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Previous studies have demonstrated an effect of corticotropin-releasing factor 2 receptor (CRF2R) agonists in the maintenance of skeletal muscle mass. The aim of this study was to evaluate the effects of a CRF2R agonist in preserving skeletal muscle in a mouse cachexia model. Implantation of a fast-growing tumor to mice (Lewis lung carcinoma) resulted in a clear cachectic state characterized by a

Implantation of the Yoshida AH-130 ascites hepatoma to rats resulted in a decrease in muscle weight 7 days after the inoculation of the tumor. These changes were associated with increases in the mRNA content for both peroxisome proliferator-activated receptor (PPAR) gamma and PPAR delta in skeletal muscle. The increase in gene expression for these transcription factors was related to increases in

Proteolysis in skeletal muscle is mainly carried out by the activity of the ubiquitin-dependent proteolytic system. For the study of protein degradation through the ubiquitin-proteasome pathway, we used a model of hyperthermia in murine myotubes. In C2C12 cells, hyperthermia (41°C) induced a significant increase in both the rate of protein synthesis (18%) and degradation (51%). Interestingly, the

In our homes we enjoy daylight reaching the rooms through the windows, and artificial lighting when there is not enough daylight available. Electrical lighting has been used in Western homes since the late 1910s. We have experienced the technical development from warm incandescent light bulbs to energy-efficient light emitting diods (LED). In Sweden we lack daylight in winter and have a lot of day

The European Union plays a globally influential role in environmental legislation, with policies and regulation rooted in particular norms. Through a narrative on regulatory capitalism, ecological modernization, and diffusion, we trace how the promotion of renewable energy in transport through subsidies, mandatory targets, and prescriptive criteria for liquid biofuels mobilize social forces for itThe European Union plays a globally influential role in environmental legislation, with policies and regulation rooted in particular norms. Through a narrative on regulatory capitalism, ecological modernization, and diffusion, we trace how the promotion of renewable energy in transport through subsidies, mandatory targets, and prescriptive criteria for liquid biofuels mobilize social forces for it

Despite promises that they can contribute toward more environmentally beneficial transportation there are many sustainability concerns about liquid transport biofuels. In response to pressure from civil society, the European Union (EU) has introduced sustainability criteria for biofuels. A hybrid regulatory system involving state and non-state actors stipulates that retailers and producers must co

The book “Energy and Transport in Green Transitions – Perspectives on Ecomodernity” deals with the societally and scientifically crucial topic of energy and climate change mitigation. The book starts by setting high ambitions as the authors attempt “to go beyond both the extremism of the anti-capitalist critique and the radical enthusiasm of techno-economic positivism” in their exploration to find

The report examines the integrated Nordic power market and its linkages to renewable energy technology (RET) deployment for power production. It has two purposes. First, it aims to improve the understanding of the expansion of the Nordic power market and integration and deployment of RET. Secondly, it takes lessons from the Nordic experience that could inform the development, deployment and integr

Hemoglobin (Hb) is well protected inside the red blood cells (RBCs). Upon hemolysis and when free in circulation, Hb can be involved in a range of radical generating reactions and may thereby attack several different biomolecules. In this study, we have examined the potential damaging effects of cell-free Hb on plasmid DNA (pDNA). Hb induced cleavage of supercoiled pDNA (sc pDNA) which was proport

During the late Eocene there was an enigmatic enhancement in the flux of extraterrestrial material to Earth. Evidence comes from sedimentary 3He records indicating an increased flux of interplanetary dust during ca. 2 Myr, as well as two very large impact structures, Popigai (100 km diameter) and Chesapeake Bay (40–85 km), that formed within 10–20 kyr at the peak of the 3He delivery. The Massignan

Membrane filtration is a possible alternative for the increase of the natural organic matter (NOM) content in the raw water sources in boreal areas. In a pilot study, a new hollow fiber nanofilter (HFNF) has been tested. Water from four raw water sources were treated in membrane pilot plants, and three full-scale conventional plants were sampled. Three established fluorescence indices, humificatio

We explore the link between informativeness of signals, stochastic dominance and equilibrium bids in a multi-unit auction with risk averse bidders. We show that for a particular class of signal distributions, informativeness is related to conditional first-order stochastic dominance, so that a higher degree of informativeness in the signal-fundamental distribution induces higher bids and therefore

Background Individuals without occupational exposure are exposed to mercury (Hg) from diet and dental amalgam. The kidney is a critical organ, but there is limited information regarding the relationship between Hg in kidney (K-Hg), urine (U-Hg), blood (B-Hg), and plasma (P-Hg). Objectives The aim was to determine the relationship between K-Hg, U-Hg, B-Hg, and P-Hg among environmentally exposed ind

Whilst 50% of child protection workers across much of Europe and the affluent ‘West’ leave after two years, many stay and develop substantial professional careers. This paper discusses research in Italy, Sweden and England examining what factors explain ‘remaining’ for more than three years in this stressful job. Underpinned by a hermeneutic epistemology, qualitative interviews were undertaken and