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This thesis aimed to search for etiological clues about cancer of unknown primary(CUP) by gathering novel information. The Swedish national registries were used and CUP cases were identified according to the seventh revision of the International Classification of Diseases. A consistent increase before the late 1990s and a dramatic decrease afterwards were observed for CUP incidence among Swedes,re

Chromosomal translocations play a crucial role in tumorigenesis, often resulting in the formation of chimeric genes or in gene deregulation through position effects. T-cell acute lymphoblastic leukemia (T-ALL) is associated with a large number of such rearrangements. We report the ectopic expression of the 3' portion of EST DA926692 in the bone marrow of a childhood T-ALL case showing a t(2;11)(q1

Enzymatic degradation of model cellulose films pre-treated with antimicrobial agent, 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride (TMPAC) was investigated. AFM topographical imaging was used to assess the surface morphology, roughness, and thickness of the dried and hydrated model cellulose film. The kinetics of the model cellulose film in the hydrated state, the adsorption of TMP

Background: Improving maternal and reproductive health still remains a major challenge in most low-income countries especially in sub-Saharan Africa. The growing inequality in access to maternal health interventions is an issue of great concern. In Ghana, inadequate attention has been given to the inequality gap that exists amongst women when accessing antenatal care during pregnancy and skilled a

Background: Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes. Results: In two cohorts of primary breast cancers, PKC alpha levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKC delta a

Dissolution rate measurements are important to understand the behaviour of drugs or drug formulations. Many methods for measuring dissolution rates are available and a good choice should be based on method limitations as well as drug characteristics. In the present study the rotating disc method was critically evaluated for dissolution rate measurements, using aspirin and benzoic acid as model sub

This study examines possible success factors when developing technical solutions for dyslexic students. Findings in the literature, in a web survey answered by students and in the experiences from the development process at the Medical Faculty Library, Lund University, were used to find out potential success factors and difficulties. The literature found describes what dyslexia is, the situation f

Primary open angle glaucoma (POAG) is a major blindness-causing disease, characterized by elevated intraocular pressure due to an insufficient outflow of aqueous humor. The trabecular meshwork (TM) lining the aqueous outflow pathway modulates the aqueous outflow facility. TM cell adhesion, cell-matrix interactions, and factors that influence Rho signaling in TM cells are thought to play a pivotal

Background: Prior studies have identified some risk factors for stress fracture in athletes and military recruits. Objective: To determine whether historical factors, physical measures, biochemical variables of skeletal metabolism, genetic factors, bone density (BMD) and bone size could predict risk of stress fracture over 4 years in physically fit cadets at the US Military Academy (USMA). Methods

We investigate theoretically charge transport in hybrid multiterminal junctions with superconducting leads kept at different voltages. It is found that multiple Andreev reflections involving several superconducting leads give rise to rich subharmonic gap structures in the current-voltage characteristics. The structures are evidenced numerically in junctions in the incoherent regime.

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turnin

This study explores factors associated with the individual's appraisal of anticipated environmental changes caused by energy production facilities. The study took place in a Swedish village where exploratory drilling, that could eventually lead to a uranium mine, was being conducted at the same time as a wind farm was approved. Results from the survey, which included the total population, were int

The intensity of a fire is an important factor determining the recovery of soil microorganisms after a forest fire, since it can alter the quality and quantity of carbon sources. Recovery of the microbial community was studied in a Mediterranean pine forest soil subjected to different temperatures to simulate the short-term effects of fire intensity on bacterial and fungal growth, estimated using

Background: Different molecular subtypes of breast cancer have been identified based on gene expression profiling. Treatment suggestions based on an approximation of these subtypes by immunohistochemical criteria have been published by the St Gallen international expert consensus panel. Ductal carcinoma in situ (DCIS) can be classified into the same molecular subtypes. Our aim was to study the rel

Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified fiv

Use of utilities, such as steam and cooling water, is very common at industrial sites. Utilities are often shared between several production areas, and a disturbance in the supply of a utility is therefore likely to affect a large part of the production site, and cause great loss of revenue. In order to minimize the loss of revenue due to disturbances in utilities, the optimal supply of utilities