Fibromodulin-deficient Mice Display Impaired Collagen Fibrillogenesis in Predentin as well as Altered Dentin Mineralization and Enamel Formation.
To determine the functions of fibromodulin (Fmod), a small leucine-rich keratan sulfate proteoglycan in tooth formation, we investigated the distribution of Fmod in dental tissues by immunohistochemistry and characterized the dental phenotype of 1-day-old Fmod-deficient mice using light and transmission electron microscopy. Immunohistochemistry was also used to compare the relative protein express