Compound input from genetic predisposition, environmental factors and lifestyle lead to beta-cell dysfunction which initiates the development of type 2 diabetes. Understanding the linkage between the environmental input and gene regulatory pathways controlling beta-cell function is key for developing novel therapies against T2D. The pancreatic beta-cell is controlled by ion channels. Voltage-gated

To the Editor: The lessons that Dr. Bailar gleaned from the recent dioxin study by Fingerhut et al. of the National Institute of Occupational Safety and Health (Jan. 24 issue)1 reached far beyond, and at times contradicted, what the authors presented.2 Moreover, Bailar did not acknowledge the growing body of evidence suggesting that low-level dioxin exposure does not present a risk of cancer in hu

Epidemiological studies on the aetiology of multiple myeloma are reviewed as a background to this population based case-control study performed in an area with a high incidence of multiple myeloma. The purpose was to identify and evaluate several suspected environmental factors in relation to this disease. A total of 275 confirmed cases diagnosed in four counties in northern Sweden during four yea

In a population-based case-control study in Sweden on multiple myeloma, the occurrence of different diseases in relatives, particularly hematologic malignancies and different types of cancer, was investigated. Through a questionnaire mailed to all living subjects, i.e. cases and controls, and to the next-of-kin for deceased subjects, information was obtained on malignant and certain other diseases

In a double blind randomised multicentre study the effect of intravenous clodronate plus hydration was compared with placebo plus hydration in the treatment of hypercalcaemia in breast cancer patients with bone metastases. The patients were treated either with hydration plus clodronate 300 mg/day or hydration plus placebo, up to 7 days or until serum ionised calcium was below 1.4 mmol/l. 25 patien

The polarization observables T,E,P,H, and G in photoproduction of η mesons off protons are measured for photon energies from threshold to W=2400 MeV (T), 2280 MeV (E), 1620 MeV (P,H), or 1820 MeV (G), covering nearly the full solid angle. The data are compared to predictions from the SAID, MAID, JüBo, and BnGa partial-wave analyses. A refit within the BnGa approach including further data yields pr

The Swedish Cancer Environment Register (CER) is a linkage of census data (e.g., on occupations) with the Swedish Cancer Register. It has been used in different studies to generate hypotheses on occupational risk factors for malignant tumors. In this study the risk for malignant lymphoma and multiple myeloma in occupations with potential exposure to phenoxyacetic acids or other related substances

KEY MESSAGE: We show the usefulness of integrating effector screening in a breeding program and in resistance gene cloning, with Phytophthora resistance in the Swedish potato breeding clone SW93-1015 as an example. Phytophthora infestans is one of the most devastating plant pathogens worldwide. We have earlier found that the SW93-1015 potato breeding clone has an efficient resistance against P. in

This population-based case-control investigation was designed to study the importance of rheumatoid arthritis, other diseases and different types of treatment for the risk of developing multiple myeloma. In total, 275 cases with verified myeloma in northern Sweden were matched to as many control subjects. Information about different diseases, drug use, diagnostic X-ray investigations and radiother

The plant secretome refers to the set of proteins secreted out of the plant cell into the surrounding extracellular space commonly referred to as the apoplast. Secreted proteins maintain cell structure and acts in signaling and are crucial for stress responses where they can interact with pathogen effectors and control the extracellular environment. Typically, secreted proteins contain an N-termin

Phytophthora is the most devastating pathogen of dicot plants. There is a need for resistance sources with different modes of action to counteract the fast evolution of this pathogen. In order to better understand mechanisms of defense against P. infestans, we analyzed several clones of potato. Two of the genotypes tested, Sarpo Mira and SW93-1015, exhibited strong resistance against P. infestans

Bio-inspired crossover:Natural genomes are affected by various kinds of mutations, manifesting as variations in the genome. This includes modifications to individual base pairs (single nucleotide polymorphism, SNP), but also short insertions and deletions (indels), and variations in the position (translocations) or multiplicity (copy number variations) of genetic sequences. While SNPs are historic

Monolayers of C60 and the functionalised fullerene phenyl-C61-butyric acid methyl ester (PCBM) have been prepared on Au(1 1 1) by in situ electrospray deposition. The observation of super-spectator/super-Auger decay in resonant photoemission spectroscopy (RPES) of C60 confirms monolayers prepared using electrospray undergo ultra-fast charge transfer as per previous studies of C60 monolayers on Au(