

We test the hypothesis that rich occurrences of diatoms observed at transitions between major peat units representing different vegetation communities in a peat sequence from subarctic northern Sweden reflect responses to acid deposition from the Samalas AD 1257 and Laki AD 1783/1784 eruptions. We observe sudden changes in the mire ecosystem and thereby in the trophic status and biogeochemical cyc

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Abstract: This thesis examines the non-dominant and self-subversive aspects of visuality in Roberto Bolaño’s 2666 through the lens of the philosophical discussion on representation, particularly in its post-structuralist context. The present research is grounded in the conviction that 2666 embodies the 20th-century crisis of representation and approaches the novel through an analysis of different

Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets

Tissue damage is usually regarded as a necessary price to pay for successful elimination of pathogens by the innate immune defense. Yet, it is possible to distinguish protective from destructive effects of innate immune activation and selectively attenuate molecular nodes that create pathology. Here, we identify acute cystitis as an Interleukin-1 beta (IL-1β)-driven, hyper-inflammatory condition o

Influence of a HTR2B stop codon on glucagon homeostasis and glucose excursion in non-diabetic men

Limited data are available about the role of the serotonin 2B (5-HT2B) receptor in the function of human islets. This study aimed to test whether the 5-HT2B receptor contributes to glucose, insulin, and glucagon homeostasis in humans, utilizing a hereditary loss-of-function gene mutation in the receptor, which causes a 50% reduction in the production of the receptor protein in heterozygotes. This

Mutations in CEP78 Cause Cone-Rod Dystrophy and Hearing Loss Associated with Primary-Cilia Defects

Cone-rod degeneration (CRD) belongs to the disease spectrum of retinal degenerations, a group of hereditary disorders characterized by an extreme clinical and genetic heterogeneity. It mainly differentiates from other retinal dystrophies, and in particular from the more frequent disease retinitis pigmentosa, because cone photoreceptors degenerate at a higher rate than rod photoreceptors, causing s

Usefulness of Serum B-Type Natriuretic Peptide Levels in Comatose Patients Resuscitated from Out-of-Hospital Cardiac Arrest to Predict Outcome

N-terminal pro-B-type natriuretic (NT-proBNP) is expressed in the heart and brain, and serum levels are elevated in acute heart and brain diseases. We aimed to assess the possible association between serum levels and neurological outcome and death in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA). Of the 939 comatose OHCA patients enrolled and randomized in the Targeted

Towards a political ecology of the digital economy : Socio-environmental implications of two competing value models

This article explores the socio-environmental implications of two different value models currently competing for dominance in the digital economy: the neo-feudal cognitive capitalism (NFCC) and the hypothetical case of mature peer production (HMPP). Using a systematisation that considers environmental effects of information and communication technologies as direct, indirect and structural, this ar

Anti-Stokes resonant x-ray Raman scattering for atom specific and excited state selective dynamics

Ultrafast electronic and structural dynamics of matter govern rate and selectivity of chemical reactions, as well as phase transitions and efficient switching in functional materials. Since x-rays determine electronic and structural properties with elemental, chemical, orbital and magnetic selectivity, short pulse x-ray sources have become central enablers of ultrafast science. Despite of these st