Objective: Clinical observations over time of adults with growth hormone (GH) deficiency (GHD) have indicated a shift in patient characteristics at diagnosis. The objective of this study was to compare baseline characteristics of patients diagnosed with adult-onset GHD naive to GH replacement during t hree study periods (1994-1999 (P1), 2000-2004 (P2), and 2005-2012 (P3)) using the KIMS (Pfizer's

Electric road systems (ERS) are technologies that allow to charge electric vehicles (EVs) while they are driving. A large scale implementation of ERS would allow to significantly reduce the installed battery capacity on board the vehicles, which consequently reduces their weight and cost. Due to geographical, practical and economic constraints the ERS is not expected to cover the full extension of

Mi Lennhag reviews Vory: den ryska supermaffian (The Vory: Russia’s Super Mafia) by Mark Galeotti (translated by Manne Svensson). The book examines organized crime in the Soviet Union and in post-Soviet Russia. Historical, political and cultural contexts help explaining the Russian mafia and the phenomenon vory. Galeotti pictures a Russian society where politics and organized crime remain closely

The influence of grain boundaries on the mechanical properties of poly-crystalline metals is well known. Here we investigate the influence from a centrally placed grain boundary in nano-sized beams of Cu subjected to tensile loading. The crystallographic orientations in the grains are [100], [110] and [111]. The investigation is performed by means of molecular dynamic simulations employing the molThe influence of grain boundaries on the mechanical properties of poly-crystalline metals is well known. Here we investigate the influence from a centrally placed grain boundary in nano-sized beams of Cu subjected to tensile loading. The crystallographic orientations in the grains are [100], [110] and [111]. The investigation is performed by means of molecular dynamic simulations employing the mol

The amount of short wavelength (ultraviolet (UV), violet and blue) light that reaches the retina depends on the transmittance properties of the ocular media, especially the lens, and varies greatly across species in all vertebrate groups studied previously. We measured the lens transmittance in 32 anuran amphibians with different habits, geographical distributions and phylogenetic positions and us

Introduction. When using bibliometrics for research evaluation, the classification of research fields is an issue of great importance. The purpose of this paper is to outline a brief theoretical framework for analysing the role of classification in research evaluation practices.Theory. Taking departure in the concept of ‘boundary objects’ we develop a theoretical framework for analyses of how scie

A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with pot

Studies of the fragmentation of jets into charged particles in heavy-ion collisions can provide information about the mechanism of jet quenching by the hot and dense QCD matter created in such collisions, the quark-gluon plasma. This paper presents a measurement of the angular distribution of charged particles around the jet axis in sNN=5.02 TeV Pb+Pb and pp collisions, using the ATLAS detector at

The majority of studies on mental health in deaf and hard-of-hearing (DHH) children report a higher level of mental health problems. Inconsistencies in reports of prevalence of mental health problems have been found to be related to a number of factors such as language skills, cognitive ability, heterogeneous samples as well as validity problems caused by using written measures designed for typica

Context: Chronic breathlessness is a clinical syndrome that results in significant distress and disability. Morphine can reduce chronic breathlessness when the contributing etiologies are optimally treated. Objectives: Does oxycodone reduce chronic breathlessness compared with placebo? Methods: A multisite, randomized, placebo-controlled, double-blind, parallel-arm, fixed-dose trial of oral contro

Valosin-containing protein (VCP, also called p97) is an essential and highly conserved adenosine triphosphate-dependent chaperone implicated in a wide range of cellular processes in eukaryotes, and mild VCP mutations can cause severe neurodegenerative disease. Here we show that mammalian VCP is trimethylated on Lys315 in a variety of cell lines and tissues, and that the previously uncharacterized

This doctoral dissertation comprises three independent essays on information transmission and crisis spillover in the financial markets. The research questions are examined in the context of the foreign exchange market, the stock market and the global banking system.The first paper, The Response of Exchange Rates to Central Bank Communication: A Textual Analysis Approach, investigates how European

Measurements of KS0 and Λ production in tt¯ final states have been performed. They are based on a data sample with integrated luminosity of 4.6 fb - 1 from proton–proton collisions at a centre-of-mass energy of 7 TeV, collected in 2011 with the ATLAS detector at the Large Hadron Collider. Neutral strange particles are separated into three classes, depending on whether they are contained in a jet,

Purpose: To address the systematic bias in whole-brain dual flip angle (DFA) T1-mapping at7T by optimizing the flip angle pair and carefully selecting RF pulse shape and duration.Theory and Methods: Spoiled gradient echoes can be used to estimate whole-brain maps ofT1. This can be accomplished by using only two acquisitions with different flip angles, i.e., aDFA-based approach. Although DFA-based Purpose: To address the systematic bias in whole-brain dual flip angle (DFA) T1-mapping at 7T by optimizing the flip angle pair and carefully selecting RF pulse shape and duration. Theory and Methods: Spoiled gradient echoes can be used to estimate whole-brain maps of T1. This can be accomplished by using only two acquisitions with different flip angles, i.e., a DFA-based approach. Although DFA-ba

BACKGROUND: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. METHODS: In thi

Introduction: The objective was to create a clinically useful prediction model for vaginal birth in trial of labor after one cesarean section, appropriate for a third trimester consultation. Material and methods: Women with one cesarean section and at least one following delivery (N = 38 686) in the Swedish Medical Birth Register, 1998-2013, were studied. The women were randomly divided into one d