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Selective sparing of hippocampal CA3 cells following in vitro ischemia is due to selective inhibition by acidosis.
Periplasmic c Cytochromes and Chlorate Reduction in Ideonella dechloratans
The aim of this study was to clarify the pathway of electron transfer between the inner membrane components and the periplasmic chlorate reductase. Several soluble c-type cytochromes were found in the periplasm. The optical difference spectrum of dithionite-reduced periplasmic extract shows that at least one of these components is capable of acting as an electron donor to the enzyme chlorate reduc
The theoretical basis of a method to determine the fracture energy GF of concrete
RILEM Technical Committee 50 - Fracture Mechanics of Concrete, has put forward a proposal for a recommendation for the determination of the fracture energy G//F of mortar and concrete. The significance of G//F in the strength of concrete structures is discussed and it is demonstrated that G//F in some cases, for example for shear failure of beams and slabs without shear reinforcement, is a materia
Environmental supply chain management, ISO 14001 and RoHS. How are small companies in the electronics sector managing?
This study explores the use of environmental management systems for initiating and controlling environmental improvements in the context of supply chain cooperation. It examines how environmental requirements are reaching smaller companies in the electronics supply chain, especially in the light of recent legal changes such as enforcement of the RoHS Directive. It is based on qualitative interview
JunB Protects against Myeloid Malignancies by Limiting Hematopoietic Stem Cell Proliferation and Differentiation without Affecting Self-Renewal
Loss of the JunB/AP-1 transcription factor induces a myeloproliferative disease (MPD) arising from the hematopoietic stem cell (HSC) compartment. Here, we show that junB inactivation deregulates the cell-cycle machinery and increases the proliferation of long-term repopulating HSCs (LT-HSCs) without impairing their self-renewal or regenerative potential in vivo. We found that JunB loss destabilize
Decomposition Reactions and Reversibility of the LiBH4-Ca(BH4)(2) Composite
LiBH4 is one of the promising candidates for hydrogen storage materials because of its high gravimetric and volumetric hydrogen capacity. However, its high dehydrogenation temperature and limited reversibility has been a hurdle for its use in real applications. In an effort to overcome this barrier and to adjust the thermal stability, we make a composite system LiBH4-Ca(BH4)(2). In order to fully
Holocene climatic and environmental changes inferred from midge records (Diptera : Chironomidae, Chaoboridae, Ceratopogonidae) at Lake Berkut, southern Kola Peninsula, Russia
A radiocarbon-dated sediment sequence from Lake Berkut in the southern part of the Kola Peninsula, northwest Russia, was investigated by means of midge analysis in order to reconstruct the Holocene climatic and environmental history of the region. Past mean July air temperatures at the study site and hypolimnetic oxygen contents of the lake water were inferred from chironomid-based transfer functi
Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer
Introduction Manual interpretation of immunohistochemistry (IHC) is a subjective, time-consuming and variable process, with an inherent intra-observer and inter-observer variability. Automated image analysis approaches offer the possibility of developing rapid, uniform indicators of IHC staining. In the present article we describe the development of a novel approach for automatically quantifying o
Gelled polymerizable microemulsions. 2. Microstructure
Using bicontinuous microemulsions as templates opens a new field for the design of novel structures and thus novel materials, but has significant challenges due to the very small composition and temperature windows in which microemulsions are bicontinuous. In previous work we had shown that we can take a ternary base system (water-n-dodecane-C13/15E5), add monomer and cross-linker (N-isopropylacry
Double-strand break DNA repair genotype predictive of later mortality and cancer incidence in a cohort of non-smokers
We followed-up for mortality and cancer incidence 1088 healthy non-smokers from a population-based study, who were characterized for 22 variants in 16 genes involved in DNA repair pathways. Follow-up was 100% complete. The association between polymorphism and mortality or cancer incidence was analyzed using Cox Proportional Hazard regression models. Ninety-five subjects had died in a median follow
Male golden egg bugs (Phyllomorpha laciniata Vill.) do not preferentially accept their true genetic offspring; comment on the paper by García-González et al. (2005, Ecological Entomology, 30, 444-455)
Migration as a risk factor for schizophrenia: a Danish population-based cohort study.
Background A growing body of evidence suggests that migration is a risk factor for the development of schizophrenia, although the putative mechanism remains obscure. Aims To examine immigrant background and history of foreign residence as risk factors for schizophrenia. Method Using data from the Danish Civil Registration System, we established a population-based cohort of 2.14 million persons r
Direct measurement of intraparticle fluid velocity in superporous agarose beads
Superporous agarose beads contain both normal diffusion pores and special, very wide superpores through which part of the chromatographic flow is transported, a situation that may greatly improve the chromatographic performance. For the first time such pore flow was measured directly by following the movement of microparticles (dyed yeast cells) through superporous beads packed in a chromatographi
Migration speed and scheduling of annual events by migrating birds in relation to climate change
Empirical evidence for changed timing of migration in birds is emerging from both American and Euro-African migration systems. These changes are usually interpreted as a consequence of changes in climate. Responses in timing of migration and breeding may differ among species, and the adaptive significance is not well understood. There is a lack of theoretical understanding about time-shifts in lif
The future of PID control
This paper presents the state of the art of PID control and reflectson its future. Particular issues discussed include specifications,stability, design, applications, and performance of PID control. Thepaper ends with a discussion of alternatives to PID and its future.
A novel coronary heart disease risk evaluation and communication program improves modifiable risk factors and understanding in patients with hypertension: The Risk Evaluation and Communication Health Outcomes and Utilization Trial
Cerebral Inflammatory Response after Fetal Asphyxia and Hyperoxic Resuscitation in Newborn Sheep.
Resuscitation with pure oxygen at birth after fetal asphyxia may aggravate brain damage by inducing pro-inflammation. The toll-like receptors (TLRs) may serve a pro-inflammatory role in hyperoxemia during ischemia-reperfusion. Sixteen near-term fetal sheep (132-136 d) were subjected to 10 min of cord occlusion, delivery and mechanical ventilation with 100% O-2 (n = 8), or 21% O-2 (n = 8) for 30 mi
Two episodes of digital vasculitis in a patient with rheumatoid arthritis (RA) treated with anti-tumor necrosis factor-alpha (TNF-alpha): case report
Bandsawing. Part III: stress analysis of saw tooth microgeometry
This article presents a stress analysis of a saw tooth. The analysis aims to determine the stress distribution for various egde load and varying microgeometry. The analysis is performed on a three-dimensional finite element model representing the tip of a saw tooth. The 3D model makes it possible to model the load distribution and study stress distributions across the width of the teeth with a suf