Purpose: The development of blood biomarkers that reflect Alzheimer’s disease (AD) pathophysiology (phosphorylated tau and amyloid-β) has offered potential as scalable tests for dementia differential diagnosis and early detection. In 2019, the Geneva AD Biomarker Roadmap Initiative included blood biomarkers in the systematic validation of AD biomarkers. Methods: A panel of experts convened in Nove

Different ZnO nanostructures can be grown using low-cost chemical bath deposition. Although this technique is cost-efficient and flexible, the final structures are usually randomly oriented and hardly controllable in terms of homogeneity and surface density. In this work, we use colloidal lithography to pattern (100) silicon substrates to fully control the nanorods' morphology and density. Moreove

In this study, the effect of axial heat conduction on thermal performance in a zigzag channel printed circuit heat exchanger (PCHE) with supercritical liquefied natural gas as the working fluid is studied by a numerical method under different conditions. The influence factors include Reynolds number, operating pressure, inlet temperatures of the cold side, and wall thermal conductivity. The result

Purpose: This study was designed to evaluate the performance of typically developing Swedish-speaking children on DYMTA (Dynamisk Motorisk Talbedömning), a Swedish dynamic motor speech assessment. Method: Participants were 94 children, 45 boys/49 girls (9/8 multilingual), with typical oral motor, speech, and language skills, between 37 and 106 months divided into five age-groups. They performed tw

Biomimicry at the hardware level is expected to overcome at least some of the challenges, including high power consumption, large footprint, two-dimensionality, and limited functionality, which arise as the field of artificial intelligence matures. One of the main attributes that allow biological systems to thrive is the successful interpretation of and response to environmental signals. Taking in

Purpose: The primary objective was to evaluate prescribing trends for topical ocular hypotensive treatment in the Nordic region during the last decade and, by population projections, estimate the glaucoma burden in 2040. A secondary objective was to analyse national variations in prescription patterns across the Nordic region. Methods: A retrospective analysis of national pharmacy data between 200

Objectives: To analyze the clinical outcome of percutaneous coronary intervention (PCI) using the Xience drug eluting stent (DES) versus other modern DES. Methods: This retrospective study based on the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) analyzed the outcome of PCI using Xience versus other commonly used modern DES, 2007 to 2017. The primary outcome measure was a combinat

Background: Allergen avoidance is important in allergic asthma management. Nocturnal treatment with Temperature-controlled Laminar Airflow (TLA) has been shown to provide a significant reduction in the exposure to allergens in the breathing zone, leading to a long-term reduction in airway inflammation and improvement in Quality of life (QoL). Allergic asthma patients symptomatic on Global Initiati

Closely related species that have previously inhabited geographically separated ranges are hybridizing at an increasing rate due to human disruptions. These human-mediated hybrid zones can be used to study reproductive isolation between species at secondary contact, including examining locus-specific rates of introgression. Introgression is expected to be heterogenous across the genome, reflecting

We present a localization algorithm for low-power long-range Internet-of-things (IoT) networks, which exploits angle of arrival (AoA) and range information from non-coherent received signal strength (RSS) measurements. In this work, each anchor node is equipped with array antennas of known geometry and radiation patterns. The position of the target node and the path-loss exponent to each anchor ar

Introduction: The treatment strategies for a 42-year-old female index patient with moderate Graves’ disease (GD) vary according to several international surveys. The important question whether surveys of treatment preferences in theoretical patient cases also match how real patients are treated has not yet been addressed. Materials and Methods: From a Swedish cohort of 1186 GD patients (TT-12 coho

High proportion of patients with multiple myeloma suffer from comorbidities which may alter clinical management. Therefore, our aims were to evaluate the prevalence of comorbidities and their impact on survival. We included patients diagnosed with multiple myeloma 1990-2013 in Sweden and all diagnoses from each patient from 1985. A total of 13 656 patients with multiple myeloma were included in th

In 2020, almost all research labs in industry, academia, and the government were shut down for long periods of time by political leaders to control the spread of the coronavirus. We consider the “micro” and “macro” implications of ongoing coronavirus disruptions in scientific research and the dissemination and commercialization of that research. We have identified three key unanswered research que

Background and objectives: COVID-19 convalescent plasma is an experimental treatment against SARS-CoV-2. The aim of this study is to assess the impact of different pathogen reduction methods on the levels and virus neutralizing activity of the specific antibodies against SARS-CoV2 in convalescent plasma. Materials and methods: A total of 140 plasma doses collected by plasmapheresis from COVID-19 c

This study aimed to validate the summation methods suggested by ISO 9920. Twenty seven items from an ambulance personnel clothing system were selected for testing. The basic insulation of each garment item (Iclu) was calculated based on the thermal manikin tests. More than 100 realistic clothing combinations were compiled and basic insulation (Icl) of these ensembles was calculated according to IS

BackgroundAssessment and treatment of the acutely ill patient have improved by introducing systematic assessment and accelerated protocols for specific patient groups. Triage systems are widely used, but few studies have investigated the ability of the triage systems in predicting outcome in the unselected acute population. The aim of this study was to quantify the association between the main com

Predation is a well-studied driver of ecological selection on prey traits, which frequently drives divergence in anti-predator performance across environments that vary in predation risk. However, predation also alters prey mortality regimes, where low predation risk often results in higher prey densities and consequently higher intensities of intraspecific resource competition. In addition, preda

Phthalates are widely used in consumer products. Exposure to phthalates can lead to adverse health effects in humans, with early-life exposure being of particular concern. Phthalate exposure occurs mainly through ingestion, inhalation, and dermal absorption. However, our understanding of the relative importance of different exposure routes is incomplete. This study estimated the intake of five pht