Following previous electrochemical investigations of cellobiose dehydrogenase (CDH), the present investigation reports on the initial screening of the electrochemistry of three new CDHs, two from the white rot basidiomycetes Trametes villosa and Phanerochaete sordida and one from the soft rot ascomycete Myriococcum thermophilum, for their ability to directly exchange electrons with 10 different al

Popular Abstract in Swedish Bakgrund När en kärlskada uppstår är det viktigt att blödningen snabbt kan stoppas. Detta åstadkomms genom att koagulationssystemet bildar en blodpropp vid skadestället. Von Willebrand faktorn (VWF) är ett stort protein som cirkulerar i blodet. Detta protein ingår, tillsammans med blodplättarna, i koagulationssystemets första fas. När ett kärl skadas binder VWF (som seVon Willebrand factor (VWF) is synthesized and secreted by endothelial cells into the plasma as a series of multimers. VWF induces the formation of platelet plugs at sites of vascular injury and high shear stress. Biological activity is dependent on multimeric size, which is regulated in plasma by the VWF-cleaving protease ADAMTS13. Severe ADAMTS13 deficiency is associated with thrombotic thromboc

Popular Abstract in Swedish Neutrofiler försvarar oss mot sjukdomsframkallande mikroorganismer. Deras primära funktion är att känna igen, fagocytera och avdöda de invaderande mikroorganismerna. I denna avhandling studeras membrantrafik i neutrofiler och neutrofil-lika celler. Här visas att icke-opsoniserade S. pyogenes bakterier inducerar ett snabbt och lokaliserat pinocytossvar hos neutrofiler. PThe neutrophil constitutes the first line of defence against invading organisms and its primary function is to recognize, phagocytose and kill intruding microorganisms. In this thesis, the membrane traffic in neutrophils and neutrophil-like cells was studied. Non-opsonised S. pyogenes bacteria was shown to induce a rapid and localised pinosome formation in neutrophils. The pinocytosis was not an i

Dimethylaminopurine (DMAP) has previously been used as an inhibitor of phosphorylation in studies of meiotic events, and more recently to investigate TNFα signaling, because of its potential to inhibit activation of c-jun N-terminal kinase (JNK). Here we have addressed the effects of DMAP on metabolic insulin responses in adipocytes and on intracellular insulin signaling molecules. At 100 μmol/L,

Ancient Italic terracottas were painted before or after firing depending on their function, as suggested by previous analyses. However, concerning the votive terracottas, there seems to have been no anlayses carried out, suggesting either a fired or non fired paint. Methods and problems associated with an ongoing research on some votive terracottas from Tessennano in Southern Etruria are considere

The reactive vascular-injuring amino acid homocysteine was measured in plasma samples from 79 well-characterized type 1 diabetic patients and 46 control subjects. Patients with proliferative retinopathy had higher homocysteine levels (15.0 +/- 6.3 mumols l-1; mean +/- SD, p less than 0.001; n = 42) than those with progressive retinopathy during a two-year period (10.4 +/- 1.6 mumols l-1; n = 12),

The colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was standardized for direct detection of rifampin-resistant Mycobacterium tuberculosis in sputum samples. The sensitivity and specificity of the direct MTT assay matched those of the standard indirect susceptibility assay on 7H10 medium, and interpretable results were obtained for 98.5% of the samples within

Renal cell carcinoma (RCC) is the most prevalent cancer of the kidney. In human RCC cells, we recently showed that insulin-like growth factor I (IGF-I) has growth-promoting effects regulated by IGF-binding protein 3 (IGFBP-3). In this study, the analysis was expanded to include the interaction between the IGF and transforming growth factor-beta (TGF-beta) systems in the human RCC cells Caki-2 (fro

The aim of this report is to study how the authorities in twelve Swedish municipalities consider social vulnerability in disasters. The study is based on telephone interviews with ten officials responsible for safety and risk analysis and with ten officials responsible for social and psychological support after disasters. Three group interviews about the support for affected citizens after the sto

Moments of the hadronic invariant mass and of the lepton energy spectra in semileptonic B decays have been determined with the data recorded by the DELPHI detector at LEP. From measurements of the inclusive b-hadron semileptonic decays, and imposing constraints from other measurements on b- and c-quark masses, the first three moments of the lepton energy distribution and of the hadronic mass distr

A search for pair-produced charged Higgs bosons was performed in the high energy data collected by the DELPHI detector at LEP II at centre-of-mass energies from 189 GeV to 202 GeV. The three different final states, taunutaunu, c (s) over bar(c) over bars and c (s) over bar taunu were considered. New methods were applied to reject wrong hadronic jet pairings and for the tau identification, where a