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Two-step deswelling in the Volume Phase Transition of thermoresponsive microgels
Thermoresponsive microgels are one of the most investigated types of soft colloids, thanks to their ability to undergo a Volume Phase Transition (VPT) close to ambient temperature. However, this fundamental phenomenon still lacks a detailed microscopic understanding, particularly regarding the presence and the role of charges in the deswelling process. This is particularly important for the widely
The Concordance Index decomposition : A measure for a deeper understanding of survival prediction models
The Concordance Index (C-index) is a commonly used metric in Survival Analysis for evaluating the performance of a prediction model. In this paper, we propose a decomposition of the C-index into a weighted harmonic mean of two quantities: one for ranking observed events versus other observed events, and the other for ranking observed events versus censored cases. This decomposition enables a finer
Effect of Internal Architecture on the Assembly of Soft Particles at Fluid Interfaces
Monolayers of soft colloidal particles confined at fluid interfaces are at the core of a broad range of technological processes, from the stabilization of responsive foams and emulsions to advanced lithographic techniques. However, establishing a fundamental relation between their internal architecture, which is controlled during synthesis, and their structural and mechanical properties upon inter
Dynamical properties of different models of elastic polymer rings : Confirming the link between deformation and fragility
We report extensive numerical simulations of different models of 2D polymer rings with internal elasticity. We monitor the dynamical behavior of the rings as a function of the packing fraction to address the effects of particle deformation on the collective response of the system. In particular, we compare three different models: (i) a recently investigated model [N. Gnan and E. Zaccarelli, Nat. P
Charge affinity and solvent effects in numerical simulations of ionic microgels
Ionic microgel particles are intriguing systems in which the properties of thermo-responsive polymeric colloids are enriched by the presence of charged groups. In order to rationalize their properties and predict the behaviour of microgel suspensions, it is necessary to develop a coarse-graining strategy that starts from the accurate modelling of single particles. Here, we provide a numerical adva
Microgels at Interfaces Behave as 2D Elastic Particles Featuring Reentrant Dynamics
Soft colloids are increasingly used as model systems to address fundamental issues such as crystallization and the glass and jamming transitions. Among the available classes of soft colloids, microgels are emerging as the gold standard. Since their great internal complexity makes their theoretical characterization very hard, microgels are commonly modeled, at least in the small-deformation regime,
Tuning the rheological behavior of colloidal gels through competing interactions
We study colloidal gels formed by competing electrostatic repulsion and short-range attraction by means of extensive numerical simulations under external shear. We show that, upon varying the repulsion strength, the gel structure and its viscoelastic properties can be largely tuned. In particular, the gel fractal dimension can be either increased or decreased with respect to mechanical equilibrium
Numerical insights on ionic microgels : Structure and swelling behaviour
Recent progress has been made in the numerical modelling of neutral microgel particles with a realistic, disordered structure. In this work we extend this approach to the case of co-polymerised microgels where a thermoresponsive polymer is mixed with acidic groups. We compare the cases where counterions directly interact with microgel charges or are modelled implicitly through a Debye-Hückel descr
Microgels Adsorbed at Liquid-Liquid Interfaces : A Joint Numerical and Experimental Study
Soft particles display highly versatile properties with respect to hard colloids and even more so at fluid-fluid interfaces. In particular, microgels, consisting of a cross-linked polymer network, are able to deform and flatten upon adsorption at the interface due to the balance between surface tension and internal elasticity. Despite the existence of experimental results, a detailed theoretical u
Modelling realistic microgels in an explicit solvent
Thermoresponsive microgels are polymeric colloidal networks that can change their size in response to a temperature variation. This peculiar feature is driven by the nature of the solvent-polymer interactions, which triggers the so-called volume phase transition from a swollen to a collapsed state above a characteristic temperature. Recently, an advanced modelling protocol to assemble realistic, d
Fluctuating systems under cyclic perturbations : Relation between energy dissipation and intrinsic relaxation processes
This study focuses on fluctuating classical systems in contact with a thermal bath, and whose configurational energetics undergoes cyclic transformations due to interaction with external perturbing agents. Under the assumptions that the configurational dynamics is a stochastic Markov process in the overdamped regime and that the nonequilibrium configurational distribution remains close to the unde
Beyond Average : a-Particle Distribution and Dose Heterogeneity in Bone Metastatic Prostate Cancer
a-particle emitters are emerging as a potent modality for disseminated cancer therapy because of their high linear energy transfer and localized absorbed dose profile. Despite great interest and pharmaceutical development, there is scant information on the distribution of these agents at the scale of the a-particle pathlength. We sought to determine the distribution of clinically approved [223Ra]R
Microwave power harvesting using resonator-coupled double quantum dot photodiode
We demonstrate a microwave power-to-electrical energy conversion in a resonator-coupled double quantum dot. The system, operated as a photodiode, converts individual microwave photons to electrons tunneling through the double dot, resulting in an electrical current flowing against the applied voltage bias at input powers down to 1 fW. The device attains a maximum power harvesting efficiency of 2%,
Effects of certain pre-analytical factors on the performance of plasma phospho-tau217
Introduction: Pre-analytical factors can cause substantial variability in the measurements of cerebrospinal fluid (CSF) and plasma biomarkers of Alzheimer’s disease (AD). However, their effects on the performance of one of the most promising plasma AD biomarkers, phosphorylated tau (p-tau)217, are not known. Methods: We included 50 amyloid-β positive (Aβ+) and 50 Aβ− participants from the Swedish
Swedish musculoskeletal researchers view on a collaborative network and future research priorities in Swedish healthcare
Background: Musculoskeletal disorders (MSK) are a global burden causing significant suffering and economic impact. Systematic identification and targeting of research questions of highest interest for stakeholders can aid in improving MSK disorder knowledge and management. Objective: To obtain Swedish MSK researchers' opinions and views on a collaborative Swedish MSK network (SweMSK) and identify
Mass spectroscopy reveals compositional differences in copepodamides from limnic and marine copepods
Marine copepods, the most abundant animals in the global ocean, imprint their surrounding waters with chemical cues, called copepodamides. Copepodamides induce defensive traits such as toxin production, bioluminescence, and colony size plasticity in a variety of marine phytoplankton. The role of copepodamides in freshwater ecosystems is, however, unknown. Here we report the consistent presence of
Angle estimation using mmWave RSS measurements with enhanced multipath information
mmWave communication has come up as the unexplored spectrum for 5G services. With new standards for 5G NR positioning, more off-the-shelf platforms and algorithms are needed to perform indoor positioning. An object can be accurately positioned in a room either by using an angle and a delay estimate or two angle estimates or three delay estimates. We propose an algorithm to jointly estimate the ang
Graphite oxide by “chlorate route” oxidation without HNO3 : Does acid matter?
Very strong difference in many properties is well documented for graphite oxides (GtO) synthesized by Brodie (BGO) and Hummers (HGO) methods. The difference is typically assigned to the type of oxidant (chlorates or KMnO4, respectively). However, not only oxidants but also acids used in these methods are different. It is still unclear which of the different properties of GtO are dependent on the o
Gender effects in dictator game giving under voluntary choice of the recipient's gender : Women favour female recipients
Allowing for free choice of the recipient's gender in a dictator game (N=357), women give more frequently to their own gender (70.3% vs 9.4%) while men do not prefer a specific recipient's gender (33.3% vs 27.8%). Conditional on a positive transfer being made, the average amount of transfers to each gender does not vary between genders, though. Once a charity recipient is added to the possible cho
