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Infiltration of red blood cells into atheromatous plaques and oxidation of hemoglobin (Hb) and lipoproteins are implicated in the pathogenesis of atherosclerosis. α1‐microglobulin (A1M) is a radical‐scavenging and heme‐binding protein. In this work, we examined the origin and role of A1M in human atherosclerotic lesions. Using immunohistochemistry, we observed a significant A1M immunoreactivity in

Cell-free mitochondrial DNA (cf-mtDNA) is a marker of inflammatory disease and a predictor of mortality, but little is known about cf-mtDNA in relation to psychobiology. A systematic review of the literature reveals that blood cf-mtDNA varies in response to common real-world stressors including psychopathology, acute psychological stress, and exercise. Moreover, cf-mtDNA is inducible within minute

The COVID-19 pandemic has had a vast influence on Swedish society. Related recommen-dations and political decisions have greatly affected schools. This study aimed to describe school nurses’ experience working in Sweden during the pandemic in 2020. The study used a qualitative method with an inductive approach. Interviews with 17 school nurses in five focus groups and one individual interview were

High-resolution precision spectroscopy provides a multitude of robust techniques for probing exoplanetary atmospheres. We present multiple VLT/ESPRESSO transit observations of the hot-Jupiter exoplanet WASP-19b with previously published but disputed atmospheric features from lowresolution studies. Through spectral synthesis and modelling of the Rossiter-McLaughlin (RM) effect we calculate stellar,

Despite interventions aiming to improve outcomes among older adults experiencing financial challenges, the challenges and strategies employed to handle them are poorly understood. This study examined the experiences of financial challenges among low-income adults aged ≥65 years. Eleven semi-structured interviews were analyzed using thematic analyses. An overarching theme was “I guess it balances”,

This chapter deals with communication management as a specific form of management communication responsible for authoring, enacting, and controlling anorganization’s communication to create value. The chapter covers central ideas in thecommunication management literature, the practices, forms and contexts of communication management, and how the communication management literature has approached t

Information systems are key enablers for the integration and reliable management of the product development process. Fast, robust, and cost-efficient product adaptation is especially important in one-of-a-kind production. This paper presents an implementation of information supported tools of the product development (PD) design process for large power transformers. One-of-a-kind production is spec

Changes in mitochondrial DNA copy number (mtDNA-CN) and telomere length have, separately, been proposed as risk factors for various cancer types. However, those results are conflicting. Here, mtDNA-CN and relative telomere length were measured in 3225 middle-aged women included in a large population-based prospective cohort. The baseline mtDNA-CN in patients with prevalent breast cancer was signif

Mangroves are among the most productive ecosystems in existence, with many ecological benefits. Therefore, generating accurate thematic maps from mangrove ecosystems is crucial for protecting, conserving, and reforestation planning for these valuable natural resources. In this paper, Sentinel-1 and Sentinel-2 satellite images were used in synergy to produce a detailed mangrove ecosystem map of the

Starting four decades ago, studies have examined the ecology and evolutionary dynamics of populations and species using short mitochondrial DNA fragments and stable isotopes. Through technological and analytical advances, the methods and biomolecules at our disposal have increased significantly to now include lipids, whole genomes, proteomes, and even epigenomes. At an unprecedented resolution, th

BACKGROUND: Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed due to measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk.METHODS: Untargeted metabolomics was used to identify metabolites correlated with self-reported habitua

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease and renal replacement therapy worldwide. A pathophysiological hallmark of DKD is glomeru- lar basal membrane (GBM) thickening, whereas this feature is absent in minimal change disease (MCD). According to fundamental transport physiological principles, a thicker GBM will impede the diffusion of middle-molecules such as cyst

Personer som deltar i en väpnad konflikt och som i samband med konflikten poserar på bild eller film intill stympade eller kränkta människokroppar kan lagföras för krigsförbrytelse i Sverige. Enligt Högsta domstolens avgörande 2021-05-05, mål nr B 5595-19. utgör en sådan handling en allvarlig kränkning av de dödas personliga värdighet som är straffbelagt med fängelse. Artikeln analyserar fallet.

In rendering research and development, it is important to have a formalizedway of visualizing and communicating how and where errors occur whenrendering with a given algorithm. Such evaluation is often done by comparingthe test image to a ground-truth reference image. We present a tool for doingthis for both low and high dynamic range images. Our tool is based on aperception-motivated error metric

The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC), which consists of dead keratin-filled cells embedded in a lipid matrix. The skin is daily exposed to an environment with changing conditions in terms of hydration and different chemicals. Here we investigate how a molecule that has reasonable solubility in both hydrophobic and hydrophilic environments

In human cells, P5B-ATPases execute the active export of physiologically important polyamines such as spermine from lysosomes to the cytosol, a function linked to a palette of disorders. Yet, the overall shape of P5B-ATPases and the mechanisms of polyamine recognition, uptake and transport remain elusive. Here we describe a series of cryo-electron microscopy structures of a yeast homolog of human