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This thesis, which is based on four original papers, covers different aspects of antibody development. The overall goal of my work has been to obtain an increased understanding of antibody repertoires as they develop in vivo and in vitro. In Paper I-III antibody repertoires was evaluated and used to dissect virus-induced antibody responses and characterize such antibodies. Furthermore, tools for m
We present a method for creating and validating a nonlinear controller by the composition of heterogeneous local control laws appropriate to different operating regions. Like fuzzy logic control, these methods apply even in the presence of incomplete knowledge of the structure of the system, the boundaries of the operating regions, or even the control action to take. Unlike fuzzy logic control, th
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Solar energy is a renewable energy source which in the long term is important to develop because the usage does not effect the environment in a negative way. Increased energy exchange and cheaper production costs for solar collectors and solar cells are main factors in making the solar energy commercially successful in the future. Small scale solar collector systems are most common today because t
OBJECTIVES: An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (IHD) mortality. METHODS: Multivariate 10-year survival analysis in a population
Abstract in German Grundlegende Daten zur Beurteilung der thermischen Beanspruchung während der Arbeit in Schutzkleidung wurden im europäischen Verbundprojekt THERMPROTECT (EU Contract-No. G6RD-CT-2002-00846) mit Untersuchungen des durch die Kleidung erhöhten Energieumsatzes und des Transports von Wärme und Feuchte unter Kältebelastung sowie bei Einwirkung von Wärmestrahlung erhoben. Der Eingang d
The frame story in Parsifal is situated in a dystopian Europe, devastated, war-weary and in a state of shock and decay. Main protagonists are a retired general, Piscator (cf. Fisher King) and a middle aged unemployed female journalist, Perle Vaus (cf.Perlesvaus/Perceval/Parsifal). With her questions Perle is trying to help the general to write his memoirs in a truthful way.
The game w
