Background: Gallbladder cancer (GBC) is an aggressive, uncommon malignancy, with variation in operative approaches adopted across centres and few large-scale studies to guide practice. We aimed to identify the extent of heterogeneity in GBC internationally to better inform the need for future multicentre studies. Methods: A 34-question online survey was disseminated to members of the European-Afri

PurposeThe purpose of this commentary paper is to analyze the burst of joy experienced by global football fans when England lost the final match during the Euro 2020 against Italy.Design/methodology/approachThe author worked with netnography (Internet ethnography), gathering material from the internet.FindingsThe author would consider the emotional explosion as a creative expression that was possi

This abstract describes the decomposition of a matrix representing a scattering dyadic into characteristic modes. Scattering dyadic, as compared to conventionally used impedance matrices, are independent of numerical method used to compute them and the same characteristic mode formulation can be used for decomposition of composite and inhomogeneous materials. The utilization of scattering dyadic m

The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis of CNVs in 15,342 BRCA1 and 10,740 BRCA2 pathogenic variant carriers. We used these results to prioritise a candidate breast cancer risk-modifier gene for laboratory analysis and biolog

Any reasonable model of sedimentation contains the nonlinear hindered-settling flux function. If one assumes ideal conditions and no compression, then there exist several theoretically possible ways of identifying a large part of the flux function from only one experiment by means of formulas derived from the theory of partial differential equations. Such identification methods, including new resu

Many people and organizations across the globe work towards a sustainable future. Artificial intelligence (AI) can be a powerful tool in their efforts.AI technologies, which aim to imitate the natural intelligence of humans and animals, have made enormous progress in the past decade. AI has brought us a whole range of futuristic tools — from self-driving cars to virtual assistants, smart home appl

Tjänstesamhället och den tjänsteinriktade ekonomin som växt fram under efterkrigstiden (Yarmolinsky 1968), innebär nya förhållningssätt, krav och villkor för traditionella yrkesgrupper. En händelse som pandemin ritade ytterligare om förhållningssätt och normer kring arbetet. Varje tid har sina föreställningar om arbete, vad som är en lämplig anställd eller en bra chef. Varför sker sådana normförsk

Background: There are indications that early-life exposure to perfluoroalkyl substances (PFAS) can impact neurodevelopment, but results are inconclusive. The objective was to investigate if high early-life exposure to primarily perfluorohexanesulfonic acid (PFHxS) and perfluorooctanesulfonic acid (PFOS) increases the risk of developmental language disorder in children up to seven years of age.Meth

The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation. From this, we looked for inflammatory markers that coincided with the increased amount of O-linked Tn antigen (GalNAcα1-Ser/Thr) glycan on SF lubricin. Inflammatory markers in plasma and SF in OA patients and controls were measure

Land biosphere processes are of central importance to the climate system. Specifically, ecosystems interact with the atmosphere through a variety of feedback loops that modulate energy, water, and CO2 fluxes between the land surface and the atmosphere across a wide range of temporal and spatial scales. Human land use and land cover modification add a further level of complexity to land-atmosphere

Microservice applications consist of a set of smaller services interacting in a graph structure to deliver the full application. Jobs will traverse this graph in different paths, both depending on the type of job, but also on the current load of different service replicas. Different paths will incur different scenario-specific costs, dependent on, e.g., deployment and the underlying cloud system.