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Motivationk–Top Scoring Pairs (kTSP) algorithms utilize in-sample gene expression feature pair rules for class prediction, and have demonstrated excellent performance and robustness. The available packages and tools primarily focus on binary prediction (i.e. two classes). However, many real-world classification problems e.g., tumor subtype prediction, are multiclass tasks.ResultsHere, we present m
Climate change and human activities influence the development of ecosystems, with human demand of ecosystem services altering both land use and land cover. Fossil pollen records provide time series of vegetation characteristics, and the aim of this study was to create spatially continuous reconstructions of land cover through the Holocene in southern Sweden. The Landscape Reconstruction Algorithm
The Swedish Municipality Act, issued in 1862, consolidated a plutocratic system in which ownership and income, and the resulting level of taxation, translated into political power. However, as a measure to hinder large landowners from holding a majority of the votes, the Act guaranteed voting rights for tenants. The aim of the article is to analyse how power relations played out after this challen
Background: There is a lack of studies of Huntington’s disease (HD) in immigrants. Objective: To study the association between country of birth and incident HD in first-generation immigrants versus Swedish-born individuals and in second-generation immigrants versus Swedish-born individuals with Swedish-born parents. Methods: Study populations included all adults aged 18 years and older in Sweden,
Background: Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and monitor early meniscus degeneration related to knee osteoarthritis. Objective: To investigate MR relaxation times as potential biomarkers for meniscus degeneration through comparison
Purpose: Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir on its quantitative accuracy. Procedures: Two study cohorts with Alzheimer’s dis
For infants and their families, sleep consolidation is important in maturing neural and circadian rhythms, and in family dynamics. The Possums Infant Sleep Program is a cued care approach to infant sleep, responding to infant cues in a flexible manner, dialing down the infant’s sympathetic nervous system. The current study evaluated the effect of the Possums program on infant sleep and breastfeedi
Chemical processing by plasma is utilized in many applications. Plasma-related studies, however, are challenging to carry out due to plasmas' transient and unpredictable behavior, excessive luminosity emission, 3D complexity and aggressive chemistry and physiochemical interactions that are easily affected by external probing. Laser-induced fluorescence is a robust technique for non-intrusive inves
We investigate robustness properties of the Generalized Proportional Allocation (GPA) policy that has been recently proposed for traffic signal control in urban networks. The GPA policy is fully decentralized, relies only on local information on the current congestion state, and requires no knowledge of the routing, the exogenous inflows, or the network structure. In previous work, we proved throu
The asymptotic behaviour of deterministic logit dynamics in heterogeneous routing games is analyzed. It is proved that in directed multigraphs with parallel routes, and in series composition of such multigraphs, the dynamics admits a globally asymptotically stable fixed point. Moreover, the unique fixed point of the dynamics approaches the set of Wardrop equilibria, as the noise vanishes. The resu
We study a robust control problem for dynamical flow networks. In the considered framework, traffic flows along the links of a transportation network —modeled as a capacited multigraph— and queues up at the nodes, whereby control policies determine which incoming queues are to be allocated service simultaneously, within some predetermined scheduling constraints. We first prov
We study the asymptotic behavior of deterministic, continuous-time imitation dynamics for population games over networks. The basic assumption of this learning mechanism --- encompassing the replicator dynamics --- is that players belonging to a single population exchange information through pairwise interactions, whereby they get aware of the actions played by the other players and the correspond
The FBI recently arrested an Iranian academic for failing to register as a foreign agent in accordance with the Foreign Agents Registration Act. Kaveh Afrasiabi was arrested in Massachusetts and is believed to have received more than $250,000 from the Iranian regime to disseminate its propaganda in the guise of objective analysis. Iranian agent-scholars are easy to recognize: they always oppose th
The Supreme Leader of the Islamic Republic of Iran, Ali Khamenei, is 81 years old and reportedly in declining health. The question of the succession will be decided by the regime’s Assembly of Experts, who will choose the new Supreme Leader following Khamenei’s death. Six individuals have emerged as possible successors.
Over the last several decades, the light-harvesting protein complexes of purple bacteria have been among the most popular model systems for energy transport in excitonic systems in the weak and intermediate intermolecular coupling regime. Despite this extensive body of scientific work, significant questions regarding the excitonic states and the photo-induced dynamics remain. Here, we address the
Fluorescence decay measurements of the rate of non-radiative direct energy transfer have been employed to characterize the core and the core-corona interface of polyisoprene-poly(methyl methacrylate) (PI-PMMA) diblock copolymer micelles in acetonitrile. These micelles consist of a core of the insoluble PI blocks and a corona of the soluble PMMA blocks. The block copolymers are labeled, at the bloc
