Filetype
Uppenbarelseboken avtäcker med sina fasansfulla syner – sin Apokalyps – vad som ska ske på den yttersta dagen, då allt ont ska förgås och ett nytt rike ska upprättas. Men numera menas ofta med apokalyps enbart den skräckfyllda, mytologiska spådomen om en framtida katastrof. Kan man istället förstå Uppenbarelsebokens syner som en varning, för den katastrof vi själva är med om att skapa här och nu,
This paper presents a novel domain adaptation framework to enhance the accuracy of EEG-based auditory attention classification, specifically for classifying the direction (left or right) of attended speech. The framework aims to improve the performances for subjects with initially low classification accuracy, overcoming challenges posed by instrumental and human factors. Limited dataset size, vari
This paper presents views of six Dutch development NGOs on possibilities and threats of social media for their work. A systematic analysis of the literature and the systematic analysis of the interviews yield an interesting theoretical framework in which social media characteristics are cross-referenced with NGO organisational characteristics. The resulting preliminary framework of emerging themes
Electric power systems are undergoing huge changes due to the shift from conventional power production to more renewable-based generation like solar and wind. This is primarily driven by the need to mitigate climate change by reducing CO2 emissions. The shift to more generation from solar and wind will affect the dynamical behaviour of power systems, and consequently how they should be controlled.
SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.
Background: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are ubiquitous and persistent herpesviruses commonly acquired during childhood. Both viruses have a significant impact on the immune system, especially through mediating the establishment of cellular immunity, which keeps these viruses under control for life. Far less is known about how these viruses influence B-cell responses. Objecti
Following antigen encounter, two distinct processes modify immunoglobulin genes. The variable region is diversified by somatic hypermutation while the constant region may be changed by class-switch recombination. Although both genetic events can occur concurrently within germinal centre B cells, there are examples of each occurring independently of the other. Here we compare the contributions of c
B cells emerge from the bone marrow as transitional (TS) B cells that differentiate through T1, T2, and T3 stages to become naive B cells. We have identified a bifurcation of human B cell maturation from the T1 stage forming IgMhi and IgMlo developmental trajectories. IgMhi T2 cells have higher expression of α4β7 integrin and lower expression of IL-4 receptor (IL4R) compared with the IgMlo branch
The antigen receptor loci are the only loci in humans to undergo programmed somatic gene modification. Although aberrant V(D)J integration and class switch recombination can both give rise to chromosomal translocations, a role for somatic hypermutation in such genomic rearrangements has been suggested but is less clearly established. To characterize the types of by-products of somatic hypermutatio
A protein interacting with an A-T-rich region that is a positive control element within the SP6 κ promoter was purified and identified as CArG-box binding factor-A. The purified protein was shown to interact specifically with the coding strand of single-stranded DNA and, with lower affinity, with double-stranded DNA. A mutation that inhibited binding of the protein to the A-T-rich region also abor
