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Host Defense Peptides LL-37 and Lactoferrin Trigger ET Release from Blood-Derived Circulating Monocytes

Neutrophils are commonly regarded as the first line of immune response during infection or in tissue injury-induced inflammation. The rapid influx of these cells results in the release of host defense proteins (HDPs) or formation of neutrophil extracellular traps (NETs). As a second wave during inflammation or infection, circulating monocytes arrive at the site. Earlier studies showed that HDPs LL

Peri-implantitis : Summary and consensus statements of group 3. The 6th EAO Consensus Conference 2021

Objective: To evaluate the influence of implant and prosthetic components on peri-implant tissue health. A further aim was to evaluate peri-implant soft-tissue changes following surgical peri-implantitis treatment. Materials and methods: Group discussions based on two systematic reviews (SR) and one critical review (CR) addressed (i) the influence of implant material and surface characteristics on

Ögonlocket krossade drömmen om Amerika

PURPOSE: To investigate Swedish immigrants to the United States debarred for medical reasons, with particular focus on trachoma. METHOD: Annual official reports of debarred immigrants have been compiled to compare reasons for debarment among Scandinavian immigrants vs. immigrants from all countries. Individual cases of trachoma among Swedish immigrants have been searched for in contemporary newspa

Acute effect of traditional and adaptive metronomes on gait variability in older individuals with a history of falls

Background: Metronome cueing has been shown to reduce gait variability and thereby potentially reduce falls risk in individuals with Parkinson’s disease. It is unclear however, if metronome cueing has a similar effect in healthy older adults with a history of falls. Aim: To investigate whether a traditional and/or an adaptive metronome, based on an individual’s gait pattern, were effective in redu

Structural analysis of botulinum neurotoxins type B and E by Cryo-EM

Botulinum neurotoxins (BoNTs) are the causative agents of a potentially lethal paralytic disease targeting cholinergic nerve terminals. Multiple BoNT serotypes exist, with types A, B and E being the main cause of human botulism. Their extreme toxicity has been exploited for cosmetic and therapeutic uses to treat a wide range of neuromuscular disorders. Although naturally occurring BoNT types share

Online Sparse Reconstruction for Scanning Radar Using Beam-Updating q-SPICE

The generalized sparse iterative covariance-based estimation ( $q$ -SPICE) algorithm was recently introduced for scanning radar applications, resulting in substantial improvements in the angular resolution and quality of the processed images. Regrettably, the computational complexity and storage cost are high and quickly increase with growing data size, limiting the applicability of the estimator.

ACN-Sim : An Open-Source Simulator for Data-Driven Electric Vehicle Charging Research

ACN-Sim is a data-driven, open-source simulation environment designed to accelerate research in the field of smart electric vehicle (EV) charging. It fills the need in this community for a widely available, realistic simulation environment in which researchers can evaluate algorithms and test assumptions. ACN-Sim provides a modular, extensible architecture, which models the complexity of real char

Avoidance, rationalization, and denial : Defensive self-protection in the face of climate change negatively predicts pro-environmental behavior

Despite urgent need for climate action, denial of climate change and resulting absence of appropriate pro-environmental behavior are widespread. Interpretive (recognition of climate change as a problem but re-interpretation of its severity) and implicatory denial of climate change (recognition of climate change as a problem but denial of psychological, political, and moral implications) can be int

Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD) : A Report of an International Research Collaboration Network

Longitudinal observational cohort studies are being conducted worldwide to understand cognition, biomarkers, and the health of the aging population better. Cross-cohort comparisons and networks of registries in Alzheimer's disease (AD) foster scientific exchange, generate insights, and contribute to the evolving clinical science in AD. A scientific working group was convened with invited investiga

Immune functions in melanoma patients during treatment with interferon [HuIFN-alpha (Le)] alone or in combination with cimetidine

While leukocyte interferon was found therapeutically ineffective in a series of 20 patients with metastatic malignant melanoma, subsequent combination treatment with interferon and cimetidine induced 5 complete and 1 partial tumour remissions. Prior to interferon therapy initiation, regressor patients demonstrated a significantly greater ability to mediate antibody-dependent cellular cytotoxicity

COVID-19 infection among bartenders and waiters before and after pub lockdown

OBJECTIVE: To assess how different bans on serving alcohol in Norwegian bars and restaurants were related to the detection of SARS-CoV-2 in bartenders and waiters and in persons in any occupation. METHODS: In 25 392 bartenders and waiters and 1 496 328 persons with other occupations (mean (SD) age 42.0 (12.9) years and 51.8% men), we examined the weekly rates of workers tested and detected with SA

Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle

Sleep is a state in which important restorative and anabolic processes occur. Understanding changes of these metabolic processes during the circadian rhythm in the brain is crucial to elucidate neurophysiological mechanisms important for sleep function. Investigation of amino acid modifications and dipeptides has recently emerged as a valuable approach in the metabolic profiling of the central ner

A randomized study of chemotherapy with procarbazine, vincristine, and lomustine with and without radiation therapy for astrocytoma grades 3 and/or 4

The authors undertook a controlled, prospective, randomized study of 171 patients with supratentorial astrocytoma grades 3 and/or 4 (classified according to Kernohan). All patients were given chemotherapy consisting of procarbazine, vincristine, and lomustine (CCNU) (PVC). Half of the patients received whole-brain irradiation (RT) to a dose of 5800 cGy in the tumor-bearing hemisphere and 5000 cGy

Phenotypic plasticity in floral scent in response to nutrient, but not water, availability in the perennial plant Arabis alpina

Floral scent is an important mediator of plant–pollinator interactions. Multiple recent studies report ample intraspecific scent variation among populations and individuals. Yet, few studies have eastimated effects of phenotypic plasticity on floral scent in response to differing environmental factors. In this study, we investigated the effects of nutrient and water availability on floral scent in

Parkinson’s disease in Sweden—resource use and costs by severity

Objectives: To estimate resource use and costs, including direct and indirect costs, in relation to levels of severity in individuals with Parkinson's disease (PD) in a Swedish setting. Materials and methods: Patients with idiopathic PD registered in the National Parkinson's Disease Patient Registry (PARKreg), with registrations of Hoehn and Yahr (H&Y) and “off time” in the Skåne Region, were