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Extracellular vesicles (EVs) have been identified as important mediators of cancer metastasis, especially in the establishment of organ-specific metastatic niches. These membranous vesicles secreted by tumor cells release diverse bioactive cargo, including proteins, nucleic acids, and lipids, thereby allowing for intercellular communication and microenvironment modulation. Recent evidence demonstr

OBJECTIVE: Sarcopenia (loss of muscle strength/mass) reduces physical performance (walking, strength, mobility) and is common in Parkinson's disease (PD), but data on newly diagnosed, untreated patients ("de novo") are scarce. Fatigue is frequent in PD and linked to physical decline and malnutrition, key sarcopenia risk factors. We aimed to describe sarcopenia prevalence, malnutrition risk, and fa

AC-DC converters, which transform alternating current (AC) into controlled direct current (DC), are key instruments for systems requiring stable and efficient power conversion. Among various AC-DC topologies, the Cuk converter topology is increasingly used for power factor correction (PFC) applications, enabling efficient power conversion for various industrial and household devices. Despite its g

Since 2016, the city of Stockholm has been replacing one of the region’s most important communication hubs, the so-called Slussen (The Lock). This enormous building site is situated within the historical city area of Stockholm. For this reason, archaeologists have been involved throughout the process, mapping a giant historic topographic jigsaw puzzle. This paper is a meta-study of the archaeologiSince 2016, the city of Stockholm has been replacing one of the region’s most important communication hubs, the so-called Slussen (The Lock). This enormous building site is situated within the historical city area of Stockholm. For this reason, archaeologists have been involved throughout the process, mapping a giant historic topographic jigsaw puzzle. This paper is a meta-study of the archaeologi

Common proposals for classifying metonyms build on the contiguity of the meaningof a metonym compared to its original meaning. In contrast, this article offers amodel of metonymisation that focuses on the cognitive underpinnings and seesmetonymisation as an attentional process. By using event structure as a framework,we present a cognitive model of events that consists of four elements: actor, pat

Failure in change detection in the surrounding environment while driving is attributed among other things to the number of incidents and the density of them occurring along the task as this is directly related to an increase in cognitive load. Here, we investigate the role of time proximity between events on the detection performance during a naturalistic driving task in a virtual simulation. Part

Everyday tasks such as driving, and cycling, involve continuous predictions to fulfil the requirements of situation awareness. In these tasks, it is common for people to use predictions to address visual occlusion events or moments when information is out of sight as a result of human embodiment and natural locomotion. While the visual system is efficient in predicting small-scale visual actions (

Everyday driving relies on cognitive functions such as visual search, change detection and predictive attention for maintaining a high-level mental model of the world. Such functions are especially constrained by limited cognitive resources under complex conditions. Understanding the manner in which environmental complexity influences cognitive driving performance is key to improving road safety a

Archbishop Gustav Trolle worked for the freedom of the church. He was not afraid to compromise in certain circumstances if it served the church’s cause. His alliance with Christian II came later than is often presumed and was more reactive than calculated. Furthermore, the Bloodbath took place on a scale larger than Trolle had intended. His image has, however, been profoundly influenced by his ene

BACKGROUND: Insufficient knowledge among assistant nurses (ANs) in nursing homes (NHs) on medicines and drug-related problems (DRPs) in older people causes difficulties in acknowledging the side effects of medications, which can be harmful to the individual and endangers patient safety. The aim of this study was to explore the ANs' thoughts on their professional role in preventing DRPs in NH resid