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Epigenetic Regulation of Tissue-Type Plasminogen Activator in Human Brain Tissue and Brain-Derived Cells.

The serine protease tissue-type plasminogen activator (t-PA) is involved in both vital physiological brain processes, such as synaptic plasticity, and pathophysiological conditions, such as neurodegeneration and ischemic stroke. Recent data suggest that epigenetic mechanisms play an important role in the regulation of t-PA in human endothelial cells. However, there are limited data on epigenetic r

Sleepiness or fatigue? Can we detect treatable causes of tiredness in primary Sjogren's syndrome?

Objective. To study the prevalence of fatigue and daytime sleepiness in primary SS (pSS) and analyse predicting sleep disturbing factors and other potential determinants of fatigue and sleepiness. Method. Seventy-two consecutive pSS patients and 59 age-matched healthy controls were compared. Assessment instruments were profile of fatigue (ProF), visual analogue scale fatigue, Epworth Sleepiness Sc

Natural remedy use in a prospective cohort of breast cancer patients in southern Sweden.

Abstract Background. Complementary and alternative medicine (CAM) use is common among breast cancer patients. Several CAM therapies may have negative side effects or interact with conventional therapies. We studied biologically based CAM use with and without vitamins/minerals in relation to patient and tumor characteristics as well as treatment in an ongoing prospective cohort of 855 primary breas

Benchmarking plant operation and instrumentation, control and automation in the wastewater industry

Benchmarking is an effective tool to compare the performance of full-scale wastewater treatment plant operation. In this study, 29 wastewater treatment plants from eight countries were surveyed with the aim of developing some key performance indicators, which may be used for benchmarking purposes. The level of utilisation of instrumentation, control and automation (ICA) has also been measured. The

Excess mortality in middle-aged men with diabetes aged 15-34 years at diagnosis.

The aim of this study is to assess mortality risk and the excess of risk in patients with diabetes. Patients were 15-34 years old at diagnosis of diabetes mellitus (n = 879) in 1992 and 1993 in this national cohort from Sweden. Healthy controls were matched for gender and birth on the same day as the index cases (n = 837). The civic registration number was used to link patients and controls to the

Uppdragsarkeologins publika sida: Slättbygdsprojektet

De arkeologiska utgrävningarna är den historiska forskningsinstitution som är starkast reglerat i lag, till och med fastare än historieämnets plats i skolundervisningen. Om en exploatör vill utnyttja mark där fornminne finns är det ett ovillkorat krav att platsen ska grävas ut och resultaten dokumenteras. I tider av expansion för bebyggelse och infrastruktur utvecklas därför institutionerna kring

Brain mitochondrial function in a murine model of cerebral malaria and the therapeutic effects of rhEPO.

Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum infection. The pathogenesis of CM is complex. Cerebral metabolic dysfunction is implicated in CM, which may be caused by both an impaired cerebral microcirculation and a dysregulated inflammatory response affecting cellular respiration of mitochondria. Recombinant human erythropoietin (rhEPO) is a promising new thera

Diagnostic methods for mastitis in cows are not appropriate for use in humans : Commentary

Healthcare workers are now being targeted for marketing of diagnostic tools for mastitis that were developed for the dairy industry and which aim to provide information regarding choice of antibiotic treatment. Meanwhile, scientists are striving to understand how the human microbiome affects health and wellbeing and the importance of maintenance of bacterial balance in the human body. Breast milk

Harmonic morphisms between spaces of constant curvature

Let M and N be simply connected space forms, and U an open and connected subset of M. Further let n: U-*N be a horizontally homothetic harmonic morphism. In this paper we show that if n has totally geodesic fibres and integrable horizontal distribution, then the horizontal foliation of U is totally umbilic and isoparametric. This leads to a classification of such maps. We also show that horizontal