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A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair

Integrins are ubiquitous transmembrane receptors that play crucial roles in cell-cell and cell-matrix interactions. In this study, we have determined the effects of the loss of beta1 integrins in keratinocytes in vitro and during cutaneous wound repair. Flow cytometry of cultured beta1-deficient keratinocytes confirmed the absence of beta1 integrins and showed downregulation of alpha6beta4 but not

Phosphodiesterases (PDEs) and PDE inhibitors for treatment of LUTS

Lower urinary tract (LUT) smooth muscle can be relaxed by drugs that increase intracellular concentrations of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Both of these substances are degraded by phosphodiesterases (PDEs), which play a central role in the regulation of smooth muscle tone. The distribution and functional significance of PDE enzymes vary in differ

Environmental barriers, functional limitations, and housing satisfaction among older people in Sweden: A longitudinal perspective on housing accessibility

This study aimed at describing environmental barriers in housing and functional limitations among older community-living people in Sweden, to provide knowledge of housing accessibility problems from a longitudinal perspective, and to shed some light on older people's subjective reflections on housing. Along with a study-specific questionnaire on subjective reflections on housing, the Housing Enabl

The beat-to-beat decay of cardiac contractility from highly potentiated levels is bi-exponential

In order to determine the mode of beat-to-beat decay of contractility from very high levels, we studied the beat-by-beat decay of cardiac contractility following potentiation. Such decay curves are normally analysed using a mono-exponential decay function, which assumes that a fixed fraction of activator calcium ions is recirculated from one beat to the next. We postulated that there might be devi

Tubular secretion of Tamm-Horsfall protein in type 1 (insulin-dependent) diabetes mellitus using a simplified enzyme linked immunoassay

The relationship between glomerular and tubular dysfunction and metabolic control in type 1 diabetes was studied. To that end the urinary excretion rates of albumin and Tamm-Horsfall protein as well as HbA1c levels were measured in 58 patients with different degrees of diabetic nephropathy and in 76 apparently healthy subjects matched for sex and age. The urinary Tamm-Horsfall protein levels were

Aggregation of lignin derivatives under alkaline conditions. Kinetics and aggregate structure

The kinetics of kraft lignin (KL) aggregation at alkaline conditions was studied by quasi-elastic light scattering (QELS) and turbidity measurements. Stability ratios (W) for HL were obtained at 70 degreesC and various concentrations of sodium chloride. By analyzing the early-time evolution data of aggregate growth obtained from QELS, fractal dimensions of flocs formed in both reaction-limited clu

Bacterial vaginosis: a threat to reproductive health? Historical perspectives, current knowledge, controversies and research demands

Bacterial vaginosis is a change in flora, the cause of which is still unknown in the vast majority of instances. Bacterial vaginosis has generally been used to represent any change in vaginal flora resulting in an assumed loss of lactobacilli. However, whether such a flora represents the genetically normal state of some women is poorly defined. The present 'crude' diagnosis of bacterial vaginosis

A comparison of neuropsychological tests for the assessment of chronic toxic encephalopathy

BACKGROUND: From the viewpoint of the clinical neuropsychologist, it is not evident if the detection of solvent induced toxic encephalopathy (TE) could be optimized by a modification of the traditional test batteries, adding tests covering new dimensions or monitoring further functional domains. METHODS: To clarify this issue, TE patients were re-examined with (a) the tests traditionally used in s

Air sampling of its pheromone to monitor the occurrence of Osmoderma eremita, a threatened beetle inhabiting hollow trees

Osmoderma eremita is a threatened scarab beetle living in the hollows of old deciduous trees and is regarded as an umbrella species of the beetle fauna associated with this habitat. Several methods like pitfall trapping and wood mould sampling have been used to monitor the occurrence of O. eremita, but these methods cannot be applied for trees with certain characteristics. Recently, (R)-(+)--decal

Consequences of metabolic challenges on hypothalamic colipase and PLRP2 mRNA in rats.

The hypothalamus is the main appetite-regulating center in the brain receiving peripheral signals regarding the metabolic status of the body. Pancreatic procolipase has recently been identified in rat hypothalamus. Procolipase is known mainly for its actions in the intestine where it is cleaved to colipase, an enzyme required for the maintenance of pancreatic lipase activity, and enterostatin, a p

Expression of TGF-beta isoforms, TGF-beta receptors, and SMAD molecules at different stages of human glioma

Human gliomas express TGF-beta but, so far the expression of downstream mediators has been investigated in only a few cell lines. We have examined tissue specimens of 23 gliomas: 3 astrocytomas grade II (AST), 8 anaplastic astrocytomas grade III (AAST), and 12 glioblastoma multiforme grade IV (GBM). We analyzed the mRNA expression of TGF-beta1, TGF-beta2, TGF-beta3, the TGF-beta receptors type I (

Hur lär man sig socialt arbete i Norden?

På socionomutbildningarna i Norden skall studenterna både praktiskt och teoretiskt lära sig socialt arbete. I artikeln redovisas resultat från en undersökning av vilket teoretiskt innehåll socionomutbildningarna lägger i ämnet, hur det integreras i utbildningen och vem som undervisar i ämnet.

Testis hormone-sensitive lipase expression in spermatids is governed by a short promoter in transgenic mice

A testicular form of hormone-sensitive lipase (HSLtes), a triacylglycerol lipase, and cholesterol esterase, is expressed in male germ cells. Northern blot analysis showed HSLtes mRNA expression in early spermatids. Immunolocalization of the protein in human and rodent seminiferous tubules indicated that the highest level of expression occurred in elongated spermatids. We have previously shown that

The Impact of Hospital Volume on Surgical Outcome in Patients with Rectal Cancer

PURPOSE: This study was designed to investigate, in a population-based setting, the surgical outcome in patients with rectal cancer according to the hospital volume. METHODS: Since 1995 all patients with rectal cancer have been registered in the Swedish Rectal Cancer Registry. Hospitals were classified, according to number treated per year, as low-volume, intermediate-volume, or high-volume hospit

Effects of N and P fertilization on the greenhouse gas exchange in two northern peatlands with contrasting N deposition rates

Peatlands are important ecosystems in the context of biospheric feedback to climate change, due to the large storage of organic C in peatland soils. Nitrogen deposition and increased nutrient availability in soils following climate warming may cause changes in these ecosystems affecting greenhouse gas exchange. We have conducted an N and P fertilization experiment in two Swedish bogs subjected to

Toxicological findings and manner of death in autopsied users of anabolic androgenic steroids

With the aim to characterize patterns in toxicological profile and manner of death in deceased users of anabolic androgenic steroids (AAS), a retrospective autopsy protocol study of 52 deceased users of AAS was undertaken. The AAS users were compared to 68 deceased users of amphetamine and/or heroin who were consecutively tested and found to be negative for AAS. Use of AAS was in the majority of c

Prenatal restraint stress and long-term affective consequences

Chronic or repeated stress during critical periods of human fetal brain development has been associated with various learning, behavioral and/or mood disorders in later life. In this investigation, pregnant Fischer 344 rats was individually restrained three times a day for 45 min during the last week of gestation in transparent plastic cylinders while at the same time being exposed to bright light