BACKGROUND: The FFAR1 receptor is expressed mainly in pancreatic beta cells and is activated by medium to long chain free fatty acids (FFAs), as well as by thiazolidinediones, resulting in elevated Ca(2+) concentrations and promotion of insulin secretion. These properties suggest that FFAR1 could be a mediator of lipotoxicity and a potential candidate gene for Type 2 diabetes (T2D). We therefore i

Study Design. Descriptive register studyObjective. To describe preoperative levels of leg and back pain in patients operated for lumbar spinal stenosis and to obtain information on how three different pain constellations (back pain < leg leg pain, back pain > leg pain, back pain = leg pain) correlate to HRQoL and function in different morphological types of stenosis.Summary of Background Data. Deg

When swimming, the lamprey maintains a definite orientation of its body in the vertical planes, in relation to the gravity vector, as the result of postural vestibular reflexes. Do the vestibular-driven mechanisms also play a role in the control of the direction of swimming in the horizontal (yaw) plane, in which the gravity cannot be used as a reference direction? In the present study, we address

Analyse go south Swedish silver hoards according to geography, chronology and origin of the objects. Is is claimed that the silver mainly is to be seen as collections of means of payment.

The aim of this thesis was to characterize a personal denuder/filter sampler for isocyanate aerosol and to study the emission of airborne particles from the interaction between studded tires and pavements. Both types of aerosols are highly relevant for health studies in public and occupational environments. The adverse health effects of airborne isocyanate exposure are well known in the occupatio

BACKGROUND: Maintenance of the botanical integrity of cereal kernels and the addition of acetic acid (as vinegar) in the product or meal has been shown to lower the postprandial blood glucose and insulin response and to increase satiety. However, the mechanism behind the benefits of acetic acid on blood glucose and satiety is not clear. We hypothesized that the gastric emptying rate could be invol

Objectives. Autoantibodies to apolipoprotein (apo) B-100 peptides are present in human plasma and have been shown to be associated with decreased cardiovascular risk. The present study aimed to determine if apo B-100 peptide vaccines are atheroprotective in mice expressing human apo B-100 and if the effectiveness of the vaccines is influenced by the level of pre-existing peptide-specific autoantib

Most genetic disorders are linked to missense mutations as even minor changes in the size or properties of an amino acid can alter or prevent the function of the protein. Further, the effect of a mutation is also dependent on the sequence and structure context of the alteration.