The costs and consequences of donepezil versus placebo treatment in patients with mild to moderate Alzheimer's disease (AD) were evaluated as part of a 1-year prospective, double-blind, randomized, multinational clinical trial. Patients received either donepezil (n = 142; 5 mg/day for 28 days followed by 10 mg/day according to the clinician's judgement) or placebo (n = 144). Unit costs were assess

INTRODUCTION: Despite favourable results from structured face-to-face treatment of osteoarthritis (OA) in Sweden through the Better management of patients with OsteoArthritis (BOA) initiative, only around 20% of people with knee or hip OA receive the primary treatment recommended by international guidelines (ie, information, exercise, weight management). In 2014, a digital treatment programme name

For an open set V subset of C-n, denote by M-alpha(V) the family of a-analytic functions that obey a boundary maximum modulus principle. We prove that, on a bounded "harmonically fat" domain Omega subset of C-n, a function f is an element of M-alpha (Omega\f(-1)(0)) automatically satisfies f is an element of M-alpha(Omega), if it is C alpha j-1-smooth in the z(j) variable, alpha is an element of Z

I ”En allians av något slag” ger Mikael Hermansson ny kunskap om den sällan skildrade relationen mellan Svenska kyrkan och Church of England, och erbjuder nya perspektiv på det stora, svenska skiftet under 1900-talet – från en tysk kultursfär till en anglosaxisk.Redan vid slutet av 1800-talet visade Church of England ett gryende intresse för Svenska kyrkan. De ville upprätta ”en allians av något sWith a certain definition of ”networks”, “trust” and “change” this thesis makes new inroads into the historiography of bilateral church relations. Applied to the ambitions of establishing a deeper connection between the Church of Sweden and the Church of England, it’s aim is to show how a social network of leaders – mostly bishops and priests – from both churches came to be the formative centre of

The production of blood cells is sustained throughout the lifetime of an individual by haematopoietic stem cells (HSCs). Specification of HSCs from mesoderm during embryonic development requires the stem cell leukaemia SCL/tal-1 gene product. Forced expression of SCL/tal-1 strongly induces blood formation in embryos, indicating that this gene has a dominant role in commitment to haematopoiesis. In

The 100 000 Genome Project aims to develop a diagnostics platform by introducing whole genome sequencing (WGS) into clinical practice. Samples from patients with chronic lymphocytic leukaemia were subjected to WGS. WGS detection of single nucleotide variants and insertion/deletions were validated by targeted next generation sequencing showing high concordance (96·3%), also for detection of sub-clo

Alla ryggradsdjur har ett immunförsvar vars funktion är att skydda oss mot mikroorganismer som kan orsaka sjukdom, såsom bakterier och virus. Dessa sjukdomsframkallande ämnen kallas patogener. Immunförsvaret behöver kunna skilja mellan proteiner som kommer från den egna kroppen och från patogener. Molekylerna som kodas av gener i major histocompatibility complex (MHC) har en viktig del i denna igeThe function of the vertebrate immune system is to enable recognition and elimination of microorganisms that can cause harm (pathogens). A key component in adaptive immunity is the major histocompatibility complex (MHC) that codes for molecules with antigen presentation function. There are two main types of MHC molecules, class-I (MHC-I) and class-II (MHC-II) and the focus of my thesis has been MH

In the study presented in this paper, a vehicle driving cycle simulation of the pneumatic hybrid has been conducted. The pneumatic hybrid powertrain has been modeled in GT-Power and validated against experimental data. The GT-Power engine model has been linked with a MATLAB/simulink vehicle model. The engine in question is a single-cylinder Scania D12 diesel engine, which has been converted to wor

Although folk culture in Yemen is characterised by respect for women and their role in society, folktales contain stereotypical patterns that are not very different from the negative portrayals of women in other media. Folktales in Yemen create a negative image of women, but this image is hidden under the aesthetic aspect, as cultural patterns embedded in the consolidation of this negative image.

The Charter of the United Nations emphasizes the importance of freedom of expression as well as the Universal Declaration of Human Rights. However, freedom of expression and press freedoms are at their worst, especially in the Middle East, and in Yemen in particular. While there are violations against journalists, there are serious violations committed by journalists and press institutions that th

In laser-wakefield acceleration (LWFA), a femtosecond laser pulse is tightly focused in a gas to intensities exceeding 1018 W/cm2 . The laser radiation ionizes the medium and excites a plasma wave that travels behind the laser pulse. Electrons can be trapped in the oscillations in the plasma density, where electric fields of the order of several hundreds of GV/m accelerate them to relativistic ene