BACKGROUND: Apalutamide is an inhibitor of the ligand-binding domain of the androgen receptor. Whether the addition of apalutamide to androgen-deprivation therapy (ADT) would prolong radiographic progression-free survival and overall survival as compared with placebo plus ADT among patients with metastatic, castration-sensitive prostate cancer has not been determined.METHODS: In this double-blind,

Solutions for propagating mode III cracks in elastic perfectly-plastic solids are obtained as the limit solutions for infinitesimal crack tip speed and infinitesimal linear strain-hardening. The solution for a perfectly plastic material by Chitaley and McClintock (1971, J. Mech. Phys. Solids 19, 147) is not obtained. A point above or below the crack plane will experience first a centred-fan slip l

The injection strategy is commonly manipulated to control the stratification level to simultaneously achieve a low pollutant emission and a high efficiency in internal combustion engines. This paper reports on a joint experimental and numerical study of the emission characteristics and engine performance in a heavy-duty direct-injection compression ignition (DICI) engine operating in the HCCI and

Elastic—plastic anti‐plane strain problems can be solved by using FEM programs developed for plane stress. The technique does not involve any manipulations with the FEM code, but is merely a matter of specialization and of translation of notation. Two analytically solvable cases are chosen for demonstration.

Aims: In this article we explore the moderators of effectiveness of WISEteens (Web-based brief Intervention for SubstancE using teens), a fully automated web-based brief motivational intervention targeting risky substance use among adolescents. Based on previous studies, we examined the differential effects on drinking of sex, readiness to change, self-efficacy, alcohol risk status, and parental m

Elasto plastic analysis was performed to determine the conditions at the root of a notch in a CERT specimen and the conditions at a crack growing in a CERT specimen. Furthermore. analysis of growth under small scale yielding was performed in order to facilitate analysis of compact tension specimen. By experiments it was shown how the stress strain conditions affect initiation of intergranular crac

Early caregiving is one of the strongest influences on children's development, and among the most significant modifiable environmental factor. The aim of this study was to explore the association between quality of caregiver-infant interactions and neurodevelopment of infants living in banana-growing communities in rural Costa Rica characterized as having environmental toxic exposures. Home visits

Background: Can we validate a contagion model for drug abuse (DA) in Propinquity-of-Rearing Defined Acquaintances (PRDAs)? Methods: PRDAs were defined as pairs of same-age males born 1975–1990 who grew up within 2 km of each other, one of whom (PRDA1) being first registered for DA in national registries. Using adult residential location, we predicted, using regression splines, proximity-dependent